Prediction of Neuroleptic Treatment Outcome in Schizophrenia: Concepts and Methods

ISBN-13: 9783211826027 / Angielski / Miękka / 1994 / 216 str.

W. Gaebel; A. G. Awad

Opis

Prognosis is a core concept in psychiatry. This book is concerned with prediction of neuroleptic treatment outcome in schizophrenia from a conceptual and methodological point of view. Various aspects of the topic, such as definition and measurement of response, dimensions of treatment outcome, neuropsychological, neuropsychopharmacological and neurobiochemical predictors as well as the clinical application of neuroimaging methods and neurogenetics are treated by experts in the field. One aim of the book is to summarize the present state of the art in prediction research and thereby to provide a useful compendium. Moreover guidelines for future research strategies are formulated.

Spis treści

Prediction research of neuroleptic treatment outcome in schizophrenia — state of the art: 1978–1993.- Prediction research of outcome in neuroleptic treatment — definitions and concepts.- General aspects of predictor research in schizophrenia and depression.- Target dimensions in prediction of neuroleptic response: concepts and instruments.- Predictors of outcome in schizophrenia: the concept of time.- Sex differences in the prediction of neuroleptic response.- Neuroleptic-psychosocial interactions and prediction of outcome.- Pharmacokinetic aspects of neuroleptics and prediction of outcome.- Extrapyramidal side-effects and prediction of neuroleptic treatment response.- Subjective effects of neuroleptics predict compliance.- Neuropsychological prediction of treatment response and outcome in schizophrenia.- Neurochemical and neuroendocrine measures and prediction of outcome to neuroleptic therapy.- Prediction of clinical response to neuroleptics and positron emission tomography in schizophrenia..- Brain morphology and prediction of neuroleptic treatment response in schizophrenia.- Prediction of neuroleptic response: genetic strategies.- Design, methodological and statistical issues in prediction research of neuroleptic response.- Panel Discussions.- Prediction research in neuroleptic therapy — future directions.