Biophysical Chemistry: Molecules to Membranes is a one-semester textbook for graduate and senior undergraduate students. Developed over several years of teaching, the approach differs from that of other texts by emphasizing thermodynamics of aqueous solutions, by rigorously treating electrostatics and irreversible phenomena, and by applying these principles to topics of biochemistry and biophysics. The main sections are: (1) Basic principles of equilibrium thermodynamics. (2) Structure and behavior of solutions of ions and molecules. The discussions range from properties of bulk water...