Hepatitis C Virus Disease: Immunobiology and Clinical Applications
ISBN: 9781441924384 / Angielski / Miękka / 308 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Despite numerous hepatitis C virus infection studies, its pathogenesis and medical treatment have not been fully explained. This comprehensive volume, written by experts in the field, covers the most recent advances in the study of HCV, moving from basic research to clinical applications. The first chapters of this volume analyze the full spectrum of immune responses to HCV. The volume also includes contributions that explain the state of the art in IFN-alpha treatment of HCV patients. Despite numerous hepatitis C virus infection studies, its pathogenesis and medical treatment have not been fully explained. This comprehensive volu... |
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cena:
585,00 zł |
Yeast Biotechnology: Diversity and Applications
ISBN: 9789048178339 / Angielski / Miękka / 744 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book updates the knowledge that we have accumulated over the last couple of decades on yeast research. The yeasts are eukaryotic unicellular microfungi that are widely distributed in the natural environment, and can also be found in more specialized or extreme environments, such as low temperatures, low oxygen availabilities and water potential. Approximately 1500 species of yeasts belonging to over 100 genera have been described so far. Although the vast majority of yeasts are beneficial to human life, only a few are opportunistic human pathogens. Yeasts play an important role in the... This book updates the knowledge that we have accumulated over the last couple of decades on yeast research. The yeasts are eukaryotic unicellular m... |
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1170,03 zł |
Plant Virology Protocols: From Viral Sequence to Protein Function
ISBN: 9781617377945 / Angielski / Miękka / 677 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Following the considerable success of the first edition of Plant Virology Protocols, this exciting new edition covers the many new techniques that are now applied to the examination and understanding of plant viruses. Each section presents the most novel methods and step-by-step reproducible laboratory protocols to allow researchers more effective approaches to study plant viruses. This updated book will prove indispensable to laboratory investigators studying plant viruses. Following the considerable success of the first edition of Plant Virology Protocols, this exciting new edition covers the many new techniques that ... |
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cena:
585,00 zł |
Checkpoint Controls and Cancer: Volume 2: Activation and Regulation Protocols
ISBN: 9781617376030 / Angielski / Miękka / 358 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Intracellular checkpoint controls constitute a network of signal transd- tion pathways that protect cells from external stresses and internal errors. Ext- nal stresses can be generated by the continuous assault of DNA-damaging agents, such as environmental mutagens, ultraviolet (UV) light, ionizing radiation, or the reactive oxygen species that can arise during normal cellular metabolism. In response to any of these assaults on the integrity of the genome, the activation of the network of checkpoint control pathways can lead to diverse cellular responses, such as cell cycle arrest, DNA...
Intracellular checkpoint controls constitute a network of signal transd- tion pathways that protect cells from external stresses and internal errors. ...
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cena:
389,98 zł |
Human Papillomaviruses: Methods and Protocols
ISBN: 9781617375262 / Angielski / Miękka / 496 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Leading basic researchers and clinical scientists describe in detail a wide variety of established and cutting-edge techniques they have developed to study the lifecycle and biological properties of the human papillomavirus. The authors use these readily reproducible methods, ranging from PCR to propagation of HPV in vitro, to detect and type papillomavirus infections, study the papillomavirus lifecycle, and to produce and functionally analyze papillomavirus proteins. The protocols follow the successful Methods in Molecular Medicine series format, each offering step-by-step laboratory...
Leading basic researchers and clinical scientists describe in detail a wide variety of established and cutting-edge techniques they have developed to ...
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cena:
428,99 zł |
Signal Transduction and the Gasotransmitters: No, Co, and H2s in Biology and Medicine
ISBN: 9781617375125 / Angielski / Miękka / 378 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the...
Distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing signaling transduction mechanis...
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cena:
585,00 zł |
Trinucleotide Repeat Protocols
ISBN: 9781617374463 / Angielski / Miękka / 342 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Trinucleotide repeats are relatively common in the human genome. These simple repeats have received much attention since epoch-making discoveries were made that particular trinucleotide repeats are expanded in the causal genes of human hereditary neurological disorders. For example, the CGG repeat is expanded in fragile X syndrome at the 5' untranslated region (UTR) of its causal gene. In myotonic dystrophy, it is the CTG repeat that is expanded at the 3' UTR of its causal gene. The CAG repeat was also found expanded in coding regions of the genes responsible for X-linked spinal and bulbar...
