Glucocorticoid Hormone Action

ISBN-13: 9783540089735 / Angielski / Miękka / 1979 / 640 str.

J. D. Baxter; G. G. Rousseau

Opis

We live in an era of "explosions." Not the least threatening of these inflationary events is the information explosion. In spite of data banks, automated indexes, and computerized retrieval systems, science is being overflooded by its products. Much of the responsibility for this state of affairs must rest with a system that tends to reward quantity rather than quality of publications, and on the resulting misap- prehension that the aim of scientific research is the gathering of data rather than the advancement of knowledge. The sponsors of congresses and symposia who insist on a lasting record of their proceedings, the authors and editors who have no compunc- tion about printing trivial or redundant information, and the publishing houses them- selves, which can hardly be expected to favor restraint, also bear part of the respon- sibility. One of the consequences of the information explosion is a change in our attitude towards new books. Whereas we used to welcome their appearance and to take them as useful and good until proven otherwise, we now greet them with suspicion and wonder even before opening them whether they were really necessary. Fortunately, some of them still are and perform a real service by taking an unwieldy mass of data dispersed in a variety of journals, and organizing it into a coherent synthesis of the state of knowledge in a given field. Such books actually serve to advance knowledge and become landmarks.

Spis treści

1 Glucocorticoid Hormone Action: An Overview.- 2 Delivery and Transport of Glucocorticoids to Target Cells.- 3 Glucocorticoid Receptors.- 4 Structure and Conformation of Glucocorticoids.- 5 Structure-Activity Relationships in Glucocorticoids.- 6 Approaches for Purification of the Glucocorticoid Receptor.- 7 Allosteric and Competitive Steroid-Receptor Interactions.- 8 Nuclear Binding of Glucocorticoid Receptors.- 9 Factors Influencing Association of Glucocorticoid Receptor-Steroid Complexes with Nuclei, Chromatin, and DNA: Interpretation of Binding Data.- 10 The Glucocorticoid Domain of Response: Measurement of Pleiotropic Cellular Responses by Two-Dimensional Gel Electrophoresis.- 11 Glucocorticoid Induction of Tyrosine Aminotransferase in Cultured Cells.- 12 Multihormonal Control of Tyrosine Aminotransferase in Isolated Liver Cells.- 13 Hormonal and Developmental Modulation of Tryptophan Oxygenase mRNA.- 14 Regulation of Mouse Mammary Tumor Virus Gene Expression by Glucocorticoid Hormones.- 15 Regulation of Growth Hormone Messenger RNA.- 16 Posttranscriptional Regulation of Glucocorticoid-Regulated Functions.- 17 Mechanisms of Glucocorticoid Receptor Function.- 18 Effects of Glucocorticoids on Fibroblasts.- 19 Glucocorticoid Receptors and Actions in Rat Thymocytes and Immunologically Stimulated Human Peripheral Lymphocytes.- 20 Mouse Lymphoma Cells: Mechanisms of Resistance to Glucocorticoids.- 21 Glucocorticoid Receptors and Effects in Human Lymphoid and Leukemic Cells.- 22 Somatic Cell Fusion in the Study of Glucocorticoid Action.- 23 Variations in Cellular Sensitivity to Glucocorticoids: Observations and Mechanisms.- 24 Immunosuppressive and Anti-Inflammatory Effects of Glucocorticoids.- 25 Influences of Adrenocortical Hormones on Pituitary and Brain Function.- 26 Glucocorticoids and Differentiation.- 27 Glucocorticoids and Hepatic Glycogen Metabolism.- 28 Regulation of Gluconeogenesis by Glucocorticoids.- 29 Inhibition of Glucose Transport in Fat Cells and Activation of Lipolysis by Glucocorticoids.- 30 Glucocorticoids and the Plasma Membrane.- 31 Glucocorticoids and Lysosomes.- 32 Synergistic and Antagonistic Effects of Glucocorticoids on Insulin Action.- 33 The Role of Glucocorticoid Hormones as Biological Amplifiers.- 34 Glucocorticoids and the Metabolic Code.