Reviews of Physiology, Biochemistry and Pharmacology 157
ISBN: 9783540396888 / Angielski / Twarda / 140 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
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382,84 zł |
Gpcrs: From Deorphanization to Lead Structure Identification
ISBN: 9783540489818 / Angielski / Twarda / 269 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006, the book highlights the following topics: Structure of GPCRs, Design of GPCR Ligands, GPCR Signalling, Deorphanization and Assay Development. All chapters are written by leading experts in the field, discussing the most recent state of the art. They give insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. The book reflects the actual... Based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006, the... |
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382,84 zł |
G Protein-Coupled Receptors in Drug Discovery
ISBN: 9781603273169 / Angielski / Twarda / 376 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The G protein-coupled receptors (GPCRs) and associated peripheral G proteins underpin a multitude of physiological processes. The GPCRs represent one of the largest superfamilies in the human genome and are a significant target for bioactive and drug discovery programs. It is estimated that greater than 50% of all drugs, including those in development, currently target GPCRs. Many of the characterized GPCRs have known ligands; however, approximately 20% of GPCRs are described as orphan GPCRs, apparent GPCRs that share the generic high-level structure charact- istic of GPCRs but whose...
The G protein-coupled receptors (GPCRs) and associated peripheral G proteins underpin a multitude of physiological processes. The GPCRs represent one ...
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382,84 zł |
Prediction of Neuroleptic Treatment Outcome in Schizophrenia: Concepts and Methods
ISBN: 9783211826027 / Angielski / Miękka / 216 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Prognosis is a core concept in psychiatry. This book is concerned with prediction of neuroleptic treatment outcome in schizophrenia from a conceptual and methodological point of view. Various aspects of the topic, such as definition and measurement of response, dimensions of treatment outcome, neuropsychological, neuropsychopharmacological and neurobiochemical predictors as well as the clinical application of neuroimaging methods and neurogenetics are treated by experts in the field. One aim of the book is to summarize the present state of the art in prediction research and thereby to provide...
Prognosis is a core concept in psychiatry. This book is concerned with prediction of neuroleptic treatment outcome in schizophrenia from a conceptual ...
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382,84 zł |
Medical Treatment of Intoxications and Decontamination of Chemical Agents in the Area of Terrorist Attack
ISBN: 9781402041693 / Angielski / Miękka / 214 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book includes reports which were presented at a NATO Advanced Research Workshop (ARW) entitled Medical Treatment of Intoxications and Decontamination of Chemical Agent in the Area of Terrorist Attack . The workshop was held on 25-28 January 2005 in Dnepropetrovsk, Ukraine. Currently, scientists and experts from many countries are working on development and implementation of a readiness for anti terrorist actions. In addition to chemical weapons, terrorists can use various toxic chemicals from chemical industry, agriculture or products released from terrorist acts on industrial...
This book includes reports which were presented at a NATO Advanced Research Workshop (ARW) entitled Medical Treatment of Intoxications and Decontamina...
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382,84 zł |
Medical Treatment of Intoxications and Decontamination of Chemical Agents in the Area of Terrorist Attack
ISBN: 9781402041686 / Angielski / Twarda / 214 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book includes reports which were presented at a NATO Advanced Research Workshop (ARW) entitled Medical Treatment of Intoxications and Decontamination of Chemical Agent in the Area of Terrorist Attack . The workshop was held on 25-28 January 2005 in Dnepropetrovsk, Ukraine. Currently, scientists and experts from many countries are working on development and implementation of a readiness for anti terrorist actions. In addition to chemical weapons, terrorists can use various toxic chemicals from chemical industry, agriculture or products released from terrorist acts on industrial...
This book includes reports which were presented at a NATO Advanced Research Workshop (ARW) entitled Medical Treatment of Intoxications and Decontamina...
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382,84 zł |
Health Effects of Tea and Its Catechins
ISBN: 9780306482076 / Angielski / Twarda / 118 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. During the course of the last two decades, the health effects of tea and its catechins have been docmnented in nmnerous scientific studies and the scientific basis of these effects has been elaborated. Professor Kuroda and Dr. Hara provide in this volmne a translation of a thorough and extensive book published earlier (in Japanese), which will be of considerable interest to scientists worldng in the field, and to members of the general public interested in naturaJ ways of maintaining health. Both authors are themselves eminent researchers with extensive experience. Dr. Kuroda is best known...
