Toxic Interfaces of Neurones, Smoke and Genes: Proceedings of the European Society of Toxicology Meeting Held in Kuopio, June 16-19, 1985

ISBN-13: 9783540165897 / Angielski / Miękka / 1986 / 487 str.

Philip L. Chambers; Jouko Tuomisto; Claire M. Chambers

Spis treści

Neural Membranes as a Target of Toxicity.- Nerve Membrane Ionic Channels as the Target of Toxicants.- Neurochemical Effects of DDT in Rat Brain In Vivo.- The Pharmacology of Simple Molecules.- Membrane Lipid Changes in Organic Solvent Tolerant Neural Cells.- Effects of Methylglyoxal on Central and Peripheral Cholinergic Responses.- Effects of Diazepam, Tofizopam or Phenytoin During Foetal Development on Subsequent Behaviour and Benzodiazepine Receptor Characteristics in Rats.- The Effect of Ethanol on the Release of Free Fatty Acids from the Brain In Vivo; A study with a Push-Pull Cannula.- Aspects of Smoke Toxicology.- Review of Epidemiology in Relation to Passive Smoking.- Aerosols of Smoke, Respiratory Physiology and Deposition.- Monitoring Absorption by Means of Determination of Nicotine and Cotinine.- Monitoring Urine for Inhaled Cannabinoids.- Microcomputer Assisted Measurement of Inhalation Parameters During Smoking.- No Difference Between Urinary Mutagenicity in Smokers of Low-Tar and Medium-Tar Cigarettes: A Double Blind Cross-Over Study.- Cigarette Smoking, Serum Lipids and Angiographically Assessed Coronary Artery Disease.- Genetic Influences on Toxicity.- The Case for Isogenic strains in Toxicological Screening.- Polymorphism in Drug Metabolism — Implications for Drug Toxicity.- Inter-Individual Variations in Carcinogen Metabolism.- Interethnic Differences in the Detoxification of Organophosphates: The Human Serum Paraoxonase Polymorphism.- DNA-Mediated Restoration of Aryl Hydrocarbon Hydroxylase Induction in a Mouse Hepatoma Mutant Defective in Nuclear Translocation of the Ah Receptor.- Species Differences in the Covalent Binding of p-Chloro-o-Toluidine to DNA.- Effects of Peroxisome Proliferators In Vivo and in Primary Hepatocyte Cultures from Chinese and Syrian Hamsters.- Cardiovascular Toxicity.- Cardiotoxicity Mechanisms from the Point of View of Preclinical or Premarketing Safety Evaluation.- Detection of Cardiotoxic Hazards.- Interaction of Calcium Antagonists with ?-Adrenoceptor Blocking Agents.- Cardiotoxicity of Digitalis.- Cardiotoxic Actions of Doxepin and Barium Chloride in Conscious Rabbits.- Dose Dependence of the Nifedipine/Digoxin Interaction?.- Experimental Compound OR-K-242-HCL, an Anilide Derivative Slows Conduction Velocity of the Heart in the Conscious Beagle Dog.- Nifedipine Induces Intense Nausea and Vomiting in Young Healthy Volunteers.- The Effect of a Novel Inotropic/Vasodilating Compound on the Dog Heart at Toxicological Doses.- Routine Toxicity Testing: Problems and Solutions.- Toxicology — The Next Decade.- Application, Limitations and Research Requirements of In Vitro Test Systems in Toxicology.- The Questionable Value of Long-Term Animal Toxicity Studies: A Regulatory Dilemma.- To what Extent can Results of Experimental Studies be Extrapolated in Predicting Adverse Side Effects of Drugs in Man.- Validity of Toxicity Documents of Pesticides and Good Laboratory Practice.- Carcinogenicity Testing in Nude Mouse Cell Cultures.- Pharmacokinetically Governed Design of Animal Toxicity Studies of a New Antidepressant Drug.- Dog and Swine as Models for Testing Indomethacin Induced Gastrointestinal Irritation.- A Rapid Method for Quantitation of Toxic Heart Dilation in Rats.- On the Usefulness of Minipigs in Toxicological Testing of Pesticides.- Cellular Mechanisms of Toxicity.- Cellular Defense Mechanisms against Toxic Substances.- Differences in the Induction of Autoimmune Responses in A. SW/SnJ Mice by Various Agents.- Morphological Alterations induced by Patulin on Cultured Hepatoma Cells.- The Effects of Estrogen and Antiestrogens on Light-Induced Retinal Damage in Rat.- Reaction Products of Styrene Oxide with Deoxynucleosides and DNA In Vitro.- Binding of Styrene Oxide to Amino Acids, Human Serum Proteins and Hemoglobin.- Cytogenetic Effects of a Novel Antiestrogen Toremifene FC-1157a: A Comparison with Diethylstilbestrol and Tamoxifen.- Toxicity of Richterite in Hemolysis Test and Macrophage Cultures.- Prajmaline, an Antiarrhythmic Drug, Depresses the Hepatic Glutathione System in Rats.- Effects of Diethyl Maleate on Non-protein Sulfhydryl Content and Cellular Functions of Mouse Thymocytes In Vitro.- Toxic and Protective Effects of Antioxidants in Biomembranes.- Reduction of Gentamicin Nephrotoxicity by the Concomitant Administration of Poly-L-Aspartic acid and Poly-L-Asparagine in Rats.- Effect of Ochratoxin A on Enzyme Activities and Macromolecules Synthesis in MDCK Cells.- Mushroom Poisoning due to Cortinarius Speciosissimus: Electron Microscope Study in Rats.