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Computational Modeling of Biological Systems: From Molecules to Pathways
ISBN: 9781461421450 / Angielski / Twarda / 366 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Computational modeling is emerging as a powerful new approach to study and manipulate biological systems. Multiple methods have been developed to model, visualize, and rationally alter systems at various length scales, starting from molecular modeling and design at atomic resolution to cellular pathways modeling and analysis. Higher time and length scale processes, such as molecular evolution, have also greatly benefited from new breeds of computational approaches. This book provides an overview of the established computational methods used for modeling biologically and medically relevant...
Computational modeling is emerging as a powerful new approach to study and manipulate biological systems. Multiple methods have been developed to mode...
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cena:
402,53 |
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Molecular Theory of the Living Cell: Concepts, Molecular Mechanisms, and Biomedical Applications
ISBN: 9781461421511 / Angielski / Twarda / 748 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The book presents the first comprehensive molecular theory of the living cell ever published since the cell doctrine was formulated in 1838-1839. It introduces into cell biology over three dozens of key concepts, principles and laws imported from physics, chemistry, computer science, linguistics, semiotics and philosophy. The author formulates physically, chemically and enzymologically realistic molecular mechanisms to account for basic living processes such as ligand-receptor interactions, enzymic catalysis, force-generating mechanisms in molecular motors, chromatin remodelling, and... The book presents the first comprehensive molecular theory of the living cell ever published since the cell doctrine was formulated in 1838-1839. I... |
cena:
805,10 |
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Biocomputing and biochemical studies of enzymes
ISBN: 9783639185904 / Angielski / Miękka / 204 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The human kallikrein family is a family of proteolytic enzymes, classified as serine proteases, that derive from chromosome 19, locus 13.3-13.4. One member of the family, human kallikrein 4 (hK4) which is thought to carry out crucial functions in the prostate, was expressed in this study as a secreted protein in a baculovirus expression system, bearing a His-tag and V5-epitope that were used for purification and detection respectively. Computational analysis was included by applying high-performing computing techniques, such as molecular dynamics, and flexible ligand docking, to predict...
The human kallikrein family is a family of proteolytic enzymes, classified as serine proteases, that derive from chromosome 19, locus 13.3-13.4. One ...
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cena:
353,37 |
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Transport Phenomena in Intervertebral Disc
ISBN: 9783639245042 / Angielski / Miękka / 216 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Low back pain represents a significant concern in the United States, with 70% of individuals experiencing symptoms at some point in their lifetime. Symptoms of low back pain have been strongly associated with degeneration of the intervertebral disc. Insufficient nutritional supply is believed to be a major mechanism for disc degeneration. Thus, understanding nutrients transport in intervertebral disc is crucial to elucidate the etiology of disc degeneration, and to develop strategies for tissue repair, and tissue engineering. Transport phenomena in intervertebral disc are still...
Low back pain represents a significant concern in the United States, with 70% of individuals experiencing symptoms at some point in their lifetime....
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cena:
353,37 |
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A Theory of Calcium Dynamics in Paralyzed Human Soleus
ISBN: 9783639314601 / Angielski / Miękka / 348 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In current models of muscle force and fatigue in denervated subjects, the mechanistic understanding of the role of baseline calcium current (R0) and the voltage sensitivity (km) is inadequate. R0 and km are assumed to be scalar, which generates errors in predicting force and fatigue respectively in response to external electrical stimulation. Previous work generated experimental data that conform to the Riccati/logistic/Boltzmann equation. To extend that work, a theoretical analysis of the role of calcium current, assumed to be a Riccati-Bass growth/diffusion/decay process, is presented for...
In current models of muscle force and fatigue in denervated subjects, the mechanistic understanding of the role of baseline calcium current (R0) and t...
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cena:
353,37 |
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Liposomes Loaded with Topotecan and Vincristine for Cancer Treatment
ISBN: 9783639378504 / Angielski / Miękka / 136 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Remote loading of liposomes by transmembrane gradients is one of the best approaches for achieving the high drug level per liposome. This breakthrough, which enabled the clinical use of nanoliposomal drugs, has not been paralleled by good understanding that allows predicting loading efficiency of drugs. We developed a model that relates drug physicochemical properties and loading conditions to loading efficiency. This model enables choosing candidate molecules for remote loading and optimizing loading conditions according to logical considerations. In order to improve the therapeutic...
Remote loading of liposomes by transmembrane gradients is one of the best approaches for achieving the high drug level per liposome. This breakthro...
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cena:
263,91 |
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Bayesian Methods in Structural Bioinformatics
ISBN: 9783642272240 / Angielski / Twarda / 386 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This volume is a high-profile overview of the current state of play in statistical methods applied to structural bioinformatics. With almost 100 pages of introductory material, it covers topics including protein structure prediction and simulation.
