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Lipid Second Messengers
ISBN: 9780849333835 / Angielski / Miękka / 160 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A detailed methodology for analysis of various lipid signalling pathways. Authoritative contributors explain the factors that regulate lipid second messenger production by agonist-activated enzymes and examine their products. Topics discussed include procedures used to measure lipid-derived mediators such as lysophospholipids, arachidonic acid, eicosanoids, anandamide and ceramides, and the enzymes responsible for generating these messengers, such as phospholipases, prostaglandin endoperoxide synthases and sphingomyelinase.
A detailed methodology for analysis of various lipid signalling pathways. Authoritative contributors explain the factors that regulate lipid second me...
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cena:
558,65 |
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Element Analysis of Biological Samples: Principles and Practice
ISBN: 9780849354243 / Angielski / Twarda / 272 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Despite the development of innovative new analytical techniques for biological trace element research, today's trace element investigators face formidable obstacles to obtaining reliable data. This complete reference identifies and assesses the challenges the analyst encounters at each stage of an analysis, and discusses the effects of various techniques on the sample.
Three internationally recognized scientists and authors consider the effects of the numerous collection, storage, and sample preparatory techniques used in sample analysis. Proper analytical quality control, including such... Despite the development of innovative new analytical techniques for biological trace element research, today's trace element investigators face formid...
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cena:
1214,46 |
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Analysis of Carbohydrates by GLC and MS
ISBN: 9780849368516 / Angielski / Twarda / 304 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A comprehensive guide to analysis of carbohy-drates by gas-liquid chromatography and mass spectrometry. Explaining the facets of carbohydrate analysis and their relation to each other, it also contains reference in-formation useful to practitioners in the field. It highlights improvements in car-bohydrate analyses methodology.
A comprehensive guide to analysis of carbohy-drates by gas-liquid chromatography and mass spectrometry. Explaining the facets of carbohydrate analysis...
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cena:
2671,81 |
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Proteins of Iron Metabolism
ISBN: 9780849386763 / Angielski / Twarda / 608 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The comprehensive coverage of the advances in understanding the mechan isms controlling cellular iron metabolism, especially at the molecular level, found in this book will give you insight into the regulation o f iron metabolism. Proteins of Iron Metabolism fills the need for a cl early written, comprehensive review of the latest research, putting ev ery thing you need in one easy-to-use resource.
The comprehensive coverage of the advances in understanding the mechan isms controlling cellular iron metabolism, especially at the molecular level, f...
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cena:
922,99 |
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Cyclic Nucleotide Phosphodiesterases in Health and Disease
ISBN: 9780849396687 / Angielski / Twarda / 728 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research.
Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms. It examines phosphodiesterases as pharmacological targets as well as the development of specific PDE inhibitors as therapeutic agents.... Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progre...
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cena:
1263,03 |
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Glycoanalysis Protocols
ISBN: 9780896033559 / Angielski / Twarda / 262 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Protein glycosylation is now acknowledged as a major posttranslational modification with significant effects on protein folding, conformation distri- bution, stability, and activity. The added oligosaccharide chains are large and diverse and have specific recognition motifs important in many aspects of cell interactions and regulation. As such, there is a growing need to communicate the analytical methods of the specialist carbohydrate chemist, biochemist, and physicochemist to protein experts and the pharmaceutical industry. Other areas that come under the influence of the glycosciences are...
Protein glycosylation is now acknowledged as a major posttranslational modification with significant effects on protein folding, conformation distri- ...
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cena:
402,53 |
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G Proteins, Receptors, and Disease
ISBN: 9780896034303 / Angielski / Twarda / 324 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. "Theoretically, one should obtain essentially the same clinical picture from failure of an end-organ to respond to a hormone as from a decreased production or absence of said hormone. " With these words, Fuller Albright began his now classic paper describing a novel disease, pseudo hypoparathyroidism (PHP), and a novel concept, hormone resis tance as a cause of disease. Soon, other hormone resistance disorders such as nephrogenic diabetes insipidus (NDI) were recognized, and the concept was extended to resistance to other substances such as calcium ions in familial hypocalciuric hypercalcemia...
"Theoretically, one should obtain essentially the same clinical picture from failure of an end-organ to respond to a hormone as from a decreased produ...