- Effect of Organic Solvents on Human Erythrocyte Membrane Acetylcholinesterase Activity In Vitro.- Vinyl Acetate, a Structural Analog of Vinyl Carbamate, Fails to Induce Enzyme Altered Foci in Rat Liver.- Pesticides and Related Compounds.- Pyrethroid Metabolism: Studies on Cis- and Trans-Phenothrins, and Related Epoxide Intermediates.- Effects of Antidotes on Soman-Induced Brain Changes.- Experimental Studies on Dimethoate Oxidative Desulphuration.- Gas Chromatographic Determination of Myo-Inosital Phosphates: Evaluation of Various Methods.- Ethylenthiourea and Nabam Induced Alterations of Function and Morphology of Thyroid Gland in Rats.- Peripheral and Central Nervous System Effects of Nabam and Ethylenethiourea in Rats.- Induction of Hepatic Microsomal Mixed Function Oxidase System by Ethylenethiourea in Mice.- Effects of Zineb on Hepatic Microsomal Systems in Rats and Mice.- In Vitro Formation of N-Nitroso Curzate: Effect of Nitrosation Modulators.- Probenecid Affects the Toxicity and Concentration of Chlorophenoxyacetic Acids in the Rat Brain.- The Central Nervous System Toxicity of Chlorophenoxyacetic Acid Herbicides.- Brown Adipose Tissue is a Target Tissue in 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Induced Toxicity.- Stereochemical Considerations on the Inhibition of Hepatic Epoxide Hydrolase by Some Pesticides and Their Epoxides.- Xenobiotic Metabolism.- Inhibition by Methylglyoxal Bis (Guanylhydrazone) of Drug Oxidation Reactions Catalyzed by Mouse Liver Microsomes In Vivo and In Vitro.- Coumarin 7-Hydroxylase in Inbred Strains of Mice: Comparison with Other Microsomal Monooxygenase Activities and Induction by Pyrazole.- Inhibition of Microsomal Monooxygenases In Vitro by Aromatic Hydrocarbons.- Induction of Cytochrome P-450 Mediated Mono-oxygenase Reactions and Conjugated Activities in Freshwater Crayfish. (Astacus astacus).- Monooxygenase Activity of Fish Liver in Biomonitoring Aquatic Environments.- Influence of Age, Hexobarbital and Aniline on NADPH/NADH Dependent Hydrogen Peroxide Production in Rat Hepatic Microsomes.- Structure Activity Studies on the Induction of Peroxisomal Enzyme Activities by a Series of Phthalate Monoesters in Primary Rat Hepatocyte Cultures.- Heavy Metal Toxicity.- Studies on the Inhibition of Brain Synaptosomal Na+/K+-ATPase by Mercury Chloride and Methyl Mercury Chloride.- Lead does not affect Calmodulin-induced Activation of Calcium-dependent Adenosine Triphosphate in Human Red Blood Cell Membranes.- Effect of Some Heavy Metal Salts on Lipid Peroxidation After Acute Intoxication and Subchronic Exposure.- Triphenyl Tin Hepatotoxicity in Rats.- Toxicity of Iceland Lichen and Reindeer Lichen.- Metal Pollution in a Salt Marsh and its Effect on Sheep.- Changes of Vascular Reactivity Induced by Lead.- Cardiotoxic and Bronchoconstrictor Effects of Industrial Metal Fumes Containing Barium.- Immunological Unresponsiveness to Chromium or Nickel in the Guinea-Pig Induced by Stainless Steel Welding Fume Components.- Miscellaneous Toxicological Topics.- Structure-Activity Relationship of Nitroimidazo (2,1-b) Thiazoles in the Salmonella Mutagenicity Assay.- Erythrocyte-Dependent Metabolic Activation of 2-Amino-Fluorene in Salmonella Mutagenicity Assay.- Sulphur Dioxide Induced Bronchitis in Rats.- Perfused and Ventilated Guinea Pig Lung: A Method for Evaluating Xenobiotic Effects on Arachadonic Acid. Effects of Formaldehyde.- Retardation of Spermiation Following Short-Term Treatment of Rats with Theobromine.- Assay of Possible Formation of Antigenic Components in Heat-Treated Plasma Protein Preparations.- Histopathological and Morphometrical Analysis Applied to Skin Changes in NMRI Mice Induced by Dithranol (Anthranil) and its Acyl Analogs.- Variable Effects of Irritants (Methylmethacrylate, Terphenyls, Dithranol and Methylglyoxal-Bis-Guanylhydrazone) on the Fine Structure of the Epidermis.- Electron Microscopy and Immunohistochemistry of Toxic and Allergic Effects of Methylmethacrylate on the skin.- Occupational Exposure to Chlorinated Organic Solvents and its Effect on the Renal Excretion of N-Acetyl-Beta-D-Glucosaminidase.- Toxicity and Kinetics of Perfluoro-Octanoic Acid in the Wistar Rat.- Toxicity Studies on a New Aspirin Pro-Drug.- Adrenocortical Activation is Independent from Systemic Toxicity in Long-Term Hydroxyurea Treatment.- Neuroendocrine (Carcinoid) Tumours of the Glandular Stomach of the Rat Following Treatment with an H2-Receptor Antagonist.- Dihydroergotamine — A Toxicological and Pharmacokinetic Study in Cynomolgus Monkeys Following Administration by the Intra-Nasal Route.- Effects of Exercise and Physical Fitness on Theophylline Half-Life in Rats.- Determination of Doxorubican and Doxorubicin-3-ol in Rat Heart.- Author Index.