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Mass Spectrometry in the Biological Sciences
ISBN: 9780896033405 / Angielski / Twarda / 570 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Leading practitioners describe in detail advanced methods of mass spectrometry used in structural characterization of biomacromolecules of both natural and recombinant origin. They demonstrate by example how these methodologies can solve a wide array of real-world problems in protein biochemistry, immunology, and glycobiology, as well as for human bacterial pathogens, lipids, and nucleic acids. The book offers a unique opportunity to learn these techniques that are revolutionizing the field. Its authoritative assessment in the context of how to solve important and challenging problems in...
Leading practitioners describe in detail advanced methods of mass spectrometry used in structural characterization of biomacromolecules of both natura...
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603,81 |
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Gene Targeting Protocols
ISBN: 9780896033603 / Angielski / Twarda / 233 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The potential now exists in many experimental systems to transfer a cloned, modified gene back into the genome of the host organism. In the ideal situation, the cloned gene is returned to its homologous location in the genome and becomes inserted at the target locus. This process is a controlled means for the repair of DNA damage and ensures accurate chromosome disjunction during meiosis. The paradigm for thinking about the mechanism of this p- cess has emerged primarily from two sources: (1) The principles of reaction mechanics have come from detailed biochemical analyses of the RecA protein...
The potential now exists in many experimental systems to transfer a cloned, modified gene back into the genome of the host organism. In the ideal situ...
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603,81 |
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Mhc Protocols
ISBN: 9780896035485 / Angielski / Twarda / 340 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The aim of MHC Protocols is to document protocols that can be used for the analysis of genetic variation within the human major histocompatibility complex (MHC; HLA region). The human MHC encompasses approximately 4 million base pairs on the short arm of chromosome 6 at cytogenetic location 6p21. 3. The region is divided into three subregions. The telomeric class I region contains the genes that encode the HLA class I molecules HLA-A, -B, and -C. The centromeric class II region contains the genes encoding the HLA class II molecules HLA-DR, -DQ, and -DP. In between is the class III region,...
The aim of MHC Protocols is to document protocols that can be used for the analysis of genetic variation within the human major histocompatibility com...
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603,81 |
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Autoimmune Reactions
ISBN: 9780896035508 / Angielski / Twarda / 438 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Autoimmune Reactions tackles fundamental questions about how the immune system can destroy invading microbial pathogens without causing damage to itself and other "self" systems. The authoritative experts writing here explore the mechanistic aspects of such autoimmune diseases as lupus, rheumatoid arthritis, diabetes, and autoimmune thyroid disease, and where possible delineate how malfunctioning immunological mechanisms can lead to clinical symptoms. They also discusses possible general mechanisms of autoimmune disease-e.g., molecular mimicry and dysfunctional antigen presentation-and their...
Autoimmune Reactions tackles fundamental questions about how the immune system can destroy invading microbial pathogens without causing damage to itse...
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603,81 |
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Transcription Factor Protocols
ISBN: 9780896035737 / Angielski / Twarda / 306 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The effort to sequence the human genome is now moving toward a c- clusion. As all of the protein coding sequences are described, an increasing emphasis will be placed on understanding gene function and regulation. One important aspect of this analysis is the study of how transcription factors re- late transcriptional initiation by RNA polymerase II, which is responsible for transcribing nuclear genes encoding messenger RNAs. The initiation of Class II transcription is dependent upon transcription factors binding to DNA e- ments that include the core or basal promoter elements, proximal...
The effort to sequence the human genome is now moving toward a c- clusion. As all of the protein coding sequences are described, an increasing emphasi...
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402,53 |
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Mycotoxin Protocols
ISBN: 9780896036239 / Angielski / Twarda / 244 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Mycotoxins produced by molds are common contaminants of many important crops, including wheat, corn, rice, and peanuts. Some mycotoxins are found in fruits and vegetables. These contaminants have a broad range of toxic effects, including carcinogenicity, neurotoxicity, and reproductive and developmental toxicity. The occurrence of mycotoxins in foods is an unavoidable worldwide problem. About 80 countries have imposed regulatory limits to minimize human and animal exposure to mycotoxins. Regulatory limits, including international standards, have tremendous economic impact and must be...
Mycotoxins produced by molds are common contaminants of many important crops, including wheat, corn, rice, and peanuts. Some mycotoxins are found in f...