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cena:
805,10 |
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Endothelin: Molecular Biology, Physiology, and Pathology
ISBN: 9780896034365 / Angielski / Twarda / 274 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A unique, integrated collection of original contributions on the molecular biology, physiology, and pathology of endothelin. Leading academic, clinical, and industrial researchers summarize the dramatic recent progress in endothelin research and indicate the optimal direction of future studies. The contributors produce a critical evaluation of endothelin chemistry and pharmacology, its mechanism of action, and its physiological functions. The book is certain to become the new standard reference source for both basic scientists and informed clinicians who want a clear idea of the roles...
A unique, integrated collection of original contributions on the molecular biology, physiology, and pathology of endothelin. Leading academic, clinica...
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cena:
603,81 |
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Phospholipid Signaling Protocols
ISBN: 9780896034914 / Angielski / Twarda / 380 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Cell membranes are not, as once believed, inert structures designed to contain the cell contents, but are in fact dynamic structures that are as me- bolically active as the cytosol and other cellular compartments they surround. Thus membranes not only contain mixtures of lipid and phospholipids, but also many proteins both embedded deeply within the membrane structure itself and also more loosely attached on the membrane surfaces. Though many such proteins have long been known to act as transport proteins, ion channels, hormone receptors, G proteins, cytoskeletal anchorage points, and so on,...
Cell membranes are not, as once believed, inert structures designed to contain the cell contents, but are in fact dynamic structures that are as me- b...
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cena:
402,53 |
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Aging Methods and Protocols
ISBN: 9780896035829 / Angielski / Twarda / 385 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Aging is an almost universal process within biological systems, one which leads to a decline in functional capacity, disease onset, and eventually death. There has been much interest in recent years to elucidate the molecular mec- nisms that underlie the aging process. Many theories have been proposed since the last century that aim to explain the causes of aging. There is no one theory that completely satisfies the phenotype of aging, but genetics and environm- tal factors play an important role in the etiology of age-related pathologies and the aging process. However, there is still much to...
Aging is an almost universal process within biological systems, one which leads to a decline in functional capacity, disease onset, and eventually dea...
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cena:
402,53 |
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PCR Protocols
ISBN: 9780896036277 / Angielski / Miękka / 556 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Drawing on the highly successful first edition, this newly-revised second edition covers the many advances made in PCR technology since the first book, which has been used in more than 10,000 laboratories worldwide. As PCR technology has advanced significantly since the first edition, and has expanded its use in the clinical laboratory of physician/researchers, the scope of this book is greatly expanded to enable researchers at all levels to easily reproduce and adapt PCR experiments to their own specific requirements. The meethods selected represent worked examples from many fields that can...
Drawing on the highly successful first edition, this newly-revised second edition covers the many advances made in PCR technology since the first book...
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cena:
402,53 |
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Calpain Methods and Protocols
ISBN: 9780896036321 / Angielski / Twarda / 342 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The purpose of Calpain Methods and Protocols is quite straightf- ward: it is to present the actual experimental methods used in many different laboratories for the study of calpain. It will provide the vital experimental detail, and the discussion of possible pitfalls, for which the standard journals no longer provide space. This will make it as easy as possible for investi- tors interested in calpain to adopt established methods without repeating old mistakes, and to adapt and apply these methods in novel approaches to the many outstanding calpain questions. These questions range from purely...
The purpose of Calpain Methods and Protocols is quite straightf- ward: it is to present the actual experimental methods used in many different laborat...
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cena:
402,53 |
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DNA Repair Protocols: Prokaryotic Systems
ISBN: 9780896036437 / Angielski / Twarda / 192 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. When setting out to decide on the content of DNA Repair Protocols: Prokaryotic Systems, I was conscious of the need to portray the vast array of pathways and enzymatic activities that are part of the discipline of DNA repair. In addition to the classical DNA repair activities, I wanted to convey the significant interest that has been generated in recent years in the use of the proteins and repair systems as research tools, much like the use of restriction enzymes over the last few decades. Therefore, in addition to chapters deta- ing protocols for investigating specific repair activities, I...
When setting out to decide on the content of DNA Repair Protocols: Prokaryotic Systems, I was conscious of the need to portray the vast array of pathw...
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cena:
402,53 |
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Amino Acid Analysis Protocols
ISBN: 9780896036567 / Angielski / Twarda / 265 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Amino acid analysis is a technique that has become commonplace in biotechnology, biomedical, and food analysis laboratories. This book describes a variety of amino acid analysis techniques and how each technique can be used to answer specific biological questions. The first two chapters in Amino Acid Analysis Protocols introduce the concepts, basic theory, and practice of amino acid analysis. The following chapters give detailed instructions on various methods and their applications. As highlighted, there are many different approaches to amino acid ana- sis, but in all cases the results...
