Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals: Proceedings of the European Society of Toxicology Meeting Hel

ISBN-13: 9783540124528 / Angielski / Miękka / 1984 / 538 str.

P. L. Chambers; P. Preziosi; C. M. Chambers

Spis treści

Plenary Lecture: Drug-Induced Cardionecrosis.- Young Scientists Award Lecture 1983: Investigations into the Mechanism of Coumarin-Induced Hepatotoxicity in the Rat.- Alteration of Drug Toxicity in Disease States.- Influence of Disease on Drug Toxicity.- Drug Toxicity and Hormonal Dysfunction.- Alterations of Drug Toxicity in Neuropsychiatric Disease States.- Alterations of Drug Toxicity in Cardiovascular Disease.- The Diseased Lung and Drugs.- Lead in Cerebrospinal Fluid in Cerebrovascular Disease: Its Possible Diagnostic, Prognostic and Toxic Significance.- A Comparative Study of Acute Toxicity of Drugs Used During Anticancer Therapy in Healthy and Tumor-Bearing Mice.- Antitumour Drug Toxicity in Pituitary or Adrenal-Ablated Rats.- Tolerance to Pituitary-Adrenal Axis Activation by Anticancer Drugs in Normal and Tumour-Bearing Rats.- Toxins in Hepatic Encephalopathy: The Role of the Synergistic Effect of Ammonia, Mercaptans and Short Chain Fatty Acids.- Toxic Effects on the Male Reproductive System.- Effects of Drugs and Chemicals on Spermatogenesis.- Assessment of Chemicals Affecting the Male Reproductive System.- Toxic and Mutagenic Influences on Spermatogenesis.- Gonadal Damage in Hodgkin's Disease from Cancer Chemotherapeutic Regimens.- Approaches to the Suppression of Testicular Function for Male Fertility Control.- Morphological Changes Produced in Rat Testis by Anticancer Drugs.- Aspects of Testicular Toxicity Induced by Anticancer Drugs.- Changes in Germinal Tissue and Leydig Cells Correlated with Ethanol Consumption in Males with and without Liver Disease.- Testicular Effects of Some Xanthine Derivatives in the Rat.- Effects of Daily High Doses of Paracetamol Given Orally During Spermatogenesis in Rat Testes.- The Effects on the Rat Testis of Single Inhalation Exposures to Ethylene Glycol Monoalkyl Ethers, in Particular Ethylene Glycol Monomethyl Ether.- Effects of an Indenopyridine Derivative, Compound 20-438, on Spermatogonial Stem Cells of the Rat.- Monitoring Chemically Induced DNA Damage in the Germ Cells of Male Mice.- Accumulation of Toxic Metals in Male Reproduction Organs.- Metabolism and Toxicity.- Active Metabolites in Toxicology: The Role of Cytochrome P-448 and Flavoprotein Oxidases.- The Role of Pharmacokinetics in the Design and Interpretation of Toxicological Studies.- Structural Characteristics of Compounds That can be Activated to Chemically Reactive Metabolites: Use for a Prediction of a Carcinogenic Potential.- Covalent Binding to Proteins as a Mechanism of Chemical Toxicity.- Species Differences in Oxidative Drug Metabolism: Some Basic Considerations.- Human Pharmacokinetics and Safety of Boric Acid.- The Influence of Paracetamol on the Hepatic Biosynthesis of Lecithin.- Decreased Blood Levels of Ethanol and Acetaldehyde by S-Adenosyl-L-Methionine in Humans.- Metabolic Activation of 2-Aminofluorene in the Salmonella Mutagenicity Assay by Different S-9 Preparations.- Reduction of Covalent Binding of Aflatoxin B1 to Rabbit Liver DNA After Immunization Against this Carcinogen.- Inactivation of 2-Amino-3-methyl-imidazo (4,5-f) quinoline by Horse Radish and Intestinal Peroxidase.- The Influence of Two Histamine H2-Receptor Antagonists, Cimetidine and Ranitidine, on the Plasma Levels and Clinical Effect of Nifedipine and Metoprolol.