Kategoria BISAC: Medical >> Microbiology

DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries.

Pathogenic fungi are widely distributed and can infect many organisms, particularly humans, but also other vertebrates and insects. Due to a growing number of fungal infections, there is an increasing need to understand the interaction of pathogenic fungi with their hosts.

This second completely updated and revised edition of Volume VI of The Mycota consists of state of the art reviews written by experts in the field, covering three major areas of this rapidly developing field. In the first part the current understanding of pathogenic fungi and the physiological reactions relevant...

The book starts with a general introduction into the relevance of systems biology for understanding tuberculosis. This will be followed by several chapters which describe the application of systems biology to various aspects of the study of the pathogen, Mycobacterium tuberculosis, and its interaction with the host. The book provides the reader with an account of howthe new science of systems biology is providing novel insights into the ancient scourge of tuberculosis. It will also describe how systems biology can be applied to the control of tuberculosis, including the development...

• Contributions from leading authorities
• Informs and updates on all the latest developments in the field

The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified. It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice.This response is complex and includes effector functions that mediate resistance, contributing to expulsion and in some cases destruction, of the parasite.But just as importantly, the type 2 immune response can also...

An examination of the research and translational application to prevent and treat biofilm-associated diseases

In the decade since the first edition of Microbial Biofilms was published, the interest in this field has expanded, spurring breakthrough research that has advanced the treatment of biofilm-associated diseases. This second edition takes the reader on an exciting, extensive review of bacterial and fungal biofilms, ranging from basic molecular interactions to innovative therapies, with particular emphasis on the division of labor in biofilms, new approaches to...

First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies--oligonucleotide microarrays, mass spectrometry, and next-generation sequencing--and the analysis of this data through sophisticated mathematical algorithms. It is perhaps the use of mathematics, to integrate abundant...

Many breakthroughs in biological research and translational healthcare advancements have been achieved by studying the response of biological systems to extreme environments. The spaceflight platform provides a unique environment where researchers can explore fundamental questions into cellular and molecular response mechanisms to unveil novel insight into human health and disease. Since the physical force of gravity has shaped the architecture of all biological systems on our planet, spaceflight provides the opportunity to see life in a new adaptational mode - in response to reduced...

This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical...

Integration in Bioanalysis: Technologies for Point-of-Care Testing, by Frank F. Bier, Soeren Schumacher

Future of Medicine: Models in Predictive Diagnostics and Personalized Medicine, by Babette Regierer, Valeria Zazzu, Ralf Sudbrak, Alexander Kuhn and Hans Lehrach

A Highly Versatile Microscope Imaging Technology Platform for the Multiplex Real-Time Detection of Biomolecules and Autoimmune Antibodies, by Stefan Rodiger, Peter Schierack, Alexander Bohm, Jorg Nitschke, Ingo Berger, Ulrike Frommel, Carsten Schmidt, Mirko Ruhland, Ingolf Schimke, Dirk Roggenbuck, Werner Lehmann,...

The Series will provide microbiologists, hygienists, epidemiologists and infectious diseases specialists with well-chosen contributed volumes containing updated information in the areas of basic and applied microbiology involving relevant issues for public health, including bacterial, fungal and parasitic infections, zoonosis and anthropozoonosis, environmental and food microbiology.

The increasing threat of the multidrug-resistant microorganisms and the related host immune response, the new strategies for the treatment of biofilm-based, acute and chronic microbial infections, as...