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Signal Transduction and Gene Activation by STAT6 - Gene Regulation Processes Involved in Type-2 Immune Polarisation
ISBN: 9783836479288 / Angielski / Miękka / 184 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The ubiquitously expressed molecule Signal transducer and activator of transcription 6 (STAT6) is one of the key factors mediating the differentiation of T helper cells of type 2 (Th2) of the immune system, which are strongly associated with the development and maintenance of allergic diseases. The theoretical part of the present work sums up the current knowledge about STAT6 and reviews in detail the literature currently existing on this subject. In the practical part of this work, three original studies are presented, which demonstrate the identification of two novel target genes of STAT6,...
The ubiquitously expressed molecule Signal transducer and activator of transcription 6 (STAT6) is one of the key factors mediating the differentiation...
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cena:
263,29 |
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DNA Replicons - Next-generation Vaccines against Allergy
ISBN: 9783836495554 / Angielski / Miękka / 132 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In this study, DNA vaccines based on alphaviral replicases (DNA replicons) were evaluated with respect to their protective and therapeutic capacity for treatment of type I allergy. DNA replicons display specific danger signals and offer an excellent safety profile based on apoptotic elimination of transfected host cells thereby preventing undesirable long-term expression of the transfected gene. Using the model allergen beta-Galactosidase in a protective approach, the results showed that a replicase-based DNA vaccine can induce a comparable immune response at a more than 1000-fold lower dose...
In this study, DNA vaccines based on alphaviral replicases (DNA replicons) were evaluated with respect to their protective and therapeutic capacity fo...
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cena:
263,29 |
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Mirror Images: Is This a Genetic Link to Spirit?/ Aubrey Nye Explores the Look-Alike Phenomena
ISBN: 9781418425548 / Angielski / Miękka / 216 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. You walk into a room and there in front of you is not a ghost, but the actual person that you know is dead. You have just talked to a friend in another country and suddenly they appear, walking down the street. You approach them, calling their name, but they do not recognize you. You see your wife sitting at the bar, talking to another man. You go over to her and she vehemently denies knowing you, showing you her license which is not that of your wife. You are sitting at a bus stop and suddenly see an old friend of yours get off the bus, but they have not aged for 20 years, and when you say...
You walk into a room and there in front of you is not a ghost, but the actual person that you know is dead. You have just talked to a friend in anothe...
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cena:
58,92 |
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Experimental Techniques in Bacterial Genetics
ISBN: 9780867201185 / Angielski / Miękka / 192 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. |
cena:
506,25 |
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The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models
ISBN: 9780521254649 / Angielski / Twarda / 510 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book considers in detail the mechanisms of a major human problem. Chromosome imbalance affects all stages of life in ways ranging from spontaneous abortion and retardation to behavioural problems and malignancy. Charles J. Epstein concerns himself with how and why a particular chromosome imbalance produces a specific phenotype. His fundamental goal is to connect chromosome aberrations with functional abnormalities in terms of gene expression, developmental and cell biology, and metabolism. Through his examination of this relationship, we learn more about normal development and function....
This book considers in detail the mechanisms of a major human problem. Chromosome imbalance affects all stages of life in ways ranging from spontaneou...
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cena:
764,10 |
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Focus on Medical Genetics & Down's Syndrome Research
ISBN: 9781600213472 / Angielski / Twarda / 195 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Medical Genetics is the application of genetics to medicine. Medical genetics is broad and varied and encompasses many different individual fields, including clinical genetics, biochemical genetics, cytogenetics, molecular genetics, the genetics of common
Medical Genetics is the application of genetics to medicine. Medical genetics is broad and varied and encompasses many different individual fields, in...
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cena:
1199,15 |
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Computational Genetics and Genomics: Tools for Understanding Disease
ISBN: 9781588291875 / Angielski / Twarda / 308 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Ultimately, the quality of the tools available for genetic analysis and experimental disease models will be assessed on the basis of whether they provide new information that generates novel treatments for human disease. In addition, the time frame in which genetic discoveries impact clinical practice is also an important dimension of how society assesses the results of the significant public financial investment in genetic research. Because of the investment and the increased expectation that new tre- ments will be found for common diseases, allowing decades to pass before basic discoveries...