- Autoradiography of 2,4?,5-Trichlorobiphenyl Mercapturic Acid Indicates the Formation of Methyl Sulphone Metabolites with Selective Affinity for the Bronchial Mucosa.- Methadone Affects the Histochemical Pattern of Xenobiotic-Metabolizing Enzymes in the Liver of Pregnant Rats.- The Effects of Acetylcysteine on Liver Glutathione Depletion and Hepatic Necrosis Induced by Acetaminophen in Mice.- Increased Microsomal Metabolism of n-Hexane in Rat Kidney and Liver After Inhalation of Isopropanol.- Dose-Dependent Pharmacokinetics of Clofibric Acid in the Non-human Primate.- Different Pathways of Chloroform Metabolism.- In Vitro Inhibition of Lysosomal Phospholipases by Aminoglycoside Antibiotics: A Comparative Study.- Erythrocyte-Dependent Metabolic Activation of Styrene and Induction of Sister Chromatid Exchange in Cultured Human Lymphocytes.- Interaction of Acrylonitrile with the Liver Mixed Function Oxidases.- Induction of Microsomal Enzymes after Inhalation of Methanol.- Erythromycin Estolate Impairs the Mitochondrial and Microsomal Calcium Homeostasis: Correlation with Hepatotoxicity.- Relationships Between the Pharmacokinetics of Carbon Tetrachloride Conversion to Carbon Dioxide and Chloroform and Liver Injury.- Distribution and Metabolism of 2-t-Butyl-4-methoxyphenol in the Everted Rat Gut Preparation.- Phenytoin Metabolites in Human Placental Tissue.- The Placental Transfer and Detection of 14C-Carmoisine Metabolites by HPLC Combined with a Radioactivity Monitor (RAM).- Toxicity of Non-steroidal Antirheumatic Drugs: Molecular Mechanisms and Clinical Assessment.- A Biochemical Basis for the Gastrointestinal Toxicity of Non-steroid Antirheumatoid Drugs.- Molecular Mechanisms of the Gastric Toxicity of Antirheumatic Drugs.- Mechanisms of the Nephrotoxicity of Non-steroidal Anti-inflammatory Drugs.- Clinical Assessment of the Renal Toxicity of Antirheumatic Drugs.- Central and Peripheral Haemodynamic Effects of Non-steroidal Anti-inflammatory Drugs in Man.- Indomethacin Induced Intestinal Toxicity is Blocked by Sodium Salicylate at 24 and 48 Hours Post Treatment.- The Preclinical Toxicity of Dazoxiben: A Specific Inhibitor of Thromboxane A2 Synthetase.- Species Differences in the Acute Toxicity of Non-steroidal Anti-inflammatory Compounds.- Heavy Metal Toxicity.- Renal Handling of Cadmium: A Study by Tubular Microinjections.- Cadmium Alters Arterial Baroreflex Control of Heart Rate in the Conscious Rat.- Inhibition of Aortic Vessel Adenosine Diphosphate Degradation by Cadmium and Mercury.- Embryotoxic Action Induced by Mercury Acetate in the Rat.- Cardiovascular Homeostasis in Rats Chronically Exposed to Mercuric Chloride.- The Effects of a Dose of Mercuric Chloride, Below the Acute Toxic Dose, on Haemostasis in Rats.- In Vitro Cytotoxicity of Nickel Chloride on a Human Pulmonary Epithelial Cell Line (A 549).- Changes in Endogenous Monoamine Levels of Rat Brain Induced by Tetraethyl Lead.- Levels of Monoamines in Different Regions of the Rat Brain in Heavy Metal Intoxication.- Xenobiotic Toxicology.- Experimental Evidence on the Pulmonary Carcinogenicity of Arsenic Trioxide.- Molecular Interaction of Acrylonitrile at Target Sites of Carcinogenicity in Rats.- Mutagenic Activity of Nitriloacetic Acid.- Neurotoxicity in Rats Dosed with Peppermint Oil and Pulegone.- Neurotoxicological Profile of Carbon Disulphide After Intraventricular Administration in Rats.- Immediate Effects of m-Xylene on the Human Central Nervous System.- Potentiation of Hexane and Organophosphate Neurotoxicities.