Tumor Suppressor Genes: Volume 1: Pathways and Isolation Strategies

ISBN-13: 9780896039865 / Angielski / Twarda / 2003 / 520 str.

Mary S. Melton; Wafik S. El-Deiry; Wafik S. El-Deiry

Opis

It has become clear that tumors arise from excessive cell proliferation and a c- responding reduction in cell death. Tumors result from the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emphasis shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and tumor suppressor genes function in the same pathways, providing positive and ne- tive growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Tumor suppressor genes are mutated in hereditary cancer syndromes, as well as somatically in nonhereditary cancers. In their normal state, TSGs control cancer development and p- gression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pathways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access the powerful tools now available to discover these genes, as well as their links to cell biology and growth control.

Spis treści

Part I. Known Tumor Suppressor Genes and Pathways Growth Control by the Retinoblastoma Gene Family Marco G. Paggi, Armando Felsani, and Antonio Giordano The APC Tumor Suppressor Pathway Patrice J. Morin and Ashani T. Weeraratna Hereditary Breast and Ovarian Cancer Genes Ralph Scully and Nadine Puget Hereditary Colon Cancer Genes William M. Grady and Sanford D. Markowitz Patched, Hedgehog, and Skin Cancer Anthony G. Quinn and Ervin Epstein, Jr. Tumor Suppressor Genes in Lung Cancer Arvind K. Virmani and Adi F. Gazda TP53, hChk2, and the Li-Fraumeni Syndrome Jenny Varley Genetic Alterations in Esophageal Cancer Jun-ichi Okano, Lorraine Snyder, and Anil K. Rustgi PTEN and Cancer Ramon Parsons and Laura Simpson VHL and Kidney Cancer Michael Ohh and William G. Kaelin, Jr. p16INK4A and Familial Melanoma Kapaettu Satyamoorthy and Meenhard Herlyn The INK4a/ARF Locus and Human Cancer Greg H. Enders Progression Model of Prostate Cancer Teresa Acosta Almeida and Nickolas Papadopoulos Neurofibromatosis Type 1 Margaret E. McLaughlin and Tyler Jacks Wilms' Tumor as a Model for Cancer Biology Andrew P. Feinberg and Bryan R. G. Williams Inadequate 'Caretaker' Gene Function and Human Cancer Development Theodore L. DeWeese and William G. Nelson Regulation of Tumor Suppressor Genes by Oncogenes Paul Dent, Liang Qiao, Donna Gilfor, Michael Birrer, Steven Grant, and Paul B. Fisher Part II. Identification of Tumor Suppressor Genes Determination of Cancer Allelotype Jennifer J. Ascaño and Steven M. Powell Epidemiologic Approaches to the Identification of Cancer Predisposition Genes Timothy R. Rebbeck Characterization of Translocations in Human Cancer Keri Fairand Michelle M. Le Beau Positional Approaches to Cancer Genetics Gavin P. Robertson, Linda Sargent, and Mark A. Nelson Hybrid Capture of Putative Tumor Suppressor Genes Bryan L. Betz and Bernard E. Weissman Approaches to Proteomic Analysis of Human Tumors Mamoun Ahram and Michael R. Emmert-Buck Representational Difference Analysis of Gene Expression James M. Bugni and Norman R. Drinkwater Antisense Libraries to Isolate Tumor Suppressor Genes Adi Kimchi Genetic Suppressor Elements in the Characterization and Identification of Tumor Suppressor Genes Igor B. Roninson and Andrei V. Gudkov Cross-linking Subtractive Hybridization to Identify Tumor Suppressor Genes Gen Sheng Wu Suppression Subtractive Hybridization for Identification and Functional Analysis of Tumor Suppressor Genes Iuri D. Louro, Evans C. Bailey, and J. Michael Ruppert SAGE as a Strategy to Isolate Cancer-Related Genes Kathy Boon and Gregory J. Riggins Differential Display Techniques to Identify Tumor Suppressor Gene Pathways Siham Biade and Maureen E. Murphy Detection of Mismatch Repair Gene Expression in Urologic Malignancies Fredrick S. Leach Index

O autorze

Wafik S. El-Deiry, M.D., Ph.D, is Professor of Medicine, Chief, Hematology/Oncology, Rose Dunlap Division Chair in Hematology/Oncology, and Associate Director for Translational Researchat Penn State Hershey Cancer Institute. Dr. El-Deiry is a well-respected and notable figure among cancer researchers, scientists, and clinicians. He has published almost 300 papers in his career and has over 29,000 totol citations, with an excellent h-index of 70.

Blurb

Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, leading physician scientists and academic researchers review all the known tumor suppressor genes, explain how they work, and describe how they were discovered and isolated. In many cases, the authors discuss specific genes that are frequently involved in hereditary or sporadic cancers. They also provide a detailed guide to using powerful molecular genetic, cytogenetic, proteomic, and cell biological strategies to isolate and characterize novel tumor suppressor genes and their targets. The companion volume of this set, Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, demonstrates how best to explore the cell biology and biochemical function of such genes, and their encoded proteins, to study their physiological role in vivo, and to use information on TSGs to develop diagnostic and therapeutic strategies for cancer.
Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics.