The Target Organ and the Toxic Process: Proceedings of the European Society of Toxicology Meeting Held in Strasbourg, September 17-19, 1987

ISBN-13: 9783540185123 / Angielski / Miękka / 1988 / 462 str.

Philip L. Chambers; Claire M. Chambers; Guy Dirheimer

Spis treści

Phototoxicity, Photoallergy, Photomutagenicity and Photocarcinogenicity.- In Vitro and In Vivo Research on Phototoxic Xenobiotics: Structure-Reactivity Relationships.- Photoallergy, Mechanisms and Models.- Human Drug Photosensitivity: Predictive Studies in Guinea Pigs.- Photomutagenicity Induced by Psoralens: Mechanism of Repair and Photomutagenicity.- Photomutagenicity Induced by Psoralens: Modulation of the Photomutagenic Response in Eukaryotes.- Chemical Modifiers of Photocarcinogenesis.- Photogenotoxicity of Bergamot Oil in Salmonella Typhimurium TA102 and in V79 Chinese Hamster Cells: Efficiency Assessment of Filter Protective Effect.- DNA Damage Caused by Laser Light Activated Hematoporphyrin Derivatives in Isolated Nuclei of Human Melanoma Cells.- Systemic Photobiological Effects from Xenobiotics.- Photomutagenic Effect Induced by 4,4?,6 Trimethylangelicin in Salmonella typhimurium TA102 and Saccharomyces cerivisiae D7.- Adverse Effects on Thyroid Gland.- Mechanistic Studies on the Thyroid Toxicity Induced by Certain Drugs.- Comparison of the Effects of SK&F 93479 and Phenobarbitone Treatment on Thyroid Toxicity and Hepatic Thyroid Hormone Metabolising Enzymes in the Rat.- Thyroid Hyperactivity Caused by Hypolipodaemic Compounds and Polychlorinated Biphenyls: The Effect of Coadministration on the Liver and Thyroid.- The Effect of Sodium Bromide on Thyroid Function.- Hyperplastic and Neoplastic Responses of the Thyroid Gland in Toxicological Studies.- Chronic Zinc Ethylenebisdithiocarbamate Toxicity in Calves: Effects on the Thyroid and Clinicopathological Findings.- Lymphocytic Thyroiditis in Beagle Dogs.- Nephrotoxicity.- Nephrotoxicity of Antitumoral Agents.- Effect of Cadmium Ions on Na/K-ATPase Activity in a Defined Segment of the Rabbit Proximal Tubule.- In Vivo and In Vitro Assessment of Vancomycin-Induced Nephrotoxicity.- Renal Papillary Necrosis and Upper Urothelial Carcinoma.- Age-Dependent Differences in Nephrotoxicity of Xenobiotics.- Chronobiological Approach to Aminoglycosides.- Effects of Puromycin Aminonucleoside on Ten Urinary Enzymes in Rats.- Monoclonal Antibodies to Brush Border Antigens for the Early Diagnosis of Nephrotoxicity.- Effects of Cisplatin and Carboplatin on Cell Cultures of Renal and Non-renal Origin.- Reduction of Cisplatin Nephrotoxicity by Selenium: Does Metallothionein Play a Role?.- The Relationships Between Plasma Cyclosporin Levels and Renal Tubulotoxicity Assessed by Enzymuria After Liver Transplantation.- Renal Function in Lithium Treatment.- In Vitro Study and Conformational Analysis of 1-N-Aminohydroxybutyryl Derivatives of Aminoglycosides in Correlation with Their Inhibitory Potency Towards Lysosomal Phospholipases.- Proximal Tubule Brush Border Angiotensin Converting Enzyme Behaviour and Nephrotoxicity Due to 1,2-Dichloropropane.- Effects of Subsequent Peroral or Intravenous (“Refill”) Cholegraphy on Kidney Function in Dogs.- Dichlorovinylcysteine-Induced Nephrotoxicity: Role of Peroxidative Injury.- In Vivo Studies on the Relationship Between Hepatic Metabolism and Toxicity of Ochratoxin A.- Peroxisome Proliferation and Hepatotoxicity.- Hepatic Peroxisome Proliferation: An Overview.- Structure-Activity Relationships for Hepatic Peroxisome Proliferation.- Influence of Drugs on Liver Mitochondria and Peroxisomes.- Effects of Adipates, Phthalates and Fibrates on Liver Enzymes and Peroxisomes in a Variety of Mammalian Species.- Mechanisms of Tumour Induction by Peroxisome Proliferators.- Concomitant Induction of Cytosolic Epoxide Hydrolase and Peroxisomal ?-Oxidation by Hypolipidemic Compounds in the Rat and Guinea Pig Liver.- A Dicarboxylic Acid Derivative of the Hypolipidemic Peroxisome Proliferator, Tiadenol, Triggers Induction of Long-Chain Fatty Acid Metabolising Enzymes and Peroxisomal ?-Oxidation.- A Dicarboxylic Metabolite of Tiadenol, Bis(carboxyethylthio)-1,10 Decane, Which Causing Hypolipidemia and Proliferation of Peroxisomes When Administered to Rodents, is Activated to an Acyl-coenzyme A Thioester.- In Vivo and In Vitro Metabolism of Di-(2-ethylhexyl) Adipate, a Peroxisome Proliferator in the Rat.- Allyl Alcohol and Acrolein Toxicity in the Isolated Rat Hepatocytes is Independent of Lipid Peroxidation.