Toll-Like Receptors (TLRs) and Innate Immunity

ISBN-13: 9783642091339 / Angielski / Miękka / 2010 / 240 str.

Stefan Bauer;Gunther Hartmann

Opis

Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.

Spis treści

Toll-Like Receptors (TLRs) and Their Ligands. Signalling of Toll-Like Receptors. TLR 9 Mediated Recognition of DNA. RNA Recognition via Toll-Like Receptors 7 and 8. Fungal recognition by TLR2 and Dectin-1. Heat Shock Proteins and Toll-Like Receptors. Nucleic Acid Recognition Receptors in Autoimmunity. DC-Subsets and Toll-Like Receptors. Structure of Toll-Like Receptors. Toll-like Receptor-Agonists in the Treatment of Skin Cancer: History, Current Developments and Future Prospects. Vaccination with Messenger RNA (mRNA)

O autorze

Stefan Bauer studierte Ethnologie in Wien und forschte in Moskau zum Thema diskursiver Präsentation indigener Kulturen. Er arbeitet derzeit im Museum für Völkerkunde in Wien.