Despite remarkable progress in genome science, we are still far from a clear understanding of how genomic DNA is packaged without entanglement into a nucleus, how genes are wrapped up in chromatin, how chromatin structure is faithfully inherited from mother to daughter cells, and how the differential expression of genes is enabled in a given cell type. Exploring and answering these questions constitutes one of the next frontiers in the 21st century.
We are just beginning to appreciate how Multifarious DNA structures provide additional structural and functional dimensions to...
Despite remarkable progress in genome science, we are still far from a clear understanding of how genomic DNA is packaged without entanglement into...
Nuclear Import and Export in Plants and Animals provides insight into the remarkable mechanisms of nuclear import and export. This book covers a range of topics from the nuclear pore structure, to nuclear import and export of macromolecules in plant and animal cells. In addition, the book covers the special cases of nuclear import of Agrobacterium T-DNA during plant genetic transformation, nuclear import and export of animal viruses, and nuclear intake of foreign DNA. A chapter on research methods to study nuclear transport concludes the book.
Nuclear Import and Export in Plants and Animals provides insight into the remarkable mechanisms of nuclear import and export. This...
Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT).
The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural...
Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid con...
Toll Receptors and the Renaissance of Innate Immunity Elizabeth H. Bassett and Tina Rich Overview n the last few pages of Immunology: The Science of Self-Nonself Discrimination Jan Klein ponders on what he would study if he were to start over in the lab. DEGREES Dismissing the I antibody, MHC, the T-cell and parasitology, he considers instead the phylogeny of immune reactions, particularly in ancient phyla. As for a favored cell he chooses the macrophage. Describ ing it as a DEGREES DEGREESMddchenfUr alles," (all purpose kitchen maid) Klein believed that this immunocyte still had secrets to...
Toll Receptors and the Renaissance of Innate Immunity Elizabeth H. Bassett and Tina Rich Overview n the last few pages of Immunology: The Science of S...
Selective Sweep deals with the theory and practice of detection of recent adaptive evolution at the genomic level from the patterns of DNA polymorphism. Recent advances in genomic sequencing provide the background for analysis of polymorphic sites in large chromosomal regions or even in whole genome, thus providing the tool for effective identification of loci that are under strong pressure of positive selection. For this reason, the studies of selective sweep, which formerly were of interest mostly to evolutionists, have become widely recognized and appreciated by the...
Selective Sweep deals with the theory and practice of detection of recent adaptive evolution at the genomic level from the pattern...
Viral Genome Packaging focuses on the process of genome "packaging" within a pre-formed viral procapsid. The chapters of this book concentrate on the biochemistry, enzymology and structural aspects of the genome packaging machinery. This book defines a broad mechanistic basis for the process across the prokaryotic and eukaryotic border, and for DNA and RNA viruses. The biochemical, biophysical and structural aspects of genome packaging are examined in detail.
Viral Genome Packaging focuses on the process of genome "packaging" within a pre-formed viral procapsid. The chapters of this book...
aintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, responds to hypocalcemia to increase extracellu M lar calcium levels, by acting on bone, kidney and intestine. The recent intro duction of PTH as a major therapeutic agent in osteoporosis has directed renewed interest in this important hormone and in the physiology of the parathyroid gland. The parathyroid is unique in that low serum calcium stimulates PTH secretion. As hypocalcemia persists, there is also an increase in PTH synthesis. Chronic...
aintaining extracellular calcium concentrations within a narrow range is critical for the survival of most vertebrates. PTH, together with vitamin D, ...
oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar macological targets in the treatment of a variety of disorders, such as epi lepsy, hypertension, and pain. Voltage-gated calcium channels have there fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first...
oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the reg...
This book contains the written contributions to the program of the First In ternational Conference on Computer Vision, Virtual Reality, and Robotics in Medicine (CVRMed'95) held in Nice during the period April 3-6, 1995. The articles are regrouped into a number of thematic sessions which cover the three major topics of the field: medical image understanding, registration problems in medicine, and therapy planning, simulation and control. The objective of the conference is not only to present the most innovative and promising research work but also to highlight research trends and to foster...
This book contains the written contributions to the program of the First In ternational Conference on Computer Vision, Virtual Reality, and Robotics i...
