Kategoria BISAC: Medical >> Genetics

In the years since the publication of Susumu Ohno's 1970 landmark book Evolution by gene duplication tremendous advances have been made in molecular biology and especially in genomics. Studies of genome structure and function prerequisite to testing hypotheses of genome evolution were all but impossible until recent methodological advances.

This book evaluates newly generated empirical evidence as it pertains to theories of genomic evolutionary patterns and processes. Tests of hypotheses using analyses of complete genomes, interpreted in a phylogenetic context,...

One Hundred Years of Chromosome Research: What Remains to be Learned, offers the reader a critical analysis of the observations and experiments that shaped the last 100 years of chromosome research, as well as the ideas which prevailed during this period.
Emphasis is placed on what remains to be learned, particularly in light of reality of the sequencing of DNA which leaves the previous era of chromosome research as a prehistoric event. It is at this turning point, that well formulated questions can be asked about many of the chromosome's properties, which remain to...

The National Cancer Act of 1971 propelled the War on Cancer, mainly by tapping the vast resources of the Federal government to confront the growing cancer challenge. As a result, all cancer initiatives funded by Federal dollars were channeled through a restructured National Cancer Institute and some predicted the conquest of cancer by the nation s bicentennial. Yet, over the ensuing three decades progress in the clinical setting has been slow, and cancer remains a largely incurable disease.

After reviewing the history of cancer and its impact on the population,...

Although creatine was discovered already in the 1830s, it is only in recent years that its crucial role for human health and general well-being has been increasingly realized and appreciated. A number of beneficial health effects have been ascribed to oral creatine supplementation, such as neuroprotective, ergogenic, anti-diabetic, anti-inflammatory, antiviral, or antitumor effects. Creatine may even improve memory and intelligence. In the present book, emphasis is placed on the intricate interplay between creatine and creatine kinase function on one hand, and proper brain function,...

Molecular Genetics of Colorectal Neoplasia A Primer for the Clinician provides the latest information on the genetics of colorectal cancer within a context of basic genetics, describing the subject in understandable language and making it clinically relevant. In this way, clinicians can become familiar with genetic terms and techniques related to colorectal neoplasia, providing a background upon which to build an appreciation of future advances and an ability to include them in the practicalities of patient care.

This edition is intended for the healthcare provider...

This volume comprises the investigation of factors that may predict the response to treatment, outcome, and survival by exploring:

design considerations in molecular epidemiology, including:

• case-only
• family-based
• approaches for evaluation of genetic susceptibility to exposure and addiction pharmacogenetics
• incorporation of biomarkers in clinical trials

measurement issues in molecular epidemiology, including

• DNA biosampling methods
• principles for high-quality genotyping
• haplotypes
...