Essential Concepts in Toxicogenomics

ISBN-13: 9781617376887 / Angielski / Miękka / 2010 / 277 str.

Donna L. Mendrick; William B. Mattes

Opis

The field of toxicogenomics is moving rapidly, so it is impossible at the timeofthiswritingtocompileaclassicmethodstextbook.Instead, wechose to identify experts in all aspects of this field and challenged them to write reviews, opinion pieces, and case studies. This book covers the main areas important to the study and use of toxicogenomics. Chapter 1 speaks to the convergenceofclassicapproachesalongsidetoxicogenomics.Chapter2deals withtheusefulnessoftoxicogenomicstoidentifythemechanismoftoxicity. Chapter3callsattentiontotheissuesthataffectthequalityoftoxicogenomics experiments, as well as the implications of using microarrays as diagnostic devices. The need for appropriate statistical approaches to genomic data is discussed in Chapter 4, and Chapters 5 and 6 describe the use of genomic datatobuildtoxicogenomicmodelsandprovideinsightsfromtheapproaches oftwocompanies.Theimportanttopicofstoringthedatageneratedinsuch experiments and the correct annotation that must accompany such data is considered in Chapter 7. The discussion in Chapter 8 speaks to the use of toxicogenomicstoidentifyspeciessimilaritiesanddifferences.Chapters9and 10dealwiththeuseofgenomicstoidentifybiomarkerswithinthepreclinical andclinicalarenas.Biomarkerswillonlybeusefulifthecommunityatlarge acceptsthemasmeaningful.Consortiaareimportanttodrivethisfunction, and Chapter11discussescurrenteffortsinthisarea.Lastbutnotleast, Chapter12 presentsaperspectiveontheregulatoryimplicationsoftoxicogenomicdataand someofthehurdlesthatcanbeseeninitsimplicationinGLPstudies.Although thisbooktendstofocusonpharmaceuticals, theissuesfacingtoxicologyare sharedbythechemicalmanufacturers, thetobaccoindustry, andtheirregulators. We want to thank our contributors for their generous time and energy in providingtheirinsights.Sadly, wemustnotetheunexpectedpassingofone ofourauthors, Dr.JosephHackettoftheFDA.Joe'scontributionservesasa testimonytohisaccomplishmentsinthisfield, andhisinsightwillbemissed intheyearstocome.

Recenzje

From the reviews:

"'Essential Concepts in Toxicogenomics' is a collections of reviews, opinion pieces and case studies written by experts in the field. ... gives good coverage of whole field of toxicogenomics. ... If you want to get up to steam with this area then ... it is certainly worth reading this book." (James Sidaway, BTS Newsletter, Winter, 2008)

Spis treści

Toxicogenomics and Classical Toxicology: How to Improve Prediction and Mechanistic Understanding of Human Toxicity Donna L. Mendrick Use of Traditional Endpoints and Gene Dysregulation to Understand Mechanisms of Toxicity: Toxicogenomics in Mechanistic Toxicology Wayne R. Buck, Jeffrey F. Waring, Eric A. Blomme. Quality Control of Microarray Assays for Toxicogenomic and In Vitro Diagnostic Applications Karol L. Thompson and Joseph Hackett Role of Statistics in Toxicogenomics Michael Elashoff Predictive Toxicogenomics in Preclinical Discovery Scott A. Barros and Rory B. Martin In Vivo Predictive Toxicogenomics Mark W Porter Bioinformatics: Databasing and Gene Annotation Lyle D. Burgoon and Timothy R. Zacharewski Microarray Probe Mapping and Annotation in Cross-Species Comparative Toxicogenomics John N Calley, William B Mattes, and Timothy Ryan Toxicogenomics in Biomarker Discovery Marc F. DeCristofaro and Kellye K. Daniels From Pharmacogenomics to Translational Biomarkers Donna L. Mendrick Public Consortium Efforts in Toxicogenomics William B. Mattes Applications of Toxicogenomics to Nonclinical Drug Development — Regulatory Science Considerations Frank D. Sistare and Joseph J. DeGeorge

Blurb

The field of toxicogenomics has been growing quickly, yet with rapid growth comes the need to periodically reflect on the nature of the field.  Essential Concepts in Toxicogenomics collects reviews, opinion pieces and case studies from the leading experts in this dynamic field with a focus on its application to pharmaceuticals.  Topics covered include issues that affect the quality of toxicogenomics experiments, statistical approaches to their data analysis, the use of such data to build toxicogenomic models, and the utilization of genomics to identify biomarkers within the preclinical and clinical arenas. Although not in the standard Methods in Molecular Biology™ series format, this volume retains the practicality and usefulness of the highly successful series.

 

Informative and cutting-edge, Essential Concepts in Toxicogenomics is an ideal resource for pharmaceutical companies, chemical manufacturers, toxicologists, and all who must keep up-to-date on progress in this vital and important field.