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DNA Repair Protocols
ISBN: 9781588295132 / Angielski / Twarda / 498 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The first edition of this book, published in 1999 and called DNA Repair Protocols: Eukaryotic Systems, brought together laboratory-based methods for studying DNA damage and repair in diverse eukaryotes: namely, two kinds of yeast, a nematode, a fruit fly, a toad, three different plants, and human and murine cells. This second edition of DNA Repair Protocols covers mammalian cells only and hence its new subtitle, Mammalian Systems. There are two reasons for this fresh emphasis, both of them pragmatic: to cater to the interests of what is now a largely mammalocentric DNA repair field, and to...
The first edition of this book, published in 1999 and called DNA Repair Protocols: Eukaryotic Systems, brought together laboratory-based methods for s...
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602,40 |
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Analysis of Multifactorial Diseases
ISBN: 9781859961131 / Angielski / Twarda / 368 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book evaluates the different approaches taken to the analysis of a set of complex diseases, ranging from genome scans to candidate gene association analysis.
This book evaluates the different approaches taken to the analysis of a set of complex diseases, ranging from genome scans to candidate gene associati...
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cena:
872,61 |
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Gene Therapy
ISBN: 9781859962053 / Angielski / Twarda / 360 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Gene Therapy describes the delivery systems now available to target a given tissue with specific gene or oligonucleotide sequences, and explores the utility of animal modules as test systems. In the context of selected disease states, it summarises in vitro and in vivo studies and clinical trials performed to date.
Gene Therapy describes the delivery systems now available to target a given tissue with specific gene or oligonucleotide sequences, and explores the u...
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cena:
921,09 |
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Molecular Endocrinology: Genetic Analysis of Hormones and their Receptors
ISBN: 9781859962350 / Angielski / Twarda / 280 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This text is intended to be as relevant to the specialist endocrinologist who wants to update her or his knowledge as for the less-experienced researcher familiar with the field of endocrinology.
This text is intended to be as relevant to the specialist endocrinologist who wants to update her or his knowledge as for the less-experienced researc...
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cena:
702,94 |
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Mitochondrial Function and Biogenesis
ISBN: 9783540214892 / Angielski / Twarda / 333 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Mitochondria are complex organelles, possessing a double-membrane and even their own genome, the mtDNA. They play a pivotal role in cellular metabolism, respiration, and production of ATP essential for the normal function of all human organ systems. It is not surprising, therefore, that genetic defects of mitochondrial functions cause a wide spectrum of human diseases. This book provides the first modern and truly comprehensive coverage of the biochemistry, genetics, and pathology of mitochondria in different organisms. It particularly focuses on the recent advances in our understanding of... Mitochondria are complex organelles, possessing a double-membrane and even their own genome, the mtDNA. They play a pivotal role in cellular metabo... |
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1204,83 |
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DNA Microarrays: Gene Expression Applications
ISBN: 9783540415084 / Angielski / Miękka / 140 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This complete and practical manual on expression measurement using DNA arrays covers the existing methods (from nylon macroarrays to oligonucleotide chips) and includes detailed protocols. It has been written by practising scientists who have experienced the difficulties involved in actually using microarrays, and provides helpful advice and hints on setting up these powerful but sometimes tricky methods. Software, data mining procedures and probable future developments, which should be useful to any practising scientist interested in expression measurement, are also covered in this book. It...
This complete and practical manual on expression measurement using DNA arrays covers the existing methods (from nylon macroarrays to oligonucleotide c...
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cena:
200,77 |
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Protein Complexes That Modify Chromatin
ISBN: 9783540442080 / Angielski / Twarda / 298 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packaging of DNA into higher levels of chromatin structure would suffice to repress gene expression and that the challenge to the cell would be to rescue specific sequences from these structures. The exten- sive packaging of inactive DNA was considered the primary difference between eukaryotic and prokaryotic genomes and except for that point both would be similarly regulated by cis-acting sequences and trans- acting factors. Our view of eukaryotic...
An early view of eukaryotic chromosomes was that of static structures, which stored DNA not in use within a given cell type. It was thought that packa...
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602,40 |
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Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression
ISBN: 9783540676119 / Angielski / Twarda / 190 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Discoveries about corepressors have provided new insights into the molecular basis of gene regulation, and have established surprising connections between the mechanisms of action of a wide variety of transcriptional regulators. The reviews in this volume critically discuss the nature, mechanisms of action, and physiological roles of corepressors in a diverse assortment of biological systems. Both basic and clinical investigators will be able to find relevant information. The...
