DNA Repair and Human Disease

ISBN-13: 9781489998996 / Angielski / Miękka / 2014 / 150 str.

Adayabalam Balajee

Opis

DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries.

Spis treści

Human Premature Aging Disorders and Dysfunction of DNA Repair.- DNA Repair Aspects for RecQ Helicase Disorders.- Trichothiodystrophy.- Roles of the BRCA1 and BRCA2 Breast Cancer Susceptibility Proteins in DNA Repair.- Radiosensitivity of Cells Derived from Down Syndrome Patients.- The Fanconi Anemia/BRCA Pathway.- Is Ataxia Telangiectasia a Result of Impaired Coordination between DNA Repair and Cell Cycle Checkpoint Regulators?.- Mechanisms of DNA Damage and Repair in Alzheimer Disease.- Orchestration of Telomeres and DNA Repair Factors in Mammalian Cells.- Defective Solar Protection in Xeroderma Pigmentosum and Cockayne Syndrome Patients.