This volume presents the thoroughly revised proceedings of the ICSE '94 Workshop on Joint Research Issues in Software Engineering and Human-Computer Interaction, held in Sorrento, Italy in May 1994.
In harmony with the main objectives of the Workshop, this book essentially contributes to establishing a sound common platform for exchange and cooperation among researchers and design professionals from the SE and HCI communities. The book includes survey papers by leading experts as well as focused submitted papers. Among the topics covered are design, processes, user interface technology and...

This volume provides broad insights to the most recent discoveries in telomere biology, with current applications in tumor diagnostics and future potentials in therapy. Special features of diverse organisms are presented, with ciliates, the "telomerase discoverer organisms"; yeasts, the "molecular genetisists' toy for eukaryotes"; including plants and insects as well. 28 chapters were written by a group of leading research scientists, working in the telomere/telomerase fields today. This book will be a core reference for any physician, scientist or "educated reader" with an interest in the...

Wnt genes code for a family of secreted glycoproteins which fulfil important functions during the development of vertebrates and invertebrates. Wnts regulate as different aspects as differentiation, proliferation, cell migration, and cell polarity. Wnt proteins are able to activate different intracellular signaling cascades.
This book describes different aspects of Wnt signaling during development of different species like the mouse, Xenopus, chicken, C. elegans or Drosophila and in different cellular contexts like heart formation or limb bud patterning. By doing such, this book provides,...

Translation Mechanisms provides investigators and graduate students with overviews of recent developments in the field of protein biosynthesis that are fuelled by the explosive and synergic growth of structural biology, genomics, and bioinformatics.
The outstanding progress in our understanding of the structure, dynamics, and evolution of the prokaryotic and eukaryotic translation machinery, as well as applications in medicine and biotechnology, are described in 26 chapters covering recent discoveries on:

-the subtleties of tRNA aminoacylation with natural and unnatural amino acids....

This title encompasses over 30 years of progress towards our understanding of calcium channel structure, function, regulation, physiology, pharmacology, and genetics. It balances contributions from many of the leading authorities in the calcium channel field with fresh perspectives from risings stars in the area.

The B7-CD28 family molecules are probably the most intensively studied receptor-ligand systems in the field of immunology. This is evident from the explosive accumulation of literature, particularly in the last ten years. Recent years have witnessed rapid discoveries and characterization of new receptors and ligands in the family. These new pathways, although still in their infancy, have already brought much excitement to the field. However, until now, there has been no single volume to cover this entire area. This book was created to bring together state-of-the-art information and critical...

This book is unique in providing pertinent information on the various established roles carbohydrate play in the immune system and how the innate and adaptive immune systems respond to this type of microbial antigens.
The editors selected only topics that have established basic and clinical relevance to this field. The topics from basic research are organised like a textbook, in order to guide the readers through complex sets of events that lead to clearance of or to immune responses toward carbohydrate antigens. The book is clear, concise and contains fully annotated summaries of the key...

aintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu M lar calcium levels, by acting on bone, kidney and intestine. The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic...

Protein Kinase C is a pivotal component of the mechanism that allows a cell to respond to its changing environment. In this book, the most significant advances in recent basic research on Protein Kinase C are explained by active researchers in the field. The first seven chapters provide a comprehensive account of the fundamental structural and biochemical properties of Protein Kinase C. The remaining chapters contain overviews of the function of Protein Kinase C, both in lower organisms and in mammalian cells, the latter with a focus on immune cells and nerve cells.
This book is the only...

As the first comprehensive overview of the nucleolus since 1985, The Nucleolus covers our current understanding of the cell nucleolus, including its role in ribosome assembly and its additional newly-discovered activities. The eighteen chapters have been written by experts who are actively engaged in research on the nucleolus and have an in depth review of the following topics:

- nucleolar ultrastructure and dynamics,
- behavior during mitosis,
- ribosomal DNA gene and chromatin structure,
- pre-ribosomal RNA transcription,
- processing and modification,
- ribosome...