Kategoria BISAC: Science >> Life Sciences - Biophysics

Molecular Life Sciences: An Encyclopedic Reference is a partnership between the American Society for Biochemistry and Molecular Biology and Springer. A major encyclopedic work, it will consist of multiple volumes focusing on understanding biological phenomena at the level of molecules and their interactions that govern life processes. Articles will include those with a focus on genes and genomes, and will contain areas such as DNA Replication, Repair and Recombination, Genes: Structure and Regulation, RNA Structure, Metabolism and Catalysis, Protein Synthesis, Post-translational...

Matthias Wurl presents two essential steps to implement offline PET monitoring of proton dose delivery at a clinical facility, namely the setting up of an accurate Monte Carlo model of the clinical beamline and the experimental validation of positron emitter production cross-sections. In the first part, the field size dependence of the dose output is described for scanned proton beams. Both the Monte Carlo and an analytical computational beam model were able to accurately predict target dose, while the latter tends to overestimate dose in normal tissue. In the second part, the author...

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies.

This volume summarizes...

Annette Barchanski deals with the question how to design nanoparticles for biomedical research. She considers properties such as size, charge, biocompatibility, and functionalization of nanoparticles from a biologist's point of view in order to achieve specific cellular responses. The author discusses the structure-function relationship of nanoparticle conjugates derived from a laser-based fabrication method. Both the limits and perspectives of tunable conjugate functions are presented, providing a general outline for researchers to configure functionalized nanoparticles with a...

This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the...