Trinucleotide repeats are relatively common in the human genome. These simple repeats have received much attention since epoch-making discoveries were...
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cena:
389,98 zł |
Tumor Necrosis Factor: Methods and Protocols
ISBN: 9781617374326 / Angielski / Miękka / 280 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Tumor necrosis factor (TNF)-? is a pleiotropic cytokine involved in a va- ety of physiological and pathological processes. After initial discovery of its ability to induce cell death and animal cachexia, it was soon realized that this cytokine played pivotal roles in the regulation of homeostasis and inflam- tory-immune responses. This led to an explosion of interest in basic and tra- lational research activities on the role of TNF in many diseases, such as cancer, septic shock, rheumatoid arthritis, and infectious diseases of the central n- vous system. Because of its potential therapeutic...
Tumor necrosis factor (TNF)-? is a pleiotropic cytokine involved in a va- ety of physiological and pathological processes. After initial discovery of ...
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cena:
467,99 zł |
E. Coli Plasmid Vectors: Methods and Applications
ISBN: 9781617373916 / Angielski / Miękka / 316 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A comprehensive collection of readily reproducible techniques for the manipulation of recombinant plasmids using the bacterial host E. coli. The authors describe proven methods for cloning DNA into plasmid vectors, transforming plasmids into E. coli, and analyzing recombinant clones. They also include protocols for the construction and screening of libraries, as well as specific techniques for specialized cloning vehicles, such as cosmids, bacterial artificial chromosomes, l vectors, and phagemids. Common downstream applications such as mutagenesis of plasmids, recombinant protein expression,...
A comprehensive collection of readily reproducible techniques for the manipulation of recombinant plasmids using the bacterial host E. coli. The autho...
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cena:
467,99 zł |
Cell Migration in Inflammation and Immunity: Methods and Protocols
ISBN: 9781617373572 / Angielski / Miękka / 292 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Chemokines and their receptors play a central role in the pathogenesis of numerous, perhaps all, acute and chronic inflammatory diseases. About 50 distinct chemokines produced by a variety cell types and tissues either c- stitutively or in response to inflammatory stimuli are involved in a plethora of biological processes. These small secreted proteins exert their exquisitely variegated functions upon binding to a family of seven-transmembrane spanning G-protein coupled receptors (GPCRs) composed of almost 20 distinct entities. The biological activities of chemokines range from the control of...
Chemokines and their receptors play a central role in the pathogenesis of numerous, perhaps all, acute and chronic inflammatory diseases. About 50 dis...
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cena:
389,98 zł |
Opioid Research: Methods and Protocols
ISBN: 9781617373299 / Angielski / Miękka / 307 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Opioid research is one of the multidisciplinary research areas that involve advanced techniques ranging from molecular genetics to neuropharmacology, and from behavioral neuroscience to clinical medicine. In current opioid research, it has become increasingly important to use multiple approaches at molecular, cellular, and system levels for investigations on a specific opio- related target system. That often requires understanding and applying cro- field techniques and methods for the success of one s research projects. Through its broad spectrum of coverage, Opioid Research: Methods and...
Opioid research is one of the multidisciplinary research areas that involve advanced techniques ranging from molecular genetics to neuropharmacology, ...
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cena:
389,98 zł |
Handbook of Industrial Cell Culture: Mammalian, Microbial, and Plant Cells
ISBN: 9781617373152 / Angielski / Miękka / 536 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A diverse team of researchers, technologists, and engineers describe, in simple and practical language, the major current and evolving technologies for improving the biocatalytic capabilities of mammalian, microbial, and plant cells. The authors present state-of-the-art techniques, proven methods, and strategies for industrial screening, cultivation, and scale-up of these cells, and describe their biotech and industrial uses. Special emphasis is given to the solving critical issues encountered during the discovery of new drugs, process development, and the manufacture of new and existing...
A diverse team of researchers, technologists, and engineers describe, in simple and practical language, the major current and evolving technologies fo...
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cena:
1092,02 zł |
HPLC of Peptides and Proteins: Methods and Protocols
ISBN: 9781617372865 / Angielski / Miękka / 414 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The introduction of high-performance liquid chromatography (HPLC) to the analysis of peptides and proteins some 25 years ago revolutionized the biological sciences by enabling the rapid and sensitive analysis of peptide and protein structure through the exquisite speed, sensitivity, and resolution that can be easily obtained. Today, HPLC in its various modes has become the pivotal technique in the characterization of peptides and proteins and currently plays a critical role in both our understanding of biological processes and in the development of peptide- and protein-based pharmaceuticals....
