Health Effects of Tea and Its Catechins
ISBN: 9781441934314 / Angielski / Miękka / 118 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. During the course of the last two decades, the health effects of tea and its catechins have been docmnented in nmnerous scientific studies and the scientific basis of these effects has been elaborated. Professor Kuroda and Dr. Hara provide in this volmne a translation of a thorough and extensive book published earlier (in Japanese), which will be of considerable interest to scientists worldng in the field, and to members of the general public interested in naturaJ ways of maintaining health. Both authors are themselves eminent researchers with extensive experience. Dr. Kuroda is best known...
During the course of the last two decades, the health effects of tea and its catechins have been docmnented in nmnerous scientific studies and the sci...
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382,84 zł |
Cell Culture Methods for in Vitro Toxicology
ISBN: 9789048159369 / Angielski / Miękka / 153 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Cell Culture Methods for in vitro Toxicology introduces the reader to a range of techniques involved in the use of in vitro cell culture in toxicological studies. It deals with major cell types studied in the field of toxicology and will be useful for anyone wishing to start work with animal cell cultures or to refresh their knowledge relating to in vitro cell models. Fundamental chapters deal with the general biology of cytotoxicity and cell immortalisation these are key issues for in vitro systems addressing the 3Rs' principle. Up-to-date overviews deal...
Cell Culture Methods for in vitro Toxicology introduces the reader to a range of techniques involved in the use of in vitro cell cul...
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382,84 zł |
High Dilution Effects: Physical and Biochemical Basis
ISBN: 9789048166015 / Angielski / Miękka / 130 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Since the subject of high dilution effects is still a subject for debate, this volume provides evidence in support of effects from control clinical studies, clinical records from veteran physicians, controlled experiments on animals and plants, and in vitro tests without any organisms (Chapter II). An overview of the methods for preparing drugs at ultra high dilution is also provided as well as the basic principles of homeopathy, which has been alleviating human suffering through the use of these drugs for several hundred years (Chapter I). Chapter III provides physical basis of high...
Since the subject of high dilution effects is still a subject for debate, this volume provides evidence in support of effects from control clinical st...
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382,84 zł |
Essential Concepts in Toxicogenomics
ISBN: 9781617376887 / Angielski / Miękka / 277 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The field of toxicogenomics is moving rapidly, so it is impossible at the timeofthiswritingtocompileaclassicmethodstextbook.Instead, wechose to identify experts in all aspects of this field and challenged them to write reviews, opinion pieces, and case studies. This book covers the main areas important to the study and use of toxicogenomics. Chapter 1 speaks to the convergenceofclassicapproachesalongsidetoxicogenomics.Chapter2deals withtheusefulnessoftoxicogenomicstoidentifythemechanismoftoxicity. Chapter3callsattentiontotheissuesthataffectthequalityoftoxicogenomics experiments, as well as...
The field of toxicogenomics is moving rapidly, so it is impossible at the timeofthiswritingtocompileaclassicmethodstextbook.Instead, wechose to identi...
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382,84 zł |
Receptor Binding Techniques
ISBN: 9781617375569 / Angielski / Miękka / 240 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A comprehensive collection of readily reproducible methods for studying receptors in silico, in vitro, and in vivo. These cutting-edge techniques cover mining from curated databases, identifying novel receptors by high throughput screening, molecular methods to identify mRNA encoding receptors, radioligand binding assays and their analysis, quantitative autoradiography, and imaging receptors by positron emission tomography (PET). Highlights include phenotypic characterization of receptors in knockout mice, imaging receptors using green fluorescent protein and fluorescent resonance energy...
A comprehensive collection of readily reproducible methods for studying receptors in silico, in vitro, and in vivo. These cutting-edge techniques cove...
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382,84 zł |
Liposome Methods and Protocols
ISBN: 9781617372179 / Angielski / Miękka / 252 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In vitro utilization of liposomes is now recognized as a powerful tool in many bioscience investigations and their associated clinical studies, e.g., liposomes in drug targeting; liposomes in gene transport across plasma and nuclear membranes; liposomes in enzyme therapy in patients with genetic disorders. However, before these areas can be effectively explored, many basic areas in liposome research require elucidation, including: (a) attachment of liposomes to cell surfaces; (b) permeation of liposomes through the plasma membranes; and (c) stability of liposomes in cell or nuclear matrices....
In vitro utilization of liposomes is now recognized as a powerful tool in many bioscience investigations and their associated clinical studies, e.g., ...