- Di-(2-ethylhexyl) Adipate and Peroxisome Proliferation: Identification of Proximate Peroxisomal Proliferator In Vivo and In Vitro.- The Effect of Ethionine on Peroxisome Associated Enzymes.- Immunoaffinity Purification and Comparison of Epoxide Hydrolases from Liver Cytosol and Peroxisomes of Untreated and Clofibrate-Treated Mice.- Induction of Cytosolic and Microsomal Epoxide Hydrolases in Murine Liver by Known Peroxisome Proliferators and Structurally Related Substances.- Enterohepatic Circulation of Fenofibrate Metabolites in the Rat, a Peroxisome Proliferator Responsive Species.- The Effect of Clofibrate Feeding on Enzyme Activities and Mitochondrial Protein Content in Rat Liver and Renal Cortex.- Anticancer Drug Toxicity in the Absence of Hypophyseal or Adrenal Secretion.- Studies on Human Blood Myeloperoxidase and Peroxidase from Rat Uterus, Intestine, and Spleen.- Biotransformations of ?-Picoline in the Rat.- Miscellaneous Toxicity Studies.- Enzymatic and/or Non-Enzymatic “Suicidal” Activation of Carbon Tetrachloride by Haem and Cytochrome P-450.- Method for Assessment of Experimental Allergy in Guinea Pigs Adapted to Cosmetic Ingredients.- Immunotoxicotherapy of Colchicine Poisoning: Toxicological and Pharmacological Features of an Experimental Model Simulating Human Poisoning.- Cardiovascular Actions of Lead in Rats as Related to the Level of Chronic Exposure.- Detection of DNA Damage Induced by Doxorubicin and the Effect of Glutathione.- Chromosome Aberrations in Human Lymphocytes with a New Resin Composite for Aerospace Use.- Testing of 2,4,5- and 2,4,6-Trimethylaniline in the Salmonella Assay, in Mammalian Cell Cultures, and in Drosophila melanogaster and Comparison of the Results with Carcinogenicity Data.- Base Substitution Mutations Induced by the Mycotoxin Citrinin.- Toxicity and Mutagenicity of Patulin in Different Test Systems.- The Combined Acute Toxicity of Lonidamine with Some Other Anticancer Agents or Acetylsalicylic Acid.- Cytotoxicity of Simple Geiparvarin Analogues.- Epoxide Metabolites of Opiates and Their Interaction with the Hepatic Microsomal Epoxide Hydrolase.- Purification and Characterization of Acidic Glutathione S-Transferases (EC 2.5.1.18) from Rat Kidney.- 1,2 Dichloropropane-Induced Liver Toxicity: Clinical Data and Preliminary Studies in Rats.- Induction of Hepatic Metallothionein Following Acetaminophen Administration.- The Effect of Cimetidine or Phenobarbital on the Hepatoxicity of Citalopram in Male Rats.- Quantitative Morphology of Hepatocyte Nuclei in the Comparative Studies of Di(2-ethylhexyl)phthalate Effects.- Organic Solvents Affect Rat Synaptosome Membrane Acetylcholinesterase and Adenosine Triphosphatase In Vitro.- Effect of 2-Methyl-4-chlorophenoxyacetic Acid on Liver Catalase in Chicken Embryos.- ?-Cyclodextrin and Local Muscle Toxicity of Intramuscular Drug Formulations.- Determination of Ethyl Loflazepate, an Anxiolytic Benzodiazepine, in Human Plasma by High-Performance Liquid Chromatography.- Determination of Cocaine in Hair After Repeated Administration to Sheep.- Analysis of Ethanol in Blood: A Comparison of the Abbott TDx TM Ethanol Assay with Gas Chromatography and Chemical Assays.- Comparative Toxicity of Three Quinoxaline-di-N-dioxide Feed Additives in Young Pigs.- Cardiotoxicity of Doxorubicin: A Histochemical and Morphometric Approach.- Inhomogeneous 60Co Whole Body Irradiation of the Göttinger Miniature Swine: A Model for the Study of Long-Term Immunomodulating Effects.- Toxicological Studies with Amrinone.- Puffing Patterns of Smokers Switching to Low-Yield Cigarettes: A Controlled Cross-over Study on Diurnal Changes in Behaviour.- Effect of Pyridinium, 1-{[(3-benzoylpyridinio)-methoxy]methyl}-2-[(hydroxyimino)methyl]-dichloride (HGG 12) on Various Respiratory and Circulatory Parameters of Anesthetized Guinea Pigs.- Comparative Toxicity of Two Trialkylphosphorothioates to Rat Lung and the Effects of Atropine Sulphate Pretreatment.- Urinary Mercury Levels and Renal Function Changes in Dentists and Dental Assistants.- Comparison of the Effects of Sodium N-Benzyl-D-glucamine Dithiocarbamate and Ditripentat on the Toxicity, Excretion, and Tissue Distribution of Cadmium in Mice.- Is the Noxious Hemolytic Effect of Copper a Result of Lipoperoxidation?.- Effects of Cobalt, Indium, and Nickel on 7-Ethoxycoumarin-O-Deethylase in Mice.- Chronic Lead Treatment and Ultrastructure of the Testis in Rats.- Enzyme-Linked Immunosorbent Assay for Detection of Clostridium difficile Toxin B.