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Mechanism of Kinesin Motility
ISBN: 9783838354187 / Angielski / Miękka / 68 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Motor proteins are enzymes that are responsible for molecular transport. Those proteins convert the chemical energy derived from the hydrolysis of ATP directly into mechanical work and are necessary for the eukaryotic cell to achieve complex organizational and structural tasks. Motor proteins allow efficient transport of molecular structures and organelles such as vesicles, mitochondria, and chromosomes which is necessary since diffusion is too slow to efficiently move material from one part of the cell to another on physiological time scales [1]. This ability to control cellular transport...
Motor proteins are enzymes that are responsible for molecular transport. Those proteins convert the chemical energy derived from the hydrolysis of ATP...
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219,18 |
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Imaging of Creatine Deposits in Human CNS Tissues
ISBN: 9783838384832 / Angielski / Miękka / 132 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Synchrotron infrared spectromicroscopy and X-Ray Fluorescence spectromicroscopy have been applied to imagine human central nervous system tissue. Untreated, flash frozen tissue samples were analyzed at micron level spatial resolution to obtain information about chemical composition of the sample. Bright synchrotron light allowed the high spatial resolution (8-10 microns) needed for this study. In the family of neurodegenerative diseases, Amyotrophic Lateral Sclerosis (ALS) is the most frequent cause of adult onset. ALS symptoms include: generalized weakness and muscle atrophy. The...
Synchrotron infrared spectromicroscopy and X-Ray Fluorescence spectromicroscopy have been applied to imagine human central nervous system tissue. U...
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263,91 |
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Modelling biological systems
ISBN: 9783843353571 / Angielski / Miękka / 116 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Networks of coupled oscillators are observed in various domains of science. From physics to economy through biology, they are used to explain how collective behaviour emerges from interacting oscillators. In this book, we study through two specific examples, how biological systems use the distinctive properties of interconnected networks, widely studied in the biophysical science, to propagate informations and regulate vital physiological processes. Our interest focuses on: (1) Extension of the study of the communication via Ca2+ waves to a 1D and a 2D array of cells. (2) Communication...
Networks of coupled oscillators are observed in various domains of science. From physics to economy through biology, they are used to explain how coll...
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219,18 |
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Molecular Regulation of the Exocytic Mode in Adrenal Chromaffin Cells
ISBN: 9783843359191 / Angielski / Miękka / 292 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Neuroendocrine chromaffin cells of the adrenal medulla are a primary output for the sympathetic nervous system. Chromaffin cells release catecholamine as well as vaso- and neuro-active peptide transmitters into the circulation through exocytic fusion of large dense-core secretory granules. Under basal sympathetic firing, chromaffin cells selectively release modest levels of catecholamines, helping to set the "rest and digest" status of energy storage. Under stress activation, elevated sympathetic firing leads to increased catecholamine as well as peptide transmitter release to set the "fight...
Neuroendocrine chromaffin cells of the adrenal medulla are a primary output for the sympathetic nervous system. Chromaffin cells release catecholamine...
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353,37 |
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Impact of Load Carriage on Gait and Muscle Activity
ISBN: 9783838381848 / Angielski / Miękka / 308 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The amount of loads carried in backpacks by school children has been increasing over the last two decades raising concerns among medical practitioners and parents about the possible detrimental effects prolonged heavy load carriage can have on the musculoskeletal system. Previous studies have indicated that loads higher than 15% of body weight affect the gait and trunk posture of children and can cause long term musculoskeletal problems. It has been reported in many countries that due to the structure of the curriculum, children usually carry loads as high as 22-25% of their body weight....
The amount of loads carried in backpacks by school children has been increasing over the last two decades raising concerns among medical practitioners...
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353,37 |
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Spectroscopy of major Biochemical Compounds of Coffee Beans
ISBN: 9783838375601 / Angielski / Miękka / 112 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The molecular spectroscopy which works in the wavelength regions of UV-Vis have various applications. For quantitative determination species in mixtures, characterization of pure compound, identification of the presence or absence of a particular species in a mixture or certain functional groups in a compound. It also used to study self-association, hetero-association and thermodynamic properties of compound.Thus, in this research, the contents of caffeine and chlorogenicacids in coffee beans have been investigated by spectroscopic and theoretical methods.In addition, the optical transition...
The molecular spectroscopy which works in the wavelength regions of UV-Vis have various applications. For quantitative determination species in mixtur...
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219,18 |
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Molecular and Cellular Effects of Lllt in Diabetic Wound Healing
ISBN: 9783843370196 / Angielski / Miękka / 236 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
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353,37 |
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Microbubbles and Ultrasound
ISBN: 9783844301069 / Angielski / Miękka / 240 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Microbubbles have been used for several decades as ultrasound contrast agents in diagnostic ultrasound imaging. However, their application in gene therapy as delivery vehicles has only recently been realised. The presence of microbubbles in close proximity to cells during ultrasound insonation can increase the efficacy of drug or gene delivery by inducing sonoporation. In this research project, experimental in-house microbubbles were used in order to establish the exact parameters that lead to sonoporation. Confocal imaging and 3-D reconstruction indicated the structure, morphology and...
