Telomerases, Telomeres and Cancer

ISBN-13: 9781441933911 / Angielski / Miękka / 2010 / 422 str.

Guido Krupp; Reza Parwaresch

Opis

This volume provides broad insights to the most recent discoveries in telomere biology, with current applications in tumor diagnostics and future potentials in therapy. Special features of diverse organisms are presented, with ciliates, the "telomerase discoverer organisms"; yeasts, the "molecular genetisists' toy for eukaryotes"; including plants and insects as well. 28 chapters were written by a group of leading research scientists, working in the telomere/telomerase fields today. This book will be a core reference for any physician, scientist or "educated reader" with an interest in the exciting developments in this research field.

Spis treści

Section I: Telomerases, Telomeres and Cancer. Section Ia: Telomerase Activity and Cancer. 1. The Significance of Quantitative Evaluation of Telomerase Activity and hTERT mRNA Expression in Colorectal Cancers; M. Pogessi, et al. 2. The Role of Telomerase De-Regulation in Keratinocyte Immortality and the Progression of Human Head and Neck Cancer; E.K. Parkinson. 3. Telomerase in Mesothelioma: Diagnostic and Therapeutic Applications; K. Dhaene. 4. Telomerase Activity in Mesenchymal Tumors; R. Schneider-Stock, et al. 5. Telomerase Activity in Neuroblastomas: A New Molecular Marker for Treatment Stratification and Prognostic Grouping; C. Poremba, B. Dockhorn-Dworniczak. 5. Telomerase and Radiosensiticity of Human Tumors; T.K. Pandita. 7. Amplification of hTERT, the Telomerase Reverse Transcriptase Gene in Human Cancers; D. Xu, et al. 8. Telomerase Activity as a Marker of Tumor Cell Survival to Evaluate Sensitivity of Neoplastic Cells to Cancer Treatment; I. Faraoni, E. Bonmassar. 9. PNA and Oligonucleotide Inhibitors of Human Telomerase; G. Gavory, S. Balasubramanian. 10. Potential of the Telomerase Catalytic Subunits as a Universal Tumor-Associated Antigen for Cancer Immunotherapy; R.H. Vonderheide, W.C. Hahn. Section II: Structure and Function of Telomerase and Telomeres. Section IIa: Humans. 11. The Making of Telomerases; J. Lingner, C. Wenz. 12. Regulation of Telomerase Activity; J.-P. Liu, et al. 13. Telomeres and Mechanisms of DNA Double Strand Break Repair; P. Slijepcevic. 14. Roles for hTERT and Telomerase in Cell Differentiation and Apoptosis; M.P. Mattson, et al. Section IIb: Ciliates, Yeasts and other Eukaryotes. 15. Human, Mouse and Yeast Telomerase; T.J. Moriarty, C. Autexier. 16. The Biology of Telomeres in Hypotrichous Ciliates^* 17. DNA Primer Extension by Telomerase; H. Manor, et al. 18. Yeast Telomerases: Structure, Mechanisms and Regulation; N.F. Lue. 19. RAP1 Binding and Length Regulation of Yeast Telomeres; J. Wahlin, M. Cohn. 20. Linear Plasmids in Yeasts and Filamentous Fungi; L. Civitelli, F. Ascenzioni. 21. New Telomere Formation During the Process of Chromatin Diminution in the Parasitic Nematodes Ascaris suum and Parascaris univalens; F. Müller. 22. Telomerase Activity in Sponges (Porifera), the Closest Related Taxa of the Hypothetical Ancestral Animal the Urmetazoa; W.E.G. Müller. 23. Structure and Maintenance of Chromosome Ends in Plants; J. Fajkus, U. Zentgraf. Section III: Maintaining Telomeres without Telomrase. 24. Telomeres without Telomerase in Saccharomyces cerevisiae; E.J. Louis. 25. Recombinational Telomere Elongation in the Yeast Kluyveromyces lactis; M.J. McEachern. 26. Telomere Maintanance in Human Cell Lines and Tumors without Telomerase; C.L. Fasching, R.R. Reddel. Section IV: Non-Classical Telomere Structures. 27. Telomeres in Drosophila and Other Insects; H. Biessmann, et al. 28. Mitochondrial Telomeres: Alternative Solutions to the End-Replication Problem; J. Nosek, L. Tomaska. Index.