Kategoria BISAC: Science >> Life Sciences - Biology

Systems biology is an emerging discipline that studies the underlying network structure and the dynamics of metabolism, cells or whole organisms. It aims to investigate all interacting components simultaneously and requires data from high throughput techniques. These data from the "omic" sciences are computed and used to build in silico models of biological systems that ultimately will prove to be an invaluable tool in drug development.

This book brings together the various fields of functional genomics and systems biology that provide information on metabolic function with a...

The current generation of imaging nanoparticles is diverse and dependent on its myriad of applications. This book provides an overview of how these imaging particles can be designed to fulfill specific requirements for applications across different imaging modalities. It presents, for the first time, a comprehensive interdisciplinary overview of the impact nanoparticles have on biomedical imaging and is a common central resource for researchers and teachers.

Under the name of programmed cell death (PCD) are included diverse molecular mechanisms of cell suicide which play an essential role in the development of multicellular organisms. The best known PCD mechanism in multicellular organisms is called apoptosis. However, recent studies indicate that PCD is also present in protozoa and unicellular eukaryotes. The eleven chapters of this book give the reader a comprehensive update of the progress in the understanding of the mechanisms of PCD in protozoa. The chapters have been written by experts in this field of research and are arranged following...

Just one of a series of volumes on differing aspects of hypoxia, this authoritative text focuses on cutting-edge research at the interface of hypoxia and biomedicine. Hypoxia - or lack of oxygen - is a constant threat to the human body and its vital organs, one that can take its toll in a number of situations. There are many situations in which the threat is heightened in health and disease, but mechanisms have evolved to lessen its detrimental effects. The International Hypoxia Symposia was founded to enable scientists, clinicians, physiologists, immunologists, mountaineers and other...

Developments in tissue engineering for human medicine are increasing rapidly. Advances in stem cell biology, biomaterials science and scaffold design underpin this emerging science. An equally important facet of this field is the rational design and operation of bioreactors to control the nascent tissue growth. For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed.

Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the...

Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles...

A comprehensive guide to the revolutionary area of systems biology and its application in cell culture engineering, this volume presents an overall picture of the current topics central to structural and functional genomics, proteomics, metabolomics and bioinformatics, including such hot topics as RNAi, metabolic engineering and unfolded protein response. It includes reviews of the cellular response of environmental modulation such as low temperature and osmolarity, critical assessments of the applications of metabolomics and fluxomics approaches, examination of the utility of modulation...