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382,84 zł |
Methods in Biological Oxidative Stress
ISBN: 9781617372001 / Angielski / Miękka / 216 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Oxidative damage appears to play a central role in the development of a wide range of tissue pathology, including neurodegenerative disease, drug side-effects, xenobiotic toxicity, carcinogenesis, and the aging process, to name just a few. Because of the centrality of oxidative processes to normal and abnormal tissue function, it has become imperative to develop appropriate analytical techniques to facilitate the quantitation of significant reactants. Without advances in methodology, corresponding advances in our knowledge of underlying biochemical events will be necessarily limited. Drs....
Oxidative damage appears to play a central role in the development of a wide range of tissue pathology, including neurodegenerative disease, drug side...
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382,84 zł |
Diagnostic and Therapeutic Antibodies
ISBN: 9781617371950 / Angielski / Miękka / 477 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer. Antibodies appeared to offer the magic bullet that would allow the specific destruction of neoplastic cells. H- ever, many years effort resulted in very few cases of successful immu- therapy with antibodies. As a result there was a major backlash against antibody therapy, and the field lost a considerable amount of popularity. Fashion, in science as well as in other things, tends to be cyclical. Antibody-based therapy is...
Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially i...
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382,84 zł |
Peptidomimetics Protocols
ISBN: 9781617370595 / Angielski / Miękka / 549 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Many physiologically important receptors and enzymes are regulated by their endogenous ligands and inhibitors. Nature chose to utilize these p- tides as chemical switches since they can be efficiently synthesized and - graded in cells, thus providing an immediate response to a fast changing environment. Such properties, so critical in cell survival, make peptides less than ideal drug candidates. Other frequently desired properties in drug m- ecules include oral bioavailability, the ability to cross membranes, including the blood-brain barrier, and sufficient stability for administration 1-2...
Many physiologically important receptors and enzymes are regulated by their endogenous ligands and inhibitors. Nature chose to utilize these p- tides ...
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382,84 zł |
Pharming: Promises and Risks Ofbbiopharmaceuticals Derived from Genetically Modified Plants and Animals
ISBN: 9783642099359 / Angielski / Miękka / 334 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A recently established technique termed pharming uses genetically modified plants and animals for the production of biopharmaceuticals. The present interdisciplinary study comprises an extended overview of the state of the art of pharming, as well as in depth analyses of the environmental risks and other ethical and legal issues of pharming. Public attitudes to pharming are investigated on the basis of an original survey in 15 countries worldwide. The study concludes with specific recommendations addressed towards science, industry and politics.
A recently established technique termed pharming uses genetically modified plants and animals for the production of biopharmaceuticals. The present... |
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382,84 zł |
Pharmaco-Complexity: Non-Linear Phenomena and Drug Product Development
ISBN: 9781441978554 / Angielski / Miękka / 71 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The interpretation of physical, chemical and biological phenomena as linear relationships between variables, or as simple functions of the variables, has been a significant scientific and mathematical strategy to their elucidation for centuries. It is often the case that the nature of linearity is to follow mathematical functions, e.g. power, exponential or logarithmic functions, nevertheless the desire to fit data to simple predictable expressions is imbued in every scientist and engineer. From a philosophical standpoint there is no reason to criticize this approach as it allows us to... The interpretation of physical, chemical and biological phenomena as linear relationships between variables, or as simple functions of the variable... |
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Long-Term Studies on Side-Effects of Contraception -- State and Planning: Symposium of the Study Group 'Side-Effects of Oral Contraceptives -- Pilot P
ISBN: 9783540090939 / Angielski / Miękka / 240 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Conference reports of scientific meetings do not automatically justi fy publication. Our decision to publish the Proceedings of this Sym posium was based on a number of reasons. The subject of more or less grave adverse side-effects of oral contra ception is of major importance for all women. If the research insti tutions of Gynecology make fundamental mistakes in this subject, then the trust in them will diminish substantially. National institutions will have to shoulder a part of that burden, too, if they do not suc ceed in timely prevention of grave and widespread health risks and damages....
Conference reports of scientific meetings do not automatically justi fy publication. Our decision to publish the Proceedings of this Sym posium was ba...