- Behavioural and Electrocortical Spectrum Power Changes After Intraventricular Injection of Patulin in Rats.- The Effects of Radiological Contrast Media on the Reproduction System of the Rat.- Short-term Studies with the Cryptating Agent Hexaoxa-diaza-bicyclo-hexacosane in Rats.- Evaluation of the Toxicological Risk in Animals Following the Ingestion of Cheese Obtained from Milk with Added Formaldehyde.- The Influence of Soil Particle Adsorption on 2,3,7,8-Tetrachlorodibenzo-p-dioxin Biological Uptake in the Rabbit.- The Subchronic Toxicity of 3,5-Dinitro-4-chloro-?,?,?-trifluorotoluene in the Rat.- Trihalomethane in Drinking Waters: A Statistical Study.- Inhalation Toxicology: Correlation Between the Concentration of the Test Compound and the Exposure Time Using Carbon Tetrachloride.- Circulating Concentrations of Testosterone, Luteinizing Hormone and Follicle Stimulating Hormone in Male Rats After Inhalation of Methanol.- The Effect of Sodium Selenite on Respiratory Function in Mitochondria Isolated from Guinea Pig Heart.- Intestinal Absorption and Excretion of Thallium (201Tl) in the Rat.- Evaluation of Pollution Levels by Analysis of the Pesticide Residues in Algerian Sheep.- Miscellaneous Toxic Effects.- A 2?Guanidyl Derivative of Gentamicin (S86451) with Reduced Nephrotoxicity: Studies at Low and Medium Dose Levels in the Rat.- Tubular Regeneration in Rat Kidney Cortex During Treatment with Gentamicin at a Low Dose.- Aminoglycoside Antibiotics: A Study of Their Neurotoxic Effects at Peripheral Nerve Fibres.- The Use of Physostigmine in Heroin Overdose.- 4-Aminopyridine: An Anticurare and Reawakening Drug.- The Influence of Dose Schedules and Administration Routes on the Toxicity of Potential Antiviral Drugs.- Intramuscular Injections and Muscle Damage: Effects of Concentration, Volume, Injection Speed and Vehicle.- Evidence of an Interaction Between Opioids and Histaminergic Systems on Cannabis Sativa-Induced Catalepsy.- Fever Reaction of Rabbits After Repeated Intravenous Injections of Antigens.- Cardiovascular Effects of Tetanus Toxin After Systemic and Intraventricular Administration in Rats.- The Incidence of Drug Overdosage in Patients Admitted to General Hospitals in the Canary Islands.- The Toxic Effects of Clofibrate and Its Metabolite on Mammalian Skeletal Muscle: An Electrophysiological Study.- A Comparative Retrospective Analysis of Data from Short- and Long-Term Animal Toxicity Studies on 40 Pharmaceutical Compounds.- Cardiac Hypertrophy in the Dog and Rat Induced by Oxfenicine, an Agent Which Modifies Muscle Metabolism.- An Epidemic of a "New" Haemorrhagic Disease in Infants Attributable to Talcum Powder Contaminated with Warfarin in Ho-Chi-Minh Ville (Vietnam).- Stress, Drugs, and Pregnancy: Experimental Studies on Embryo-Foetal Toxicity.- Long-Lasting Hypothermic Effects of Vincristine in Rats.- Behavioural Changes in Rats After Prenatal Administration of Typical and Atypical Antidepressants.- Side Effects of Drugs Stimulating Prolactin Secretion on the Behavior of Male Rats.- Possible Adverse Effects on the Cardiovascular System of an Antiarrhythmic Drug Mexiletine.- Novel and New Techniques in Toxicology.- A Single Step Method for the Separation of Rat Liver Cytosolic Glutathione S-Transferase Isozymes.- In Vitro Mouse Fertilization as an Experimental Model for the Monitoring of Adverse Effects on Gametes and Gamete Fusion.- Repeat Dermal Models for Systemic Toxicity: A Comparison of the Rabbit, Rat and Guinea Pig.- A New Cation-Exchange and Thin Layer Chromatography Technique for the Identification of Pethidine in Urine.- Author Index.