We live in an era of "explosions." Not the least threatening of these inflationary events is the information explosion. In spite of data banks, automated indexes, and computerized retrieval systems, science is being overflooded by its products. Much of the responsibility for this state of affairs must rest with a system that tends to reward quantity rather than quality of publications, and on the resulting misap- prehension that the aim of scientific research is the gathering of data rather than the advancement of knowledge. The sponsors of congresses and symposia who insist on a lasting...

The contents of this monograph "Hypothalamic Control of Lacta tion" are the result of studies by a nine-man team which has worked together for nine years. The topic is so fascinating that new research students are attracted to it every year, and the circle is growing steadily. This is, in fact, part of a much more extensive research field to which our Department is applying itself at present, viz. "Hypo thalamic Pharmacology." Our work in this sphere was made possible by a generous grant from the United States Department of Agriculture, which helped us during the first 5 years of research...

This is the story of steroid-protein interactions as one investigator sees it. Following the general concept of this monograph series, it emphasizes the results and interpretations obtained in the author's laboratory, and is therefore a subjective account. Recognizing, how ever, that the discussion of the subject would be incomplete if the material were limited to one scientist's work, the essential achieve ments of other investigators have been incorporated. An effort has thus been made to give a balanced presentation and to enable the reader to see in perspective the varied facets of the...

Soon after the discovery of insulin in 1922, it became clear that the use of this hormone in the treatment of diabetics is often accom panied by allergy. In 1956 it became possible to determine quantita tively the insulin-binding antibodies which are responsible for the resistance to insulin. The methods developed since then make it possible to measure minute amounts of the pancreatic hormone in blood and extracellular fluids. There have been many attempts to relate insulin allergy and in sulin resistance to the primary, secondary or tertiary structure of the or B chains, or both, and more...

This book was written at the invitation of Dr. H. GOTZE of Springer-Verlag for the series "Monographs in Endocrinology." It is not a comprehensive account of the prostaglandins but has been writ ten with a deliberate emphasis upon those aspects of the field in which I am particularly interested and to which, in some cases, I have made a contribution. I am grateful to Miss E. PFISTERER and her colleagues of Springer Verlag for their excellent work. I should also like to thank my wife without whose patience, encouragement and help this book would never have been completed. Finally this is an...

Upon wresting the control of the earth from the Titans, Zeus assigned the task of creating living creatures to two Titan brothers who had sided with him in the epic battle just concluded. Because Epimetheus, who had been endowed only with hindsight, had the first hand in this creation, all the good attributes were exhaus ted by the time the lion, the elephant and other animals were created. When the time came for the creation of man, there were precious few materials left to work with. Not surprisingly, man was made weak and naked. Prometheus took pity on this miscreation and gave man the use...

Because diseases of the bone are often less acute and less lifethreatening than dis eases of the circulatory system, gastrointestinal tract, kidney, liver, and the nervous system, they have received a disproportionately smaller amount of attention in the medical world. With the average increasing life span of man as a result of improve ments in modern medicine, espe ially in the pediatric field, the seriousness of many metabolic bone diseases has indeed become more obvious. In addition, other improvements in medicine, such as hemodialysis for the preservation of renal failure patients, have...

It is the object of this series of monographs to present the experiments and interpre- tations of a given laboratory. We have attempted in this volume to present our view of receptor-steroid interactions and their relation to steroid-induced responses. This view is necessarily biased by our own experimental results. While we have tried to in- clude the views and results of others, this volume is not meant to be comprehensive. Rather it is selective and examines those topics within the general field of steroid hor- mone action which we have addressed at the laboratory bench. The work reviewed...

Research on the hormonal control oflactation - the subject of this monograph - has long been the major interest of this laboratory. Studies were initiated in the mid 1930s by the late Professor S. 1. Folley, FRS, who directed the work with immense enthusiasm and devotion until his untimely death in 1970. This fruitful area of basic and applied research has, in recent years, attracted widespread attention; there have been many exciting events and developments with a dramatic increase in the number of publications.These events are diverse and include the identification, isolation and sequencing...

The building of conceptual models is an inherent part of our interaction with the world, and the foundation of scientific investigation. Scientists often perform the processes of modelling subconsciously, unaware of the scope and significance of this activity, and the techniques available to assist in the description and testing of their ideas. Mathematics has three important contributions to make in biological modelling: (1) it provides unambiguous languages for expressing relationships at both qualitative and quantitative levels of observation; (2) it allows effective analysis and...