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382,84 zł |
Toxicology in the Use, Misuse, and Abuse of Food, Drugs, and Chemicals: Proceedings of the European Society of Toxicology Meeting, Held in Tel Aviv, M
ISBN: 9783540123927 / Angielski / Miękka / 406 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Many chemotherapeutic agents introduced for use in humans are carcinogenic in laboratory animals (Conklin et al. 1965; Shimkin et al. 1966; Griswold et al. 1968; Harris 1976). However, initially their beneficial effect in disseminated cancer was of such short duration that the inevitable death of the patient from his primary disease precluded any clinical manifestation of the carcinogenic potential. During the last decade, chemotherapy has radically changed the outlook for many patients with cancer. Combinations of drugs, administered as the primary treatment, have resulted in high rates of...
Many chemotherapeutic agents introduced for use in humans are carcinogenic in laboratory animals (Conklin et al. 1965; Shimkin et al. 1966; Griswold e...
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382,84 zł |
Disease, Metabolism and Reproduction in the Toxic Response to Drugs and Other Chemicals: Proceedings of the European Society of Toxicology Meeting Hel
ISBN: 9783540124528 / Angielski / Miękka / 538 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
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Receptors and Other Targets for Toxic Substances: Proceedings of the European Society of Toxicology, Meeting Held in Budapest, June 11-14, 1984
ISBN: 9783540136705 / Angielski / Miękka / 520 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Trichloroethylene (TRI), administered orally at high doses for 18 months has been shown to increase the incidence of hepatocellular carcinoma in B6C3F 1 mice but not Osborne-Mendel rats (NCI, 1976). The interpretation of these studies has been confounded due to the presence of epoxide stabilizers in the TRI. However more recent studies have demonstrated that pure TRI also causes hepatocellular carcinoma in B6C3F mice (NTP, 1983) and Aldedey Park (Swiss) mice (Elcombe 1 and Pratt, unpublished data). Furthermore, no increase in the incidence of hepatocellular carcinoma was observed in Fisher...
Trichloroethylene (TRI), administered orally at high doses for 18 months has been shown to increase the incidence of hepatocellular carcinoma in B6C3F...
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382,84 zł |
Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards: The Use of Short-Term Tests for
ISBN: 9783540136965 / Angielski / Miękka / 197 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The International Life Sciences Institute (lLSI) is a scientific foundation wh ich addresses critical health and safety issues of national and international concern. ILSI promotes international cooperation by pro viding the mechanism for scientists from government, industry and universities to work together on cooperative programs to generate and disseminate scientific data. The members and trustees of the Institute believe that questions regarding health and safety are best resolved when scientists can ex amine and discuss issues, as an independent body, se arate from the political pressures...
The International Life Sciences Institute (lLSI) is a scientific foundation wh ich addresses critical health and safety issues of national and interna...
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382,84 zł |
Toxic Interfaces of Neurones, Smoke and Genes: Proceedings of the European Society of Toxicology Meeting Held in Kuopio, June 16-19, 1985
ISBN: 9783540165897 / Angielski / Miękka / 487 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
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The Target Organ and the Toxic Process: Proceedings of the European Society of Toxicology Meeting Held in Strasbourg, September 17-19, 1987
ISBN: 9783540185123 / Angielski / Miękka / 462 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
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Rökan: Ginkgo Biloba Recent Results in Pharmacology and Clinic
ISBN: 9783540192619 / Angielski / Miękka / 365 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In this compendium the clinical and pharmacological properties of Ginkgo biloba, a standardized drug and the subject of increasing worldwide interest, are closely portrayed. Results of studies are presented here which illustrate the influence of Ginkgo on haemodynamic and rheologic parameters, metabolism and neurotransmitters. In addition to papers reporting on experimental research, data are also presented which provide firm interdisciplinary evidence for its successful therapeutic application, above all in the following indication areas: cerebral insufficiency with accompanying symptoms of...
In this compendium the clinical and pharmacological properties of Ginkgo biloba, a standardized drug and the subject of increasing worldwide interest,...
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382,84 zł |
Prostaglandin E1: New Aspects on Pharmacology, Metabolism and Clinical Efficacy
ISBN: 9783540545248 / Angielski / Miękka / 117 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Although prostaglandin El (PGE ) has been clinically available for a long 1 time, only in recent years has its effectiveness in peripheral arterial occlusive disease been confirmed in controlled studies. Not surprisingly, the favour able results achieved both in patients with critical limb ischaemia and in those with intermittent claudication has stimulated research activities into the clinical pharmacology of this prostaglandin. As a consequence of these efforts, exciting new findings have revealed that PGE has anti thrombotic, endothelium-stabilizing and leucocyte-stabi 1 lizing properties...
Although prostaglandin El (PGE ) has been clinically available for a long 1 time, only in recent years has its effectiveness in peripheral arterial oc...
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382,84 zł |