This volume is a high-profile overview of the current state of play in statistical methods applied to structural bioinformatics. With almost 100 pages...
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cena:
402,53 |
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Optical Coherence Tomography: A Clinical and Technical Update
ISBN: 9783642274091 / Angielski / Twarda / 255 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Optical Coherence Tomography represents the ultimate noninvasive ocular imaging technique although being in the field for over two-decades. This book encompasses both medical and technical developments and recent achievements. Here, the authors cover the field of application from the anterior to the posterior ocular segments (Part I) and present a comprehensive review on the development of OCT. Important developments towards clinical applications are covered in Part II, ranging from the adaptive optics to the integration on a slit-lamp, and passing through new structural and functional...
Optical Coherence Tomography represents the ultimate noninvasive ocular imaging technique although being in the field for over two-decades. This book ...
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cena:
402,53 |
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Store-Operated Ca2+ Entry (Soce) Pathways: Emerging Signaling Concepts in Human (Patho)Physiology
ISBN: 9783709109618 / Angielski / Twarda / 482 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book thoroughly explores robotics in neurorehabilitative therapy, describing state-of-the-art applications of robotic devices for locomotion; posture and balance and upper extremity recovery in stroke. Includes schematic diagrams, photographs and tables.
This book thoroughly explores robotics in neurorehabilitative therapy, describing state-of-the-art applications of robotic devices for locomotion; pos...
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cena:
603,81 |
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Radiation Damage in Biomolecular Systems
ISBN: 9789400725638 / Angielski / Twarda / 510 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Since the discovery of X-rays and radioactivity, ionizing radiations have been widely applied in medicine both for diagnostic and therapeutic purposes. The risks associated with radiation exposure and handling led to the parallel development of the field of radiation protection. Since the discovery of X-rays and radioactivity, ionizing radiations have been widely applied in medicine both for diagnostic and therapeutic purpo... |
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603,81 |
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Embryogenesis Explained
ISBN: 9789814350488 / Angielski / Twarda / 784 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The greatest mystery of life is how a single fertilized egg develops into a fully functioning, sometimes conscious multicellular organism. Embryogenesis Explained offers a new theory of how embryos build themselves, and combines simple physics with the most recent biochemical and genetic breakthroughs, based on the authors' prediction and then discovery of differentiation waves. They explain their ideas in a form accessible to the lay person and a broad spectrum of scientists and engineers. The diverse subjects of development, genetics and evolution, and their physics, are brought together to...
The greatest mystery of life is how a single fertilized egg develops into a fully functioning, sometimes conscious multicellular organism. Embryogenes...
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cena:
1224,44 |
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Nature's Silent Music
ISBN: 9780911311334 / Angielski / Miękka / 246 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In this book, scientist Philip Callahan shows how "civilized" insanity is turning Ireland away from her naturally harmonious, aesthetically pleasing, sound practices. Why remove a thatched roof to replace it with galvanized tin, only to increase the heating bill? With insightful wisdom, Callahan also examines the mysterious power of round towers, "magic spots," and healers such as Biddy Early. Callahan's study of hedgerows, booley people and Ireland's traditional form of agriculture can teach everyone the value of the land and why not to carelessly destroy it with toxic chemicals.
In this book, scientist Philip Callahan shows how "civilized" insanity is turning Ireland away from her naturally harmonious, aesthetically pleasing, ...
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cena:
86,32 |
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Band 3 Diffusion in Rbc and Implications for Rbc Membrane Structure
ISBN: 9783838353074 / Angielski / Miękka / 176 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Band 3 which is the one of the most abundant membrane protein in red blood cell membrane. It is bound to the spectrin network via other proteins such as ankyrin, 4.1 or junctional complex. In addition to that literature suggests the presence of different sub populations of band 3. The spectrin mesh leads to the hexagonal compartments in red blood cell membrane. The arrangement of this skeleton network affects the stability and the size of the compartments. We discovered that spectrin compartment size and the band3 diffusion vary from normal to disease patient's blood such as HbSS (Sickle cell...
Band 3 which is the one of the most abundant membrane protein in red blood cell membrane. It is bound to the spectrin network via other proteins such ...
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cena:
304,16 |
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The Role of Phycobilins in Cryptophyte Photosynthesis
ISBN: 9783838310121 / Angielski / Miękka / 232 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Understanding the detailed mechanisms of photosynthesis has become an ever increasingly important research field, as the community aims to apply the understandings from nature to design elements in organic photovoltaics. This thesis is a comprehensive study of the optical properties and the critical role of phycobiliproteins in the absorption of green light for photosynthesis in cryptophyte algae (Rhodomonas CS24 and Chroomonas CCMP270). Investigations of two different isolated proteins, phycoerythrin 545 and phycocyanin 645, are described in addition to investigating the workings of these...