During the course of the last two decades, the health effects of tea and its catechins have been docmnented in nmnerous scientific studies and the sci...
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382,84 zł |
Extravasation of Cytotoxic Agents: Compendium for Prevention and Management [With CDROM]
ISBN: 9783211888896 / Angielski / Twarda / 412 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The extravasation of cytotoxic agents can result in severe local tissue damage and medical emergencies during tumour therapy. This revised compendium is intended to help clinicians assess any situation speedily and with certainty. The general section of the book includes topics such as predisposition, prevention, type of harm, general measures in handling extravasated drugs, specific antidotes, and documentation. In the 2nd edition, the scientific information contained in the general section and relating to the actual substances has been updated. The substance specific part of the book... The extravasation of cytotoxic agents can result in severe local tissue damage and medical emergencies during tumour therapy. This revised compendi... |
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382,84 zł |
Drug-Related Problems in the Elderly
ISBN: 9789048124459 / Angielski / Twarda / 135 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The number of elderly is increasing in the developed part of the world. With increasing age the prevalence of many diseases will increase. This promotes high use of drugs. For all health care professionals, it is essential to be aware of the possible risks and difficulties with drugs in the elderly. In this book, the authors describe these difficulties from several aspects. Evidence based medicine and elderly, physiological alterations with age that affects pharmacology, specific conditions and drugs that are troublesome in the elderly as well as organisational shortcomings are covered.... The number of elderly is increasing in the developed part of the world. With increasing age the prevalence of many diseases will increase. This pro... |
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382,84 zł |
Chemogenomics: Methods and Applications
ISBN: 9781607612735 / Angielski / Twarda / 320 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Chemogenomics aims toward the systematic identification of small molecules that interact with the products of the genome and modulate their biological function. The establishment, analysis, prediction, and expansion of a comprehensive ligand target SAR (structure activity relationship) matrix has followed the elucidation of the human genome and presents a key scientific challenge for the twenty-first century. The anno- tion and knowledge-based exploration of the ligand target SAR matrix is then expected to impact science greatly. Progress alongside this challenge without a doubt will c-...
Chemogenomics aims toward the systematic identification of small molecules that interact with the products of the genome and modulate their biological...
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382,84 zł |
Ligand-Macromolecular Interactions in Drug Discovery: Methods and Protocols
ISBN: 9781607612438 / Angielski / Twarda / 297 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Drug research has been greatly transformed by the "omics revolution" and advances in computational tools, combinatorial chemistry, and high throughput screening techniques (HTS). These implements have advanced the ability to identify target molecules that serve as points of attack for future medicines, the design and synthesis of potential lead compounds, and further characterization, screening, and assays for therapeutic efficacy and toxicity. In Ligand-Macromolecular Interactions in Drug Discovery: Methods and Protocols, experts in the field highlight the main principles and... Drug research has been greatly transformed by the "omics revolution" and advances in computational tools, combinatorial chemistry, and high through... |
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382,84 zł |
Fundamentals of Pharmaceutical Nanoscience
ISBN: 9781461491637 / Angielski / Twarda / 598 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Nanoscience or the science of the very small offers the pharmaceutical scientist a wealth of opportunities. By fabricating at the nanoscale, it is possible to exert unprecedented control on drug activity. This textbook will showcase a variety of nanosystems working from their design and construction to their application in the field of drug delivery. The book is intended for graduate students in drug delivery, physical and polymer chemistry, and applied pharmaceutical sciences courses that involve fundamental nanoscience. The purpose of the text is to present physicochemical and... Nanoscience or the science of the very small offers the pharmaceutical scientist a wealth of opportunities. By fabricating at the nanoscale, it is ... |
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382,84 zł |
Mouse Models for Drug Discovery: Methods and Protocols
ISBN: 9781607610571 / Angielski / Twarda / 436 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of techniques involving general methods as well as specific disease topics such... As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in impo... |
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382,84 zł |
Microarray Methods for Drug Discovery
ISBN: 9781607616627 / Angielski / Twarda / 285 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The postgenomic era presents a multitude of challenges for scientists in all areas of science. The information overload from new discoveries in genomics and proteomics highlight how little we really know about the functioning of a cell. The advent of Next-Generation Sequencing technologies promises to make our genetic blueprint available to the common man. The availability of the plethora of biological information has lead to the devel- ment of new areas of science and the coining of new "omics" terms including transcr- tomics, methylomics, toxicogenomics, pharmacogenomics, metabolomics,...
