This supplement contains the papers submitted at EUROTOX 88, the joint Congress of the European Society of Toxicology and the Federation of the European Societies of Toxicology. The theme was one of monitoring and examining the effects of toxic substances in the biological response at the subcellular level. Mechanisms of metal carcinogenicity are discussed as well as the biomonitoring of chemical exposure. Reports are provided on the role of individual differences in man and the effect of risk assessment. Papers appear dealing with the genetic control of drug metabolizing enzymes. The role of...
This supplement contains the papers submitted at EUROTOX 88, the joint Congress of the European Society of Toxicology and the Federation of the Europe...
Many chemotherapeutic agents introduced for use in humans are carcinogenic in laboratory animals (Conklin et al. 1965; Shimkin et al. 1966; Griswold et al. 1968; Harris 1976). However, initially their beneficial effect in disseminated cancer was of such short duration that the inevitable death of the patient from his primary disease precluded any clinical manifestation of the carcinogenic potential. During the last decade, chemotherapy has radically changed the outlook for many patients with cancer. Combinations of drugs, administered as the primary treatment, have resulted in high rates of...
Many chemotherapeutic agents introduced for use in humans are carcinogenic in laboratory animals (Conklin et al. 1965; Shimkin et al. 1966; Griswold e...
Trichloroethylene (TRI), administered orally at high doses for 18 months has been shown to increase the incidence of hepatocellular carcinoma in B6C3F 1 mice but not Osborne-Mendel rats (NCI, 1976). The interpretation of these studies has been confounded due to the presence of epoxide stabilizers in the TRI. However more recent studies have demonstrated that pure TRI also causes hepatocellular carcinoma in B6C3F mice (NTP, 1983) and Aldedey Park (Swiss) mice (Elcombe 1 and Pratt, unpublished data). Furthermore, no increase in the incidence of hepatocellular carcinoma was observed in Fisher...
Trichloroethylene (TRI), administered orally at high doses for 18 months has been shown to increase the incidence of hepatocellular carcinoma in B6C3F...
This volume of conference proceedings contains papers on the neurotoxicology of different noxious compounds, new aspects and methods in toxicopathology, cardiovascular toxicology, toxic effects on haemostasis, the liver and the kidney, and miscellaneous toxic effects.
This volume of conference proceedings contains papers on the neurotoxicology of different noxious compounds, new aspects and methods in toxicopatholog...
The first oral contraceptive became available in 1960 and since then these sub stances, which have been used by millions of women, have probably been the most widely studied group of drugs in medical history (Drill, 1966, 1977). Part of the evaluation oCoral contraceptives has involved their effect on the reproductive organs of women, with particular attention directed to evaluation of a possible carcinogenic effect of these steroids. To the extent that cancer of the reproductive organs is a common finding in women, the endogenous female sex hormones have been implicated in the occur rence of...
The first oral contraceptive became available in 1960 and since then these sub stances, which have been used by millions of women, have probably been ...
N-nitroso-compounds form an important class of carcinogenic chemicals which may be of environmental importance (Druckrey et al. , 1967; Magee et al. , 1976; IARC, 1978). The mechanism by which these carcinogens initiate neoplastic growth is not well understood but there is substantial evidence favoring the hypothesis that the simple dialkylnitrosamines and alkylnitrosamides act by means of their conversion to al- kylating agents. Alkylating species are generated from the nitrosamines by metabolic activation and from the nitrosamides by chemical decomposition at physiological pH. It is widely...
N-nitroso-compounds form an important class of carcinogenic chemicals which may be of environmental importance (Druckrey et al. , 1967; Magee et al. ,...
For more than five decades Bertram Kostant has been one of the major architects of modern Lie theory. Virtually all his papers are pioneering with deep consequences, many giving rise to whole new fields of activities. His interests span a tremendous range of Lie theory, from differential geometry to representation theory, abstract algebra, and mathematical physics. It is striking to note that Lie theory (and symmetry in general) now occupies an ever increasing larger role in mathematics than it did in the fifties. Now in the sixth decade of his career, he continues to produce results of...
For more than five decades Bertram Kostant has been one of the major architects of modern Lie theory. Virtually all his papers are pioneering with ...
