All blood-contacting medical devices in use today are subjected to some degree poorer blood compatibility than the native artery. Hemostatic mechanism, arresting bleeding from injured blood vessels, induces platelet adhesion and activation onto artificial biomaterials, which leads to undesirable outcomes such as blood clotting at the site of the implant, continual shedding of thrombi, and depletion of platelets from the blood stream. Such complications have hampered the clinical success of blood contacting devices, limiting the patent of small-diameter vascular grafts and making necessary the...
All blood-contacting medical devices in use today are subjected to some degree poorer blood compatibility than the native artery. Hemostatic mechanism...