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402,53 |
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PCR Protocols
ISBN: 9780896036277 / Angielski / Miękka / 556 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Drawing on the highly successful first edition, this newly-revised second edition covers the many advances made in PCR technology since the first book, which has been used in more than 10,000 laboratories worldwide. As PCR technology has advanced significantly since the first edition, and has expanded its use in the clinical laboratory of physician/researchers, the scope of this book is greatly expanded to enable researchers at all levels to easily reproduce and adapt PCR experiments to their own specific requirements. The meethods selected represent worked examples from many fields that can...
Drawing on the highly successful first edition, this newly-revised second edition covers the many advances made in PCR technology since the first book...
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402,53 |
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Molecular Pathology Protocols
ISBN: 9780896036819 / Angielski / Twarda / 491 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The era of molecular pathology has arrived. From its promising beg- nings in research laboratories, the field has grown, and continues to grow, to become a vital part of the care of an ever-increasing number of patients. Because of its recent emergence from the research taboratory, many molecuIar pathology protocols we still to be found in the primary litcramre, and have not appeared in a text. MO PCU Q Padhoiogy Protocob contains la- ratory protocoIs that have been developed by many of the authors for use in clinical molecular pathology laboratories and describe in detail Row to perform...
The era of molecular pathology has arrived. From its promising beg- nings in research laboratories, the field has grown, and continues to grow, to bec...
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603,81 |
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Protein Kinase Protocols
ISBN: 9780896037007 / Angielski / Twarda / 365 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The wealth of primary information provided by genome sequencing projects in various species is of enormous potential value in our efforts to understand biological funtions and molecular interactions not only in normal development and cellular physiology, but also in diseases. However, utili- tion of these resources can come only from the development and application of a fully integrated set of molecular, biochemical, biophysical, and genetic skill bases. As key components of many cell signalling pathways, protein kinases are implicated in a broad variety of diseases, including cancers and...
The wealth of primary information provided by genome sequencing projects in various species is of enormous potential value in our efforts to understan...
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402,53 |
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Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic
ISBN: 9780896037243 / Angielski / Twarda / 512 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative,...
Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. C...
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805,10 |
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Antigen Processing and Presentation Protocols
ISBN: 9780896037458 / Angielski / Twarda / 270 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Antigen processing and presentation, as a field, explores a broad range of protein interactions and functions, both intracellular (in the cytoplasm and in the endoplasmic reticulum) and at the cell surface (between T cells and MHC molecules). To investigate such a diverse array, it is necessary that biochemical, cell biology, and immunological techniques all be employed. The purpose of Antigen Processing and Presentation Protocols is therefore to detail the most up-to-date techniques being used in this burgeoning field. Such techniques include those used to question how MHC-binding peptides...
Antigen processing and presentation, as a field, explores a broad range of protein interactions and functions, both intracellular (in the cytoplasm an...
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402,53 |
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Vascular Disease and Injury: Preclinical Research
ISBN: 9780896037533 / Angielski / Twarda / 348 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. A panel of expert clinical researchers offer a practical guide to the key animal models used in vascular disease. These experts examine critical issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension. Up-to-date and highly practical, Vascular Disease and Injury: Preclinical Studies provides a comprehensive review that not only illuminates the current status of cardiovascular...
A panel of expert clinical researchers offer a practical guide to the key animal models used in vascular disease. These experts examine critical issue...
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805,10 |
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Handbook of Bacterial Adhesion
ISBN: 9780896037946 / Angielski / Twarda / 644 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Research on bacterial adhesion and its significance is a major field involving many different aspects of nature and human life, such as marine science, soil and plant ecology, most importantly, the biomedical field. The adhesion ofbacteria to the food industry, and human tissue surfaces and implanted biomaterial surfaces is an important step in the patho- genesis of infection. Handbook 0/ Bacterial Adhesion: Principles, Methods, and Applications is an outgrowth of the editors' own quest for information on laboratory techniques for studying bacte- rial adhesion to biomaterials, bone, and other...
Research on bacterial adhesion and its significance is a major field involving many different aspects of nature and human life, such as marine science...
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805,10 |
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Capillary Electrophoresis of Carbohydrates
ISBN: 9780896038264 / Angielski / Twarda / 318 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Glycoconjugates such as glycoproteins and glycolipids play important roles in cell-cell interaction events, including development, differentiation, m- phogenesis, fertilization, inflammation, and metastasis. A number of reports have documented the association of unique oligosaccharide sequences to p- tein targeting and folding, and in mechanisms of infection, inflammation, and immunity. For glycoproteins, these glycan appendages are the result of extensive co- or post-translational modifications of the nascent proteins in the endoplasmic reticulum and in the Golgi apparatus. Although nucleic...