Microbubbles have been used for several decades as ultrasound contrast agents in diagnostic ultrasound imaging. However, their application in gene the...
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The Effect of Crystalline Defects on the Structure of Cotton Fibers
ISBN: 9783843389174 / Angielski / Miękka / 164 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Until today there are many works have been done to improve this white gold crop. This work is an attempt to study cotton fibers using X-ray technique, and I think as it looks easy but it is very useful to understand the the desired mechanical properties of cotton fiber through the crystalline structure of these fibers. In this work, I have studied the effect of crystalline structure defects on the elastic modulus of cotton fibers. As will as, I have selected different species of cotton fibers which cultivated in India and Yemen. I hope this research work will be first step to develop the...
Until today there are many works have been done to improve this white gold crop. This work is an attempt to study cotton fibers using X-ray technique,...
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304,16 |
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Computational Neuroscience of Granule Neurons
ISBN: 9783844324884 / Angielski / Miękka / 184 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. One of the biggest open challenges mathematicians and engineers face, is understanding the complex computation that takes place in our brain. Using mathematical biophysics, studies of neurons and neuronal hypotheses have become popular, thanks to increased computational resources. Analyzing neuronal processing helps determine the possible role and function of a neuron in a particular neural microcircuit. This book studies how a cerebellar granule neuron can be modeled in detail. Some properties of neurons have been noted to show its role in population coding and in network function. This book...
One of the biggest open challenges mathematicians and engineers face, is understanding the complex computation that takes place in our brain. Using ma...
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Properties of Encapsulated Chlorophyll-a in Carboxymethyl Cellulose
ISBN: 9783844306392 / Angielski / Miękka / 100 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The operation of Photosynthetic Biomaterials (PBMs) away from its native membrane environment reduces its energy transducing and photovoltaic efficiencies drastically. Such degradations are contributed to the biomaterials' loss of photo-functionality in displaced environments or as a result of reconstitution into unsuitable "artificial membrane" materials. The work involves development of suitable preparation of gel-like carboxymethyl cellulose solution as the artificial membrane to encapsulate Chlorophyll-a molecules so as to successfully mimic and retain its native spectroscopic properties...
The operation of Photosynthetic Biomaterials (PBMs) away from its native membrane environment reduces its energy transducing and photovoltaic efficien...
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219,18 |
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Radioactivity in Environmental Media
ISBN: 9783843373388 / Angielski / Miękka / 80 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. THE ACTIVITY CONCENTRATIONS OF RADIONUCLIDES AND PHYSICHOCHEMICAL PARAMETERS USED AS WATER QUALITY INDICATORS WAS MEASURED IN BOREHOLE, WELL AND STREAM SAMPLES OF OBAFEMI OWODE AND ODEDA AREA OF OGUN STATE, SOUTH WESTERN NIGERIA. THIS WAS ALSO MEASURED FOR THE PALM OIL PRODUCED LOCALLY BY THE LOCAL POPULATION. THE PHYSICOCHEMICAL PARAMETERS INDICATED LOW HYGINIC QUALITY OF THE WATERS CONSUMED BY THE LOCAL POPULATION. HIGH LEVELS OF RADIONUCLIDES WERE ALSO PRESENT BEYOND THE MAXIMUM DAILY INTAKE FOR URANIUM. THE PALM OIL SAMPLES WERE RELATIVELY OK COMPARED TO THEIR WATER COUNTERPART.
THE ACTIVITY CONCENTRATIONS OF RADIONUCLIDES AND PHYSICHOCHEMICAL PARAMETERS USED AS WATER QUALITY INDICATORS WAS MEASURED IN BOREHOLE, WELL AND STREA...
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Advanced NMR Techniques for Biomarkers Identification
ISBN: 9783843386357 / Angielski / Miękka / 128 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Nuclear Magnetic Resonance spectroscopy has emerged as a key tool for understanding metabolic processes in living systems. Recently, a new approach to elucidate metabolism and its mechanisms appeared to the scientific community scene. It is metabonomics: an analysis based on very few assumptions on the biochemical processes that occur in living systems, mainly investigated by advanced spectroscopic techniques including mass spectrometry and NMR spectroscopy. The development of new spectroscopic tools for high thoughput analysis of selected biochemical pathways is crucial for metabolome...
Nuclear Magnetic Resonance spectroscopy has emerged as a key tool for understanding metabolic processes in living systems. Recently, a new approach to...
