The last 15 years in development of biology were marked with accumulation of unprecedentedly huge arrays of experimental data. The information was amassed with exclusively high rates due to the advent of highly efficient experimental technologies that provided for high throughput genomic sequencing; of functional genomics technologies allowing investigation of expression dynamics of large groups of genes using expression DNA chips; of proteomics methods giving the possibility to analyze protein compositions of cells, tissues, and organs, assess the dynamics of the cell proteome, and...

Bioinformatics of Genome Regulation and Structure covers:

-regulatory genomic sequences: databases, knowledge bases, computer analysis, modeling, and recognition;
-large-scale genome analysis and functional annotation;
-gene structure detection and prediction;
-comparative and evolutionary genomics;
-computer analysis of genome polymorphism and evolution; computer analysis and modeling of transcription, splicing, and translation; structural computational biology: structure-function organization of genomic DNA, RNA, and proteins;
-gene networks,...

In 1970, Manfred Eigen initiated the study of the origin of self-reproducing systems of macromolecules and their evolution. Large-scale nucleotide sequencing (with computer methods) was introduced from 1977. The authors of this book, the first edition of which appeared (in Russian) in 1985, have been engaged in the research of the evolution of molecular genetic regulatory systems ever since those pioneering years. The book considers many fundamental problems of molecular biology, evolution, molecular genetic organization, the structure and function of macromolecules, always with the...

Modern natural science shows that the infancy of life on Earth experienced prebiotic evolution and included the emergence of primitive self-reproducing biologic forms and their systems. The subsequent coevolution of inorganic environment and biologic systems resulted in global propagation of life over the Earth and its enormous diversification. Diverse living organisms colonized the land, water, and atmosphere, as well as upper layers of the lithosphere, thereby forming the biosphere. Formerly, it was thought that abiogenic synthesis of prebiotic matter occurred in the Earth s atmosphere on...

In 1970, Manfred Eigen initiated the study of the origin of self-reproducing systems of macromolecules and their evolution. Large-scale nucleotide sequencing (with computer methods) was introduced from 1977. The authors of this book, the first edition of which appeared (in Russian) in 1985, have been engaged in the research of the evolution of molecular genetic regulatory systems ever since those pioneering years. The book considers many fundamental problems of molecular biology, evolution, molecular genetic organization, the structure and function of macromolecules, always with the...

Modern natural science shows that the infancy of life on Earth experienced prebiotic evolution and included the emergence of primitive self-reproducing biologic forms and their systems. The subsequent coevolution of inorganic environment and biologic systems resulted in global propagation of life over the Earth and its enormous diversification. Diverse living organisms colonized the land, water, and atmosphere, as well as upper layers of the lithosphere, thereby forming the biosphere. Formerly, it was thought that abiogenic synthesis of prebiotic matter occurred in the Earth s atmosphere on...

- The data gathered can be used to solve a wide range of problems - for basic science and applied science