Glycoconjugates such as glycoproteins and glycolipids play important roles in cell-cell interaction events, including development, differentiation, m-...
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402,53 |
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The Nucleic Acid Protocols Handbook
ISBN: 9780896038417 / Angielski / Miękka / 478 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. There can be no doubt that some ofthe most spectacular advances made in science over the past few decades have been in the isolation, analysis, and manipulation of nucleicacids. Thishas ledtoamuchgreaterunderstandingofmechanismsandprocesses across many fields of bioscience, such as biochemistry, microbiology, physiology, pharmacology, and the medical sciences to name a few. It has also led to the growth of the biotechnology industry, which seeks to develop and commercialize many ofthese important processes and methods. Much ofthis has come about because ofthe devel- opment of numerous...
There can be no doubt that some ofthe most spectacular advances made in science over the past few decades have been in the isolation, analysis, and ma...
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805,10 |
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Cystic Fibrosis Methods and Protocols
ISBN: 9780896038974 / Angielski / Twarda / 615 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Since the cloning of the cystic fibrosis transmembrane conductance re- lator (CFTR) nearly a decade ago, cystic fibrosis (CF) research has witnessed a dramatic expansion into new scientific areas. Basic researchers, clinicians, and patients increasingly rely on fundamental techniques of genetics, molecular biology, electrophysiology, biochemistry, cell biology, microbiology, and immunology to understand the molecular basis of this complex disease. Research into the pathophysiology of CF has established numerous paradigms of ion channel dysfunction that extend from inflammation and infection...
Since the cloning of the cystic fibrosis transmembrane conductance re- lator (CFTR) nearly a decade ago, cystic fibrosis (CF) research has witnessed a...
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603,81 |
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Gtpase Protocols: The Ras Superfamily
ISBN: 9780896039346 / Angielski / Twarda / 267 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In the last 10 years researchers have firmly established key roles for R- related GTPases in almost every aspect of cell biology. In the 1980s the pro- oncogene Ras itself was the focus of interest, though in the 1990s this shifted to the increasing variety of Ras-related proteins. In this new decade much yet needs to be done to establish the role for all the small GTPases now uncovered by the human genome project. In particular, these GTPases need to be und- stood in the appropriate biochemical and cellular contexts. In the process of trying to uncover the role of these versatile proteins, a...
In the last 10 years researchers have firmly established key roles for R- related GTPases in almost every aspect of cell biology. In the 1980s the pro...
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402,53 |
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Cytokine Protocols
ISBN: 9780896039483 / Angielski / Twarda / 240 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. During the last 30 years there has been a growing interest in cytokines as biological molecules able to regulate the most diverse functions in living org- isms, mainly at the level of cell-cell communication. Originally their definition was limited to the cells of the immune system (interleukins and lymphokines), but later that definition was extended to all cells, and their regulatory activity in such other processes as differentiation, apoptosis, angiogenesis, and wound he- ing has been now demonstrated. They comprise a group of small proteins (5-20 kDa) produced and released by cells in a...
During the last 30 years there has been a growing interest in cytokines as biological molecules able to regulate the most diverse functions in living ...
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402,53 |
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Hemoglobin Disorders: Molecular Methods and Protocols
ISBN: 9780896039629 / Angielski / Twarda / 300 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Hemoglobin and Hemoglobinologists This volume, Hemoglobin Disorders: Molecular Methods and Protocols, will be introduced with a review of the great milestones in the field, and the scientists responsible for those achievements. The history of hemoglobin can be divided into three periods: the Classical period, the Modern period, and the Post-Modern period. I am inclined to include as the four major members of the classical period Francis Roughton, Quentin Gibson, Jeffries Wyman, and Linus Pauling, not only because of their achievements, but also because of the superb scientists they trained...
Hemoglobin and Hemoglobinologists This volume, Hemoglobin Disorders: Molecular Methods and Protocols, will be introduced with a review of the great mi...
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402,53 |
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Superantigen Protocols
ISBN: 9780896039841 / Angielski / Twarda / 259 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Superantigen Protocols assembles experimental protocols that have proved useful for the study of superantigens. These techniques will allow researchers from various areas of cell biology, microbiology, immunology, biochemistry, and molecular biology to assess the physical characteristics and biological effects of well-known superantigens as well as of putative substances that might have superantigenic activities, and to explore therapies for superantig- induced effects. Microbial exotoxins have been studied for decades as virulence factors because of their pathogenic effects. The term...
Superantigen Protocols assembles experimental protocols that have proved useful for the study of superantigens. These techniques will allow researcher...
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cena:
402,53 |
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