Corepressors are newly discovered assemblies of proteins that play essential roles in eukaryotic gene regulation. Discoveries about corepressors have ...
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cena:
602,40 |
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Chromosomal Alterations: Methods, Results and Importance in Human Health
ISBN: 9783540714132 / Angielski / Twarda / 540 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The book helps the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and thus is of intense interest to all those interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields. The book helps the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ h... |
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803,21 |
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From Molecule to Men: Molecular Basis of Congenital Cardiovascular Disorders
ISBN: 9783798511682 / Angielski / Twarda / 246 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. From molecule to man: Medical research has indeed taken this direction, and major improvements of our understanding of the pathophysiology and epidemiology of disease have been achieved. The molecular basis of the congenital cardiovascular disorders has been extended from relatively few congenital malformations into everyday illnesses such as diabetes mellitus, hyperlipoproteinaemea, and arterial hypertension. The monogenic and, more difficult, polygenic basis for a vast majority of cardiovascular disorders are being defined more precisely from year to year. This book gives an overview of...
From molecule to man: Medical research has indeed taken this direction, and major improvements of our understanding of the pathophysiology and epidemi...
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cena:
401,58 |
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Genetic Epidemiology
ISBN: 9783836414487 / Angielski / Miękka / 144 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The accessibility of high-throughput biology data brought a great deal of
attention to disease association studies. High density maps of single nucleotide polymorphism (SNPs) as well as massive genotype data with large number of individuals and number of SNPs become publicly available. By now most analysis of the new data is undertaken by the statistics community. This study pursues a different line of attack on genetic susceptibility to complex disease that adheres to the computer science community. The main goal of disease association analysis is to identify gene variations contributing to... The accessibility of high-throughput biology data brought a great deal of attention to disease association studies. High density maps of single |
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225,29 |
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Genes, Mind, and Culture - The Coevolutionary Process: 25th Anniversary Edition
ISBN: 9789812562746 / Angielski / Twarda / 496 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Long considered one of the most provocative and demanding major works on human sociobiology, Genes, Mind, and Culture introduces the concept of gene-culture coevolution. It has been out of print for several years, and in this volume Lumsden and Wilson provide a much needed facsimile edition of their original work, together with a major review of progress in the discipline during the ensuing quarter century. They argue compellingly that human nature is neither arbitrary nor predetermined, and identify mechanisms that energize the upward translation from genes to culture. The authors also...
Long considered one of the most provocative and demanding major works on human sociobiology, Genes, Mind, and Culture introduces the concept of gene-c...
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cena:
722,33 |
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Current Topics in Human Genetics: Studies in Complex Diseases
ISBN: 9789812704726 / Angielski / Twarda / 964 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The sequencing of the human genome has brought human genetics into a new era of study resulting in the generation of an explosive amount of information. Application of genomic, proteomic, and bioinformatics technologies to the study of human genetics has made it possible for human genetic diseases to be studied on an unprecedented scale, both in silico and in the wet lab. This volume provides up-to-date coverage of the broad range of research topics in this fascinating area. In the first part of the book, a whole spectrum of approaches to human genetics research is reviewed for both...
The sequencing of the human genome has brought human genetics into a new era of study resulting in the generation of an explosive amount of informatio...
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1478,60 |
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Blood Matters: From Brca1 to Designer Babies, How the World and I Found Ourselves in the Future of the Gene
ISBN: 9780156033312 / Angielski / Miękka / 336 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Masha Gessen discovered throughgenetic testing that she had the dreaded BRCA1 genetic mutation--the same mutation made famous recently by Angelina Jolie, which predisposes women to ovarian and breast cancer. As Gessen wrestled with a wrenching personal decision what to do with such knowledge she explored the landscape of a brave new world, speaking with others like her and with experts including medical researchers, historians, and religious thinkers.Blood Matters is a much-needed field guide to this unfamiliar and unsettling territory. It explores the way genetic information is...
Masha Gessen discovered throughgenetic testing that she had the dreaded BRCA1 genetic mutation--the same mutation made famous recently by Angelina Jol...