Understanding the detailed mechanisms of photosynthesis has become an ever increasingly important research field, as the community aims to apply the u...
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cena:
353,37 |
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Folding Pathways of Photoactive Proton Pump Bacteriorhodopsin
ISBN: 9783838319438 / Angielski / Miękka / 152 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Stop-flow fluorescence and photodiode array spectroscopy, with a millisecond time resolution, are used here to investigate refolding kinetics of the photoactive proton pump bacteriorhodopsin in mixed DMPC/CHAPS micelles from a partially denatured state in SDS. The study suggests that both the apoprotein folding and subsequent binding of retinal chromophore likely proceed via distinct multiple parallel pathways to generate the native helical bundle. Taken together, these data should have profound implications on the mechanisms of folding of proteins within biological membranes.
Stop-flow fluorescence and photodiode array spectroscopy, with a millisecond time resolution, are used here to investigate refolding kinetics of the p...
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cena:
263,91 |
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Quantitative Determination of Labeled Cell Concentration Using MRI
ISBN: 9783838303390 / Angielski / Miękka / 112 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Focus of this study is to quantify the labeled cell con. using MRI. Two independent theories behind this relationship between MR parameters and labeled cell con. were proposed and tested in vitro and in vivo in rats after stroke. The first approach focused on the relationship between iron and labeled cell con. and R2p. R2p correlation with labeled cell con. is based on static dephasing regime theory. According to this theory, diffusion effects can be neglected if the protons do not migrate out of the local magnetic fields during a given echo time. R2p relaxivity agreed closely...
Focus of this study is to quantify the labeled cell con. using MRI. Two independent theories behind this relationship between MR parameters and labe...
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cena:
219,18 |
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Electrical Impedance Tomography
ISBN: 9783838340944 / Angielski / Miękka / 188 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Most EIT machines operate at high frequencies above 10 kHz. Biological systems demonstrate dispersions of electrical impedance characteristics at very low frequencies below 2 kHz due to the presence of membrane surrounding the cells and diffusion polarization effects. This book elaborate the feasibility of the use of low frequencies in a range of 1 Hz to 4.5 kHz in EIT. A frequency of 78 kHz normally used in EIT was used as a comparison. The impedance measurements employed a four-terminal method using an ultra low frequency impedance spectrometer and used conducting and insulating material as...
Most EIT machines operate at high frequencies above 10 kHz. Biological systems demonstrate dispersions of electrical impedance characteristics at very...
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cena:
304,16 |
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Beneficial Noise and Perilous Oscillations in the Nervous System
ISBN: 9783838342276 / Angielski / Miękka / 104 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Computational modeling of cooperative dynamics in excitable systems is important for uncovering mechanisms that underlie perturbation propagation in the nervous system. In this dissertation, two spatially extended networks of FitzHugh-Nagumo neurons operating in the subexcitable and hyperexcitable regime are studied by computational methods, leading to two key conclusions. First, the length and speed of perturbation propagation in the subexcitable FitzHugh-Nagumo system is maximized by spatiotemporal noise of optimal intensity. This indicates that random fluctuations in neuronal excitability...
Computational modeling of cooperative dynamics in excitable systems is important for uncovering mechanisms that underlie perturbation propagation in t...
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cena:
219,18 |
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Instrumentation for Lesion Detection
ISBN: 9783838321929 / Angielski / Miękka / 180 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. To image small lesions within the body requires instrumentation that has very high resolution, has high sensitivity, and can suppress large background signals. This can be achieved with beta-emitting radioactive tracers. To detect these tracers, the detection device must be small, compact, and placed in close proximity to the lesions, virtually touching them. This book presents design concepts, as well as the building and evaluation of such devices, for imaging vulnerable plaques and residual cancer cells. Detailed disease descriptions, as well as comprehensive references, are also presented....
To image small lesions within the body requires instrumentation that has very high resolution, has high sensitivity, and can suppress large background...
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cena:
304,16 |
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Photosynthesis -
ISBN: 9783838346106 / Angielski / Miękka / 128 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. An analysis of the consequences arising from the non- linearity of the photosynthetic light curves on the values of quantum requirement, as well as on the action spectra and quantum efficiency spectra in dependence of the suspension optical densities is presented. A kinetic model of the oxygen production reaction is elaborated in which in addition to the non-cooperative (Koks)mechanisms a cooperative one is also included. According to this model the oxygen precursors obtained in different oxygen evolving reaction centres could migrate in the surrounding media and recombine. The two...
An analysis of the consequences arising from the non- linearity of the photosynthetic light curves on the values of quantum requirement, as well as o...
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cena:
263,91 |
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