Amino acid analysis is a technique that has become commonplace in biotechnology, biomedical, and food analysis laboratories. This book describes a var...
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cena:
402,53 |
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Nuclease Methods and Protocols
ISBN: 9780896036796 / Angielski / Twarda / 525 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Nucleases, enzymes that restructure or degrade nucleic acid polymers, are vital to the control of every area of metabolism. They range from housekeeping enzymes with broad substrate ranges to extremely specific tools (1). Many types of nucleases are used in lab protocols, and their commercial and clinical uses are expanding. The purpose of Nuclease Methods and Protocols is to introduce the reader to some we- characterized protein nucleases, and the methods used to determine their activity, structure, interaction with other molecules, and physiological role. Each chapter begins with a...
Nucleases, enzymes that restructure or degrade nucleic acid polymers, are vital to the control of every area of metabolism. They range from housekeepi...
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cena:
603,81 |
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Protein Kinase Protocols
ISBN: 9780896037007 / Angielski / Twarda / 365 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The wealth of primary information provided by genome sequencing projects in various species is of enormous potential value in our efforts to understand biological funtions and molecular interactions not only in normal development and cellular physiology, but also in diseases. However, utili- tion of these resources can come only from the development and application of a fully integrated set of molecular, biochemical, biophysical, and genetic skill bases. As key components of many cell signalling pathways, protein kinases are implicated in a broad variety of diseases, including cancers and...
The wealth of primary information provided by genome sequencing projects in various species is of enormous potential value in our efforts to understan...
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cena:
402,53 |
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Angiotensin Protocols
ISBN: 9780896037632 / Angielski / Twarda / 530 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A qualitative leap in the understanding of cardiovascular and n- ral regulation by the renin angiotensin system, and of the role of this s- tem in tissue damage, has occurred as a result of the many recent advances in molecular genetic techniques. The cloning of the genes for the components of the renin angiotensin system, the design of specific angiotensin receptor ligands, and the use of embryonic gene targeting te- niques for the creation of mutant strains have established that the renin angiotensin system is important in blood pressure regulation, ion and fluid homeostasis, and tissue...
A qualitative leap in the understanding of cardiovascular and n- ral regulation by the renin angiotensin system, and of the role of this s- tem in tis...
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cena:
603,81 |
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Capillary Electrophoresis of Nucleic Acids
ISBN: 9780896037656 / Angielski / Twarda / 408 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The development of PCR, which enables extremely small amounts of DNA to be amplified, led to the rapid development of a multiplicity of a- lytical procedures to utilize this new resource for analysis of genetic variation and for the detection of disease causing mutations. The advent of capillary electrophoresis (CE), with its power to separate and analyze very small amounts of DNA, has also stimulated researchers to develop analytical procedures for the CE format. The advantages of CE in terms of speed and reproducibility of analysis are manifold. Further, the high sensitivity of detection,...
The development of PCR, which enables extremely small amounts of DNA to be amplified, led to the rapid development of a multiplicity of a- lytical pro...
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cena:
402,53 |
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Capillary Electrophoresis of Nucleic Acids
ISBN: 9780896037793 / Angielski / Twarda / 484 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The development of PCR, which enables extremely small amounts of DNA to be amplified, led to the rapid development of a multiplicity of a- lytical procedures that permit use of this new resource for the analysis of genetic variation and for the detection of disease-causing mutations. The advent of capillary electrophoresis (CE), with its power to separate and a- lyze very small amounts of DNA, has also stimulated researchers to develop analytical procedures for the CE format. The advantages of CE in terms of speed and reproducibility of analyses are manifold. Furthermore, the high s- sitivity...
The development of PCR, which enables extremely small amounts of DNA to be amplified, led to the rapid development of a multiplicity of a- lytical pro...
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cena:
603,81 |
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Oxidative Stress Biomarkers and Antioxidant Protocols
ISBN: 9780896038509 / Angielski / Twarda / 322 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The first protocols book, Free Radical and Antioxidant Protocols (1) was published in late 1998. Sections were divided into three parts, covering selected biochemical techniques for measuring oxidative stress, antioxidant (AOX) activity, and combined applications. In choosing the 40 methods to be included in that book, I realized there were considerably more of equal value than that which we could have presented in a single volume. To produce a comprehensive resource, this book and a third are being compiled to expand coverage of the field. A summary of papers (2) published on this important...
The first protocols book, Free Radical and Antioxidant Protocols (1) was published in late 1998. Sections were divided into three parts, covering sele...
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cena:
402,53 |
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