The postgenomic era presents a multitude of challenges for scientists in all areas of science. The information overload from new discoveries in genomi...
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382,84 zł |
Fortschritte Der Chemie Organischer Naturstoffe: Progress in the Chemistry of Organic Natural Products
ISBN: 9783211832646 / Angielski / Twarda / 188 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The condensed tannins (syn. polymeric proanthocyanidins) represent a major group of phenolic compounds in woody and some herbaceous plants (1-3). Their exceptional concentrations in the barks and heartwoods of a variety of tree species have resulted in their commercial extraction with the initial objective of applying the extracts in leather manufacture (4). Essentially all of their biological significance, e. g. the protection of plants from insects, diseases and herbivores, and most of the current, e. g. leather manufacture, and also most promising new uses, e. g. pharmaceuticals or wood...
The condensed tannins (syn. polymeric proanthocyanidins) represent a major group of phenolic compounds in woody and some herbaceous plants (1-3). Thei...
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382,84 zł |
Immunotoxicity Testing: Methods and Protocols
ISBN: 9781607614005 / Angielski / Twarda / 430 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Recent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in human risk assessment. In Immunotoxicity Testing: Methods and Protocols, expert researchers explore these changes, providing the reader with current, lab-ready procedures, along with the corresponding background information that is necessary to identify effective testing approaches for chemicals and drugs. Among the first volumes to meld consideration of immunotoxicity testing strategies with a comprehensive presentation of detailed... Recent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in ... |
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382,84 zł |
Membrane Transporters in Drug Discovery and Development: Methods and Protocols
ISBN: 9781607616993 / Angielski / Twarda / 380 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and... Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane ... |
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382,84 zł |
Cyclooxygenases: Methods and Protocols
ISBN: 9781588299536 / Angielski / Twarda / 218 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Since the discovery of the pharmacological and toxicological importance of inhibiting the cyclooxygenase (COX) enzymes by non-steroidal anti-inflammatory drugs (NSAIDs), much research has gone into the development of methods to study the biological functions of COX-1 and COX-2. In Cyclooxygenases: Methods and Protocols, experts and pioneers in the field present the most up-to-date in vitro and in vivo techniques routinely used in COX research. The volume delves into essential topics such as the purification, cloning, and expression of COX enzymes as well as in vitro assays aimed at... Since the discovery of the pharmacological and toxicological importance of inhibiting the cyclooxygenase (COX) enzymes by non-steroidal anti-inflam... |
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382,84 zł |
Systems Biology in Drug Discovery and Development: Methods and Protocols
ISBN: 9781607617990 / Angielski / Twarda / 337 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Due to the failing "one-drug-fits-all" model, it has become increasingly necessary to develop personalized medicine that treats whole systems and brings the right drug to the right patient with the right dosages. In Systems Biology in Drug Discovery and Development: Methods and Protocols, leading experts provide a practical, state-of-the-art, and holistic view of the translation of systems biology into better drug discovery and personalized medical practice. While the first part of the book describes cutting-edge technologies and methods in the field, the second part illustrates how the...
Due to the failing "one-drug-fits-all" model, it has become increasingly necessary to develop personalized medicine that treats whole systems and brin...
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382,84 zł |
Clinical Experiences with Budipine in Parkinson Therapy
ISBN: 9783540137641 / Angielski / Miękka / 213 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Some 20 years ago the introduction of levodopa opened a new era in the treatment of Parkinson's disease. Although levodopa remains the single most effective drug for the treatment of this maladie, challeng- ing therapeutic problems arise in many patients after several years of sustained treatment. Among these, fluctuations in motor performance and drug-induced involuntary movements are the most troublesome. The search for improved antiparkinsonian medications therefore con- tinues and important new developments have already occurred, for example the introduction of the dopaminergic ergots and...
Some 20 years ago the introduction of levodopa opened a new era in the treatment of Parkinson's disease. Although levodopa remains the single most eff...
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382,84 zł |