Ultimately, the quality of the tools available for genetic analysis and experimental disease models will be assessed on the basis of whether they prov...
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cena:
602,40 |
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Protein Dysfunction in Human Genetic Disease
ISBN: 9781859960363 / Angielski / Twarda / 272 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This volume gives comprehensive coverage of human genetic disease mechanisms.
This volume gives comprehensive coverage of human genetic disease mechanisms.
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cena:
630,22 |
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Genetics: Critical Concepts in Social and Cultural Theory
ISBN: 9780415342308 / Angielski / Twarda / 390 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Scientific developments have always been central to conceptions of society at particular historical moments. However, the rise of molecular biology and the new genetic knowledge in the twentieth century pose particular challenges to our notions of the individual, our sense of past and future, and our relationships with the body, nature and the family. As a number of authors have suggested, the meanings of 'life itself' may be in the process of subtle transformation and many of these reconfigurations are occurring more rapidly than our ability to fully grasp their social and cultural... Scientific developments have always been central to conceptions of society at particular historical moments. However, the rise of molecular biology... |
cena:
6302,21 |
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DNA Arrays: Technologies and Experimental Strategies
ISBN: 9780849322853 / Angielski / Twarda / 184 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A quantum leap in technology took place a few years ago with the introduction of cDNA arrays that have been developed in response to the need for simultaneous analysis of the patterns of expression of thousands of genes. DNA Arrays: Technologies and Experimental Strategies offers a view of different aspects of this rapidly developing technology, including oligonucleotide and electrochemical arrays. Distinguished investigators from academia and industry provide up-to-date insights into methodological fundamentals of construction of DNA arrays, optimization of hybridization...
A quantum leap in technology took place a few years ago with the introduction of cDNA arrays that have been developed in response to the need for simu...
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cena:
921,09 |
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Biosensors and Biodetection: Methods and Protocols Volume 1: Optical-Based Detectors
ISBN: 9781603275668 / Angielski / Twarda / 452 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Biosensors combine biological recognition elements and signal conversion elements into a biodetection system. They have been developed for a wide variety of biodetection applications, offering the advantages of increased speed and ease of use compared to traditional detection methods. In Biosensors and Biodetection: Methods and Protocols, leading experts describe the major technologies in the field in extensive technical detail, allowing readers both to understand the technology and to construct similar devices. Volume 1: Optical-Based Detectors delves into direct and indirect optical...
Biosensors combine biological recognition elements and signal conversion elements into a biodetection system. They have been developed for a wide vari...
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cena:
401,58 |
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Biosensors and Biodetection: Methods and Protocols Volume 2: Electrochemical and Mechanical Detectors, Lateral Flow and Ligands for Biosensors
ISBN: 9781603275682 / Angielski / Twarda / 464 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Biosensors combine biological recognition elements and signal conversion elements into a biodetection system. They have been developed for a wide variety of biodetection applications, offering the advantages of increased speed and ease of use compared to traditional detection methods. In Biosensors and Biodetection: Methods and Protocols, leading experts describe the major technologies in the field in extensive technical detail, allowing readers both to understand the technology and to construct similar devices. Volume 2: Electrochemical and Mechanical Detectors, Lateral Flow and Ligands for...
Biosensors combine biological recognition elements and signal conversion elements into a biodetection system. They have been developed for a wide vari...
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cena:
401,58 |
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Essentials of Medical Genomics
ISBN: 9780470140192 / Angielski / Twarda / 456 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych.
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cena:
540,67 |
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Moments of Truth in Genetic Medicine
ISBN: 9780801891014 / Angielski / Miękka / 288 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Genetic research increasingly dominates medical thought and practice in the United States and in many other industrialized nations. Susan Lindee's original study explores the institutions, disciplines, and ideas that initiated the reconfiguration of genetic medicine from a marginal field in the mid-1950s to a core research frontier of biomedicine. Tracing the work of geneticists and other experts in identifying and classifying disease during the explosive period between 1950 and 1980, Lindee identifies the individual -moments of truth- that moved the field away from its eugenic past... Genetic research increasingly dominates medical thought and practice in the United States and in many other industrialized nations. Susan Lindee's ... |
cena:
135,74 |
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Ciliopathies: A Reference for Clinicians
ISBN: 9780199658763 / Angielski / Twarda / 320 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The ciliopathies are a group of rare diseases that often affect multiple systems within the body, and are caused by defects in the function or structure of cilia. When cilia go wrong, there are profound consequences; these are discussed in detail for the first time in Ciliopathies: a reference for clinicians. The book provides a clinical overview and reference to this newly emergent group of disorders ranging from Alstrom syndrome to putative ciliopathic disorders. Each chapter provides an in-depth discussion on a specific disorder, including the latest scientific research together with a...
