Recent Developments in Toxicology: Trends, Methods and Problems: Proceedings of the European Societies of Toxicology Meeting Held in Leipzig, Septembe

ISBN-13: 9783540514220 / Angielski / Miękka / 1991 / 323 str.

European Society of Toxicology; Philip L. Chambers; Claire M. Chambers

Opis

This volume of conference proceedings contains papers on the neurotoxicology of different noxious compounds, new aspects and methods in toxicopathology, cardiovascular toxicology, toxic effects on haemostasis, the liver and the kidney, and miscellaneous toxic effects.

Spis treści

Neurotoxicology of different noxious compounds.- In vitro assessment of antidotes to organophosphorus toxicity.- Primary cultures of adult mammalian sensory neurons and other in vitro systems of use in neurotoxicological studies.- Animal models in behavioural toxicology and teratology.- Cytotoxic brain oedema as a model in the examination of cerebroprotective substances.- Neurochemical characterization of hexachlorophene induced brain oedema.- The effects of organophosphorus compounds on the central nervous system of rats.- The effects of n-hexane and its metabolites on erythrocyte and synaptosome membrane acetylcholinesterease in vitro.- New Aspects and Methods in Toxicopathology.- Assessment of toxicopathological effects in ageing laboratory rodents.- New microtechniques in toxicopathology.- Tumor Registry Data Base: Systematized nomenclature of preneoplastic and neoplastic lesions in rat gonads.- Mortality and neoplastic lesions in untreated Sprague Dawley rats.- Investigations on the sensitivity of several biochemical and histological methods after liver intoxication induced by pentachlorophenol and carbon tetrachloride.- The glutathione system in rat liver chronically injured by thioacetamide.- Hitherto unknown additive growth effects of fluorene and 2-acetylaminofluorene on bile duct epithelium and hepatocytes in rats.- Morphological lesions of pancreas and bile ducts in rats induced by dibutyltin dichloride.- Toxic action of platinum coordination complexes on the endocrine pancreas of the rat.- Investigations of myelotoxic effects in rats.- The effect of aluminium loading on bones of mice.- Cobalt particles, identified by energy dispersive X ray microanalysis, in diamond polisher’s lung.- Density of gastroendocrine cells in cynomolgus monkey and other species.- Computerised analysis of pathological findings in longterm trials of phenylmercuric acetate in rats.- Cardiovascular Toxicology.- Preclinical assessment of the cardiotoxic potential of anthracycline antibiotics: N-L-leucyl-doxorubicin.- Hypertension is not exacerbated by chronic carbon monoxide exposure, with or without added salt, in the borderline hypertensive rat.- Cardiovascular system and kidney as specific targets of chronic exposure to vanadate in the rat: functional and morphological findings.- Acute effects of dichloromethane on arrhythmia development during the early phase of myocardial ischemia and reperfusion in the rat.- Pharmacokinetics of total and free digoxin and Fab fragments in five intoxicated patients after administration of specific anti-digoxin Fab fragments.- Use of spontaneously beating heart muscle cells differentiating from pluripotential embryonic stem cells for testing of chronotropic agents.- Characterization of the hypotensive side effects of macrolide antibiotics in animals.- Toxic Effects on Haemostasis.- Toxic influence on platelet system.- Hereditary and acquired disturbances of haemostasis in animals.- Effects of snake venoms on tissue-type plasminogen activator release.- Metabolic and toxicological studies on the anticoagulant rodenticide, flocoumafen.- Influence of natural humic acids and synthetic phenolic polymers on haemostasis.- A comparison of the thrombogenic activity of prothrombin complex concentrates using stasis and non-stasis models.- Inhibition of platelet aggregation and thromboxane A2 production by chlorophenoxy acid herbicides.- Toxic Effects on Liver and Kidney.- The effect of paracetamol on the hepatic uptake of microparticles in vivo and in vitro.- Influence of iron chelators, 1,2-dialkyl-3-hydroxypyridin-4-ones, on the lipid peroxidation and glutathione level in the liver of mice.- The influence of cytochrome P 450 inducers on carbonyl-reduction in mouse liver.- Influence of inducers of cytochrome P 450 on dealkylation of 7-alkoxycoumarins.- The effect of monoclonal antibodies on dipyrone-induced rat liver cytochrome P 450.- Antipyrine metabolism in coke oven workers.- Influence of bile acids on the development of hepatic transport of organic anions.- Comparative nephrotoxicity studies of cisplatin and its iodinized derivative in rats.- Inhibitory effects of a platelet activating factor antagonist 48740 RP in cyclosporin-induced nephrotoxicity in the rat as assessed by renal glutathione metabolism parameters.- The urinary excretion of specific proteins in workers exposed to lead.- Miscellaneous Toxic Effects.- Reduction of arsenic trioxide toxicity in mice by repeated treatment with glucose.- Effect of oral treatment with BAL, DMPS or DMSA on arsenic in organs of mice injected with arsenic trioxide.- Cyanide antagonism in a rodent model.- The quantitative determination of cadmium in turkish cigarettes.- Modifying role of plasma glucose in acute carbon monoxide poisoning.- Effect of pyrazole on dichloromethane metabolism to carbon monoxide.- Ethylene oxide distribution in human blood.- Distribution of methylene chloride in human blood.- Acute experimental exposures to acetone and ethyl acetate.- Toxic effects of carbon tetrachloride during short and long term ethanol intake in rats.- Effects of pyridinium-1 {[(4-carbamoyl-pyridinio )methoxy ]methyl}-2-(hydroxyiminomethyl) dichloride monohydrate (HI 6) and atropine on the circulation and respiration of anaesthetized guinea pigs.- The mechanism of the anaesthetic action of organic solvents studied with different membrane models in vitro.- An in vivo method to assess the local tolerability of intranasally administered drugs.- Studies on the penetration of tetanus toxoid through the nasal mucosa.- Stobadine toxicity and transplacental movement.- Some effects of furazolidone, humic acid and a combination of both on male reproduction in rats.- Residues of carbadox metabolites in edible pork products.- Pharmacological-toxicological investigations with a furan derivative produced from sugar cane on laboratory animals.- Influence of the degree, position and nature of halide substitution on the rate of photobleaching of xanthene dyes.- Toxicological investigations of waste products from the plasma etching process in the semiconductor industry.- Sister chromatid exchanges in furniture workers exposed to unsaturated polyester resins.- Acute intoxication as a cause of wild bird mortality in the Netherlands from 1975-1989.- Author Index.