Endothelin: Molecular Biology, Physiology, and Pathology

ISBN-13: 9780896034365 / Angielski / Twarda / 1997 / 274 str.

Robert F. Highsmith

Opis

A unique, integrated collection of original contributions on the molecular biology, physiology, and pathology of endothelin. Leading academic, clinical, and industrial researchers summarize the dramatic recent progress in endothelin research and indicate the optimal direction of future studies. The contributors produce a critical evaluation of endothelin chemistry and pharmacology, its mechanism of action, and its physiological functions. The book is certain to become the new standard reference source for both basic scientists and informed clinicians who want a clear idea of the roles endothelin may play in cardiovascular physiology and pathology.

Recenzje

"The book is well structured, with the subjects dealt with in a logical and well-defined manneer...Each of the chapters are well referenced, thus providing a good starting point for those who wish to delve deeper into the field." - Cell Biology International

Spis treści

Endothelin Receptor Subtypes and Tissue Distribution, D. M. Pollock. Molecular Biology of the Endothelin Receptors, J. A. Lee, E. H. Ohlstein, C. E. Peishoff, and J. D. Elliott. Molecular Biology of Endothelin-Converting Enzyme (ECE), R. Takayanagi, K. Ohnaka, W. Liu, T. Ito, and H. Nawata. Endothelin Receptor-Signaling Mechanisms in Vascular Smooth Muscle, E. R. Decker and T. A. Brock. Mechanisms of Endothelin-Induced Mitogenesis in Vascular Smooth Muscle, T. Force. The Renal and Systemic Hemodynamic Actions of Endothelin, R. O. Banks, D. M. Pollock, and J. Novak. The Development of Specific Endothelin-Receptor Antagonists, T. D. Warner. Pathophysiological Role of Endothelin and Potential Therapeutic Targets for Receptor Antagonists, D. P. Brooks, D. K. Jorkasky, M. I. Freed, and E. H. Ohlstein. Index.

Blurb

In Endothelin: Molecular Biology, Physiology, and Pathology, academic, clinical, and industrial researchers summarize the dramatic recent progress that has been documented in endothelin research and indicate the optimal direction of future studies. The contributors, highly respected authorities in their fields as well as active bench scientists, produce a critical evaluation and synthesis of our knowledge of endothelin chemistry and pharmacology, its mechanism of action, and its physiological functions.

Endothelin: Molecular Biology, Physiology, and Pathology is certain to become the new standard reference source for both basic scientists and informed clinicians who want a clear idea of the roles endothelin may play in cardiovascular physiology and pathology. Biochemists, as well as medicinal and clinical chemists, involved in the development of drugs designed to alter the action or expression of the endothelin molecule will find the book rich in new results and insights.

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