The ciliopathies are a group of rare diseases that often affect multiple systems within the body, and are caused by defects in the function or structu...
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cena:
465,57 |
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Population Systems: A General Introduction
ISBN: 9781402068188 / Angielski / Twarda / 222 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. I had taught courses in applied ecology, population dynamics, and population management for many years and, like many of my colleagues, had grown acc- tomed to the blank stares of my students as we wove our way through the confused semantics and intricate concepts of traditional ecology and wrestled with elaborate mathematical arguments. I searched in vain for a central unifying concept on which to organize a theory of population ecology until, 30 years ago, I read a small book of essays edited by John Milsum of McGill University entitled Positive Feedback A General Systems Approach to...
I had taught courses in applied ecology, population dynamics, and population management for many years and, like many of my colleagues, had grown acc-...
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cena:
200,77 |
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Genetics of Obesity Syndromes
ISBN: 9780195300161 / Angielski / Twarda / 304 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Obesity is one of the most important contributing factors to disease throughout the world and is an area of great current interest among researchers and clinicians. The genetics of common obesity is complex, and an important thread through this labyrinth is the study of genetic syndromes in which obesity is a major component. By examining the genetic mechanisms of obesity in these syndromes, the authors will shed new light on the genetics of common obesity. This is the first book on this important and exciting new area and addreses both the molecular and clinical features of the obesity...
Obesity is one of the most important contributing factors to disease throughout the world and is an area of great current interest among researchers a...
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cena:
477,06 |
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Angewandte Humangenetik
ISBN: 9783110194654 / Angielski / Twarda / 432 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Das Fach Humangenetik hat an Bedeutung gewonnen, was auch in der Aufwertung zum Prufungsfach in der neuen Approbationsordnung fur Arzte erkennbar ist. In diesem Buch wird umfassendes, anwendungsorientiertes Wissen im Bereich Humangenetik, aus wissenschaftlicher und klinischer Perspektive dargestellt. Man kann das Buch auf 2 Ebenen lesen. Wer sich lieber an konkreten Problemen orientiert, liest entlang der 27 Fallbeispiele und benutzt die ubrigen Abschnitte zum Nachschlagen. Studenten, die einen mehr didaktisch ausgerichteten Ansatz bevorzugen, lesen die Hintergrundabschnitte, die den... Das Fach Humangenetik hat an Bedeutung gewonnen, was auch in der Aufwertung zum Prufungsfach in der neuen Approbationsordnung fur Arzte erkennbar i... |
cena:
190,56 |
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Ion Channel Diseases: Volume 63
ISBN: 9780123745279 / Angielski / Twarda / 157 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Ion channel dysfunction in humans leads to impairment of the excitable processes necessary for the normal function of several tissues, such as muscle and brain. It follows that an increasing number of human diseases have been associated with malfunctioning ion channels, many of which have a genetic component. This volume of Advances in Genetics presents a broad and comprehensive overview of the inherited channelopathies in humans, including clinical, genetic and molecular aspects of these conditions. Keeping true to the scope of the serial, novel genomic and modeling research...
Ion channel dysfunction in humans leads to impairment of the excitable processes necessary for the normal function of several tissues, such as muscle ...
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cena:
557,51 |
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Cloning: A Biologist Reports
ISBN: 9780816658268 / Angielski / Miękka / 140 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Cloning was first published in 1985. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible, and are published unaltered from the original University of Minnesota Press editions. Cloning has become in recent years a subject of widespread speculation: the word is a source of fear and wonder, the concept a jumping-off point for the fantasies of cartoonists, film producers, and novelists. With this book, cell biologist Robert Gilmore McKinnell provides the first clear scientific explanation of the procedure for general... Cloning was first published in 1985. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible... |
cena:
155,13 |