The introduction of high-performance liquid chromatography (HPLC) to the analysis of peptides and proteins some 25 years ago revolutionized the biolog...
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cena:
585,00 zł |
Capillary Electrophoresis of Carbohydrates
ISBN: 9781617372063 / Angielski / Miękka / 318 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Glycoconjugates such as glycoproteins and glycolipids play important roles in cell-cell interaction events, including development, differentiation, m- phogenesis, fertilization, inflammation, and metastasis. A number of reports have documented the association of unique oligosaccharide sequences to p- tein targeting and folding, and in mechanisms of infection, inflammation, and immunity. For glycoproteins, these glycan appendages are the result of extensive co- or post-translational modifications of the nascent proteins in the endoplasmic reticulum and in the Golgi apparatus. Although nucleic...
Glycoconjugates such as glycoproteins and glycolipids play important roles in cell-cell interaction events, including development, differentiation, m-...
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cena:
389,98 zł |
Glycoprotein Methods and Protocols: The Mucins
ISBN: 9781617371493 / Angielski / Miękka / 506 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The mucins (mucus glycoproteins) have long been a complex corner of glycoprotein biology. While dramatic advances in the separation, structural an- ysis, biosynthesis, and degradation have marked the progress in general glycop- tein understanding, the mucins have lagged behind. The reasons for this lack of progress have always been clear and are only now being resolved. The mucins are very large molecules; they are difficult to separate from other molecules present in mucosal secretions or membranes; they are often degraded owing to natural protective functions or to isolation methodology and...
The mucins (mucus glycoproteins) have long been a complex corner of glycoprotein biology. While dramatic advances in the separation, structural an- ys...
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cena:
702,00 zł |
Enzyme and Microbial Biosensors: Techniques and Protocols
ISBN: 9781617370281 / Angielski / Miękka / 264 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In 1962 Clark and Lyons pioneered the concept of a biosensor. They p- posed immobilizing enzymes at electrochemical detectors to form enzyme el- trodes in order to expand the analyte range of ther base sensor. Smce then, the field of blosensors has greatly expanded. Some of the reasons for the expansion include both advances in signal transduction technologies and the incorporation of different biological sensing elements (Table 1). As a consequence, there are now a bewildering array of permutations of the biological sensing element and signal transducers that can be used to c- struct a...
In 1962 Clark and Lyons pioneered the concept of a biosensor. They p- posed immobilizing enzymes at electrochemical detectors to form enzyme el- trode...
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cena:
389,98 zł |
Antiviral Strategies
ISBN: 9783642097959 / Angielski / Miękka / 379 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and... A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resi... |
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cena:
1170,03 zł |
Specialization and Complementation of Humoral Immune Responses to Infection
ISBN: 9783642093135 / Angielski / Miękka / 162 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The importance of specific antibodies for the clearance of and long-term resistance to many infectious pathogens has long been appreciated. Moreover, the role in these processes of the different antibody heavy chain isotypes, each tailored to induce diverse effector pathways such as those mediated by complement and Fc receptors and to promote antibody localization in distinct regions of the body, is well established. Insights into the molecular mechanism of isotype class switching showed that during an immune response B cells could change the heavy chain of the antibody they produced, without...
The importance of specific antibodies for the clearance of and long-term resistance to many infectious pathogens has long been appreciated. Moreover, ...
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cena:
585,00 zł |
Toll-Like Receptors (TLRs) and Innate Immunity
ISBN: 9783642091339 / Angielski / Miękka / 240 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention. Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead... |
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cena:
1170,03 zł |
Measles: Pathogenesis and Control
ISBN: 9783642089565 / Angielski / Miękka / 296 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Measles virus, one of the most contagious of all human viruses, has been largely contained by the development and use of a vaccine that was introduced 50 years ago. These two volumes were timed to honor the introduction of the vaccine and to record the enormous advancements made in understanding the molecular and cell biology, pathogenesis, and control of this infectious disease. Where vaccine has been effectively delivered, endemic measles virus transmission has been eliminated. However, difficulties in vaccine delivery, lack of health care support and objection to vaccination in some... Measles virus, one of the most contagious of all human viruses, has been largely contained by the development and use of a vaccine that was introdu... |
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cena:
780,00 zł |