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263,91 |
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Protein-Protein Interactions in Hetero-dimer Complexes
ISBN: 9783844385465 / Angielski / Miękka / 88 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Protein heterodimer (two dissimilar proteins) complexes are often involved in catalysis, regulation, assembly, immunity and inhibition. This involves the formation of stable interfaces between the interacting partners. The molecular principle of protein-protein binding is not fully known. Analysis of protein structures determined by X-ray crystallography in its protein dimer state provides valuable insights to the understanding of protein-protein interactions. This book documents the current opinion for the driving force in protein-protein binding using the analysis of known protein...
Protein heterodimer (two dissimilar proteins) complexes are often involved in catalysis, regulation, assembly, immunity and inhibition. This involves ...
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219,18 |
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Computational Models of Spike-Timing Dependent Plasticity
ISBN: 9783838315270 / Angielski / Miękka / 192 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This thesis work consists in a theoretical and computational study of a recently-indentified type of synaptic plasticity, called "spike-timing dependent plasticity" (STDP). The thesis is articulated in three main parts. (1) A phenomenological model of STDP is introduced based on experimental data, and the biophysical plausibility of this model is analyzed. (2) This model is then implemented in an analog-neuron simulator, in which neurons are emulated by integrated circuits (ASICs). The behavior of elementary circuits of neurons interconnected with STDP synapses is analyzed and compared to the...
This thesis work consists in a theoretical and computational study of a recently-indentified type of synaptic plasticity, called "spike-timing depende...
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304,16 |
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Probing Protein Structural Dynamics from Residual Dipolar Couplings
ISBN: 9783838303895 / Angielski / Miękka / 156 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Residual dipolar couplings (RDCs) provide
explicit information of the molecular structure and dynamics in solution at atomic level. Full utilization of RDC datasets requires the acquisition under multiple aligning conditions, which remains experimentally challenging. We have illustrated in an application to ubiquitin that molecular alignment can be modified by varying the morphological characteristics of a composite medium, composed of ordered bacteriophage Pf1 particles embedded... Residual dipolar couplings (RDCs) provide
explicit information of the molecular structure and dynamics in solution a... |
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263,91 |
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An Adaptive Evolution Strategy for Protein Folding
ISBN: 9783838374253 / Angielski / Miękka / 232 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Proteins are a group of molecules involved in practically all biological functions that owe their versatility to the ability of binding structurally complementary ligands. Due to the limitations of experimental techniques, however, the number of resolved structures is lagging behind the number of known sequences, calling for the development of structural prediction algorithms. Since the native structure corresponds to the global minimum of the free energy function, the protein folding problem can be recast in a global optimization problem. Genetic algorithms (GA) are optimization tools that...
Proteins are a group of molecules involved in practically all biological functions that owe their versatility to the ability of binding structurally c...
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353,37 |
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Exercise, Aging and Bone Tissue Quality
ISBN: 9783838366425 / Angielski / Miękka / 136 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Fractures are the most frequent health problem associated with bone and represent a significant clinical and economic burden. Fracture risk is most often assessed through bone mass scans, which measure bone quantity. However, aging and interventions like exercise have a greater influence on fracture risk than variances in mass predict, indicating that skeletal integrity is affected by alterations in tissue quality, and not just quantity. Currently, there is no clear understanding of how bone tissue quality contributes to skeletal integrity or how it can be altered by external...
Fractures are the most frequent health problem associated with bone and represent a significant clinical and economic burden. Fracture risk is most...
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263,91 |
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Development of Conductng Polymer Based Nucleic Acid Biosensors
ISBN: 9783838380513 / Angielski / Miękka / 196 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Nucleic acid biosensors have been found to have interesting possibilities for applications in various fields including environmental and medical screening. The two types of analysis used for the nucleic acid biosensors are: (a) detection of genotoxicants/ DNA damage (b) detection of DNA hybridization. For the detection of genotoxicants, the double stranded calf thymus DNA has been electrochemically entrapped into conducting polymers like Polypyrrole (PPy) and Polyaniline (PANI) films to detect chlorpyrifos and malathion. Compared to DNA-PPy, DNA-PANI electrodes have better detection limit for...
Nucleic acid biosensors have been found to have interesting possibilities for applications in various fields including environmental and medical scree...
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304,16 |
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Multi-Objective Optimal Power Flow
ISBN: 9783838379968 / Angielski / Miękka / 104 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In the past decade, the problem of optimal power flow (OPF) for improving economy and security of power system operation has received much attention. The OPF problem solution aims to optimize an objective function such as the fuel cost via optimal adjustment of the power system control variables, while at the same time satisfying various equality and inequality constraints. Generally, the OPF problem is a large- scale highly constrained nonlinear nonconvex optimization problem with several objectives. In deregulated environment, OPF is of current interest of many utilities and it...
In the past decade, the problem of optimal power flow (OPF) for improving economy and security of power system operation has received much attention...
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cena:
219,18 |
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