Kategoria BISAC: Science >> Life Sciences - Cell Biology

The bacterial cell wall represents a very complex structure disconnecting the interior of single-cell organisms from the environment, thus protecting, but also enabling, them to interact with the surrounding milieu and to exchange both substances and information. Knowledge of the biochemistry of the cell wall (components) and the genetic background helps to understand their significance with regard to microbiology and immunology of bacteria. This book represents the second edition of a publication which was presented nearly 20 years ago in the German language (Die bakterielle Zellwand). Since...

In 1970, Manfred Eigen initiated the study of the origin of self-reproducing systems of macromolecules and their evolution. Large-scale nucleotide sequencing (with computer methods) was introduced from 1977. The authors of this book, the first edition of which appeared (in Russian) in 1985, have been engaged in the research of the evolution of molecular genetic regulatory systems ever since those pioneering years. The book considers many fundamental problems of molecular biology, evolution, molecular genetic organization, the structure and function of macromolecules, always with the...

During their lifetime, especially when growing and dividing, cells go through various steps of the cell cycle. Knowledge of the individual steps of the cell cycle will help us understand the development of a variety of diseases better, including cancer, and also to design new drugs against it. New techniques for studying the molecular basis of these processes have recently been developed and are described in detail in this manual.
A glossary helps the reader to cope with the complex cell cycle terminology.

The studies described here were carried out in the Neuroregulation Group at the Department of Physiology of the University of Leiden. Over the last decade this group has, in close collaboration with the departments of neurosurgery and urology of the Academic Hospital of Leiden, studied development and regeneration of the spinal cord and its peripheral nerves both from a neuroanatomical and a clinical perspective. During this period the development of brainstem projections to the spinal cord of the rat was studied with a retrograde tracing technique. Horseradish peroxidase was injected into...

The problem of the long-term proliferation of cells is a seminal one. It has always been a hot subject in biology, a source of far-reaching hypotheses, even more so now when explanations for the mechanisms of cell prolifera tive mortality or immortality seem within our reach. A question which is still debated is whether an infinite division potential can be a normal trait or is always the result of modifications leading to abnormal cell growth and escape from homeostasis. In general, investigators have been advocates of one of the two extremes, universal limited or unlim ited normal...

Flow cytometric analysis of molecular, biochemical, genetic and developmental parameters using cellular fluorescence techniques as well as fluorescence-activated (FACS) or magnetic (MACS) cell sorting technologies provide unique options for molecular and cellular biology. In recent years, these technologies have been considerably advanced.
In this second edition, all chapters have been updated according to the recent improvements and modifications. Further, new protocols have been added, such as on magnetic selection, magnetofluorescent liposomes, the cytometry of secreted products and...

Actin is one of the most widespread proteins in eukaryotic cells. This book and its companion ("Molecular Interactions of Actin. Actin Structure and Actin-Binding Proteins") provide an authoritative and opinionated view of the structure and function of this essential protein. Each section includes an historical perspective and a detailed commentary on actin protein chemistry, molecular and cell biology of actin. While some chapters review the body of knowledge of the subject, others contain new experimental data.
This book will appeal to research scientists seeking contemporary overviews...

Cell biologists have recently come to understand that asymmetry of division is an important regulatory phenomenon in the fate of a cell. In adult organisms asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to aging. This book describes the phenomenon in different organisms and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.

This work offers a fascinating insight into a crucial genetic process. Recombination is, quite simply, one of the most important topics in contemporary biology. This book is a totally comprehensive treatment of the subject, summarizing all existing views on the topic and at the same time putting them into context. It provides in-depth and up-to-date analysis of the chapter topics, and has been written by international experts in the field.

Imaging Cellular and Molecular Biological Function provides a unique selection of essays by leading experts, aiming at scientist and student alike who are interested in all aspects of modern imaging, from its application and up-scaling to its development. The chapter content ranges from the basic through to complex overview of method and protocols, and there is also practical and detailed how-to content on important, but rarely addressed topics. This first edition features all-colour-plate chapters.

The philosophy of this volume is to provide student, researcher, PI, professional...

Brings together international research on the subject of programmed cell death, and covers such areas as the biochemical mechanisms, introduction of DNA fragmentation, enetic regulation, and the importance of apoptosis in the immune system, particularly during T-cell development, and in cancer.

The technique of needle microinjection has become a prominent experime ntal approach in biological research. Cellular organelles, DNA and RNA, enzymes, structural proteins, metabolites, ions and antibodies are j ust some of the molecular and cellular elements that have been transpo sed from test tubes into living cells by needle injection. This techni que is broadly used as a valuable tool for the study of many different cell responses in a variety of systems. From individual cell signalin g responses, such as regulation of metabolic pathways and second funct ion of second messengers, the...

Glycoproteins play an important role in the regulation of gene expression, cell growth, migration, differentiation and apoptosis. Over the last decade, research has highlighted the therapeutic implications of glycoproteins for many physiological and pathological processes, such as inflammation, arthritis and metastasis. The first part of the book deals with the structure and biosynthesis of glycoconjugates; the second part addresses the pathological roles played by glycoconjugates and their potential therapeutic applications.

This book contains papers which discuss many different stimulus--response systems ranging from those in bacteria and paramecia to those in insects and mammals. Emphasis is placed on the identification and characterization of receptor molecules, physical properties of channel molecules, physical and chemical changes in receptors, channels and other structures after stimuli, and the molecular events in the sequential response, excitation, adaptation and learning phases. Use is made throughout of both traditional and new techniques in electrophysiology, biochemistry, genetics and ultrastructural...

Molecular biology and genetics are fast-growing fields. Genetic engineering and biotechnological innovations have also restructured our views of the field. Raw data from the wet lab are accumulated at an ever increasing rate since the beginning of the large-scale sequencing of genomes of model organisms and the human. The necessary involvement of scientists of widely-divergent backgrounds to analyze the data has been evident, and computers are intimately tied into the analysis of biological data. This volume is a collection of computer and mathematical treatments of current challenges of...

Revolutionary and original, this treatise presents a new paradigm of Emergence and Complexity, with applications drawn from numerous disciplines, including artificial life, biology, chemistry, computation, physics, image processing, information science, etc.

CNN is an acronym for Cellular Neural Networks when used in the context of brain science, or Cellular Nonlinear Networks, when used in the context of emergence and complexity. A CNN is modeled by cells and interactions: cells are defined as dynamical systems and interactions are defined via coupling laws. The CNN paradigm is a universal...

- Brings together state-of-the information on stem cells
- Comprehensive coverage of all aspects of stem cells
- Contributions by renowned scientists in specific fields
- Extensive self-explanatory figures, color photos, graphics.

Cell mechanics is the field of study that looks at how cells detect, modify, and respond to the physical properties of the cell environment. Cells communicate with each other through chemical and physical signals which are involved in a range of process from embryogenesis and wound healing to pathological conditions such as cancerous invasion. Similar principles are also likely to be critical for success in regenerative medicine. Cell mechanics is thus central to understanding these principles. As cell mechanics draws from the fields of biology, chemistry, physics, engineering, and...

Microalgae have been largely cultured and commercialized as food and feed

additives, and their potential as source of high-added value compounds is well known.

But, in contrast to the large number of genetically modified bacteria, yeast and even

higher plants, only a few species of microalgae have been genetically transformed

with efficiency. Initial difficulties in the expression of foreign genes in microalgae

have been progressively overcome, and powerful molecular tools for their genetic

engineering are now on hand. A considerable collection of...