Voltage-Gated Calcium Channels

ISBN-13: 9781441934116 / Angielski / Miękka / 2010 / 378 str.

Gerald Werner Zamponi

Opis

This title encompasses over 30 years of progress towards our understanding of calcium channel structure, function, regulation, physiology, pharmacology, and genetics. It balances contributions from many of the leading authorities in the calcium channel field with fresh perspectives from risings stars in the area.

Spis treści

Preface ................................................................................................ xiv 1. Ca2+ Chemistry Storage and Transport in Biologic Systems: An Overview .......................................................................................... 1 Tashi G. Kinjo and Paul P.M. Schnetkamp Why Ca2+ Unique Chemical and Physical Features ............................... 1 Ca2+ Evolution a Rejection from Cytoplasm .......................................... 2 Ca2+ Signaling and Storage the Endoplasmic Recticulum ...................... 2 The Role of Ca2+ within the ER ............................................................ 3 ER Heterogeneity Ca2+ Tunneling Versus Ca2+ Compartmentalization .............................................................. 3 Ca2+ Signaling and Storage Mitochondria ............................................. 4 Mitochondrial Ca2+ Uptake Function and Effects ................................. 4 Ca2+ Buffering; Cytosolic and Lumenal ................................................. 5 Channels that Lead to an Increase in Cytosolic Ca2+ .......................................... 5 Intracellular Ca2+ Release Channels ....................................................... 6 Plasma Membrane Ca2+ Channels ......................................................... 7 Cyclic Nucleotide-Gated Channels ........................................................ 7 P2X Receptors ....................................................................................... 7 SOCE and the TRP Gene Family ......................................................... 8 Mechanisms of Store-Operated Ca2+ Entry ........................................... 8 Mechanisms to Lower Cytosolic Ca2+ .......................................................................... 8 PMCA Gene Family .............................................................................. 9 SERCA Gene Family ............................................................................. 9 NCX Gene Family ................................................................................ 9 NCKX Gene Family.............................................................................. 9 2. Monitoring Intracellular Ca2+ in Brain Slices with Fluorescent Indicators .................................................................. 12 Sean J. Mulligan and Brian A. MacVicar Ca2+ Sensitive Fluorescent Chemical Indicators ................................... 12 Single-Wavelength Probes ................................................................... 13 Dual-Wavelength Ratiometric Probes ................................................. 15 Ca2+ Binding Affinity .......................................................................... 16 Ca2+ Indicator Form ............................................................................ 18 Dextran Conjugates ............................................................................. 18 AM-Esters ........................................................................................... 20 Quantitative Measurement of [Ca2+]i .................................................. 21 3. A Brief History of Calcium Channel Discovery .................................... 27 Richard W. Tsien and Curtis F. Barrett The Key Role of Ca2+ Channels in Cellular Signaling .......................... 27 The Winding Road of Calcium Channel Discovery ............................ 30 The Diversity of Native Ca2+ Channel Currents .................................. 36 4. Biochemical Studies of Voltage-Gated Ca2+ Channels .......................... 48 William A. Catterall Purification and Bioche