Many unexplored complex cellular and organismal adaptations occur in response to the stress of alcohol exposure, and its contribution to the development of chronic diseases, such as osteoporosis, heart disease and diabetes, is particularly relevant today, given the increased incidence of these diseases in our aging population. In Alcohol: Methods and Protocols, the pleiotropic effects of ethanol in animal and cell culture models are rigorously examined through a collection of detailed procedures written by experts in the field. Sections present clearly defined models of ethanol exposure,...
Many unexplored complex cellular and organismal adaptations occur in response to the stress of alcohol exposure, and its contribution to the develo...
In the decade since publication of the first edition of Crystallographic Methods and Protocols the field has seen several major developments that have both accelerated the pace of structure determination and made crystallography accessible to a broader range of investigators. Volume I, Preparation and Crystallization of Macromolecules is dedicated to the crystallization and ways to increase the odds of obtaining crystals in macromolecules, while Volume 2, Structure Determination, covers both computational methods for characterizing crystals and solving structures.
In the decade since publication of the first edition of Crystallographic Methods and Protocols the field has seen several major developments that have...
Great disparities exist between organisms with regard to the relative ease of chromosomal mutagenesis and manipulation. In Chromosomal Mutagenesis, a team of experts provide a variety of chromosomal manipulation techniques, including insertional gene disruptions, gene knockouts, stimulated homologous recombination techniques and other novel tools, for both prokaryotic and eukaryotic organisms, and attempt to expand the genetic toolbox beyond model organisms. Following the format of the highly successful Methods in Molecular Biology format, each chapter offers step-by-step laboratory...
Great disparities exist between organisms with regard to the relative ease of chromosomal mutagenesis and manipulation. In Chromosomal Mutagenesis,...
Prion Protein Protocols brings together a collection of current protocols in the field of mammalian prion disease research. Since identification of the prion protein gene some 20 years ago, what were once thought to be rare, neurodegenerative diseases of humans and animals have become a major research area. The major interest in this field results from the epidemic of bovine spongiform encephalopathy and the subsequent human prion disease, variant Creutzfeldt Jakob disease, which still poses an unknown risk to human health. The unknowns in the field stem from the enigmatic nature of...
Prion Protein Protocols brings together a collection of current protocols in the field of mammalian prion disease research. Since identification of th...
Drug delivery systems (DDS) are an important component of drug development and therapeutics. The field is quite extensive and requires an encyclopedia to describe all the technologies. The aim of this book is to put together descriptions of important selective technologies used in DDS. Important drugs, new technologies such as nanoparticles, as well as important therapeutic applications, are taken into consideration in this selection. This book will be an important source of information for pharmaceutical scientists and pharmacologists working in the academia as well as in the industry. It...
Drug delivery systems (DDS) are an important component of drug development and therapeutics. The field is quite extensive and requires an encyclopedia...
Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In Pharmacogenomics in Drug Discovery and Development, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. Divided into three sections, the volume begins by exploring cutting-edge technologies used to pursue...
Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field pharmacogenomics arose t...
At the time of the lightbulb's invention, not even the most imaginative thinkers could have predicted the prevention and treatment of disease through genes delivered by electric fields. In Electroporation Protocols: Preclinicaland Clinical Gene Medicine, top researchers provide hands-on protocols describing the process of non-viral delivery of genetic materials such as DNA, oligo-DNA, and RNA into targeted immune cells, tissues, and model animals in order to better treat disease. Following the successful Methods in Molecular Biology(TM) series format, each method and protocol...
At the time of the lightbulb's invention, not even the most imaginative thinkers could have predicted the prevention and treatment of disease throu...
Since the first edition, published in 2001, genomics research has taken great strides. In this updated second edition, a team of expert researchers share the most current information in a field that has recently switched emphasis from gene identification to functional genomics and the characterization of genes and gene products. This volume approaches its subject with a broad perspective to supply its reader with a vital overview of genomics and its derivative fields.
Since the first edition, published in 2001, genomics research has taken great strides. In this updated second edition, a team of expert researchers...
In 2003, the word coronavirus spread across the globe, somewhat further than the virus that sparked the panic. In SARS- and Other Coronaviruses: Laboratory Protocols, expert researchers examine these devastating viruses through detailed laboratory protocols. Chapters deal with such subjects as detection and discovery of coronaviruses by nucleic acid and antibody-based approaches, virus isolation, propagation and titration, virus purification, structure analysis by electron cryomicroscopy, expression and crystallization of viral proteins, raising antibodies against viral proteins,...
In 2003, the word coronavirus spread across the globe, somewhat further than the virus that sparked the panic. In SARS- and Other Coronaviruses: La...
Molecular modeling has undergone a remarkable transformation in the last 20 years. This book provides thorough introductions and a compilation of step-by-step methods applicable to problems faced by non-specialists especially those new to the software packages used in molecular modeling. Tips on troubleshooting and avoiding common pitfalls are included in the book, along with chapters covering a wide range of subjects. Links to downloadable software are also provided."
Molecular modeling has undergone a remarkable transformation in the last 20 years. This book provides thorough introductions and a compilation of s...
