The resistance to anticancer drugs (cytotoxic compounds and molecular targeted agents) and radiotherapy is the main obstacle for an effective treatment of human cancers. This limitation to the success of cancer treatment has led to the study of the molecular mechanisms underling drug resistance as well as to the development of novel combinatorial strategies which can overcome the acquired and intrinsic resistance. In this book by presenting novel mechanisms of drug resistance two different lines of research are analyzed: a) The molecular basis of resistance to the treatment with the novel...
The resistance to anticancer drugs (cytotoxic compounds and molecular targeted agents) and radiotherapy is the main obstacle for an effective treatmen...