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79,78 |
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The Practical Guide to the Genetic Family History
ISBN: 9780470040720 / Angielski / Miękka / 384 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Helps you develop and assess pedigrees to make diagnoses, evaluate risk, and counsel patients
The Second Edition of The Practical Guide to the Genetic Family History not only shows how to take a medical-family history and record a pedigree, but also explains why each bit of information gathered is important. It provides essential support in diagnosing conditions with a genetic component. Moreover, it aids in recommending genetic testing, referring patients for genetic counseling, determining patterns of inheritance, calculating risk of disease, making decisions for medical... Helps you develop and assess pedigrees to make diagnoses, evaluate risk, and counsel patients
The Second Edition of The Practical Guide t... |
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326,34 |
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Therapeutic Applications of Ribozymes
ISBN: 9780896034778 / Angielski / Twarda / 462 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The purpose of Applications Therapeutic of Ribozymes is to provide an overview of the utility of ribozymes to selectively inhibit the expression of RNA. The ribozyme applications appearing in this book should benefit not only those experienced in ribozymes, but also those applying this ribozyme technology for the first time. It is hoped that a better understanding of the therapeutic application ofribozymes will have a significant impact on human disease in the near future. The field ofribozyme biochemistry has come a long way since the initial observation that RNA is capable of catalysis,...
The purpose of Applications Therapeutic of Ribozymes is to provide an overview of the utility of ribozymes to selectively inhibit the expression of RN...
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401,58 |
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Genetics and Primary Care: An Introductory Guide
ISBN: 9781846192074 / Angielski / Miękka / 144 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Increasingly, primary care professionals are faced with challenges in dealing with patients who have been affected by a genetic disorder, or whose family history is of concern. A basic understanding of clinical genetics and the role of the genetics centres leads to greater confidence in the management of these patients. This book is an ideal introduction to the principles of genetics. It outlines the key influences that will affect primary care including screening programmes, the role of genetics education (such as the RCGP Genetics Curriculum) and national guidelines. It provides information...
Increasingly, primary care professionals are faced with challenges in dealing with patients who have been affected by a genetic disorder, or whose fam...
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179,32 |
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Technologies for Detection of DNA Damage and Mutations
ISBN: 9780306452376 / Angielski / Twarda / 441 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Man-made carcinogens, natural genotoxic agents in the environment, as well as ionizing and ultraviolet radiation can damage DNA and are a constant threat to genome integrity. Throughout the evolution oflife, complex DNA repair systems have developed in all living organisms to cope with this damage. Unrepaired DNA lesions can promote genetic alterations (mutations) that may be linked to an altered phenotype, and, if growth-controlling genes are involved, these mutations can lead to cell transformation and the development of malignant tumors. Proto oncogenes and tumor suppressor genes may be...
Man-made carcinogens, natural genotoxic agents in the environment, as well as ionizing and ultraviolet radiation can damage DNA and are a constant thr...
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cena:
602,40 |
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Chromosome Analysis Protocols
ISBN: 9780896032439 / Angielski / Miękka / 509 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Chromosomes, as the genetic vehicles, provide the basic material for a large proportion of genetic investigations, from the construction of gene maps and models of chromosome organization, to the inves tigation of gene function and dysfunction. The study of chromosomes has developed in parallel with other aspects of molecular genetics, beginning with the first preparations of chromosomes from animal cells, through the development of banding techniques, which permitted the unequivocal identification of each chromosome in a karyotype, to the present analytical methods of molecular cytogenetics....
Chromosomes, as the genetic vehicles, provide the basic material for a large proportion of genetic investigations, from the construction of gene maps ...
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cena:
602,40 |
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Molecular Epidemiology of Chronic Diseases
ISBN: 9780470027431 / Angielski / Twarda / 384 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. "I think this is an excellent book-I recommend it to anyone involved in molecular epidemiology... The 26 chapters are written by topic specialists, in an explanatory, east to read style." -BTS Newsletter, Summer 2009
"This text provides an accessible and useful handbook for the epidemiologist who wants to survey the field, to become better informed, to look at recent developments and get some background on these or simply to appreciate further the relatively rapid changes in informatic and analytical technologies which increasingly will serve and underpin future... "I think this is an excellent book-I recommend it to anyone involved in molecular epidemiology... The 26 chapters are written by topic speci...
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cena:
601,90 |
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