Heat shock proteins are produced when a cell is stressed by various environmental insults. Their omnipresence and extraordinary conservation in function and structure have few, if any, precedence in biology. This volume, containing contributions by well-known experts in the field, summarizes recent progress concerned with the role of heat shock proteins in immunology. Eleven outstanding chapters include topics such as the chaperonin function of heat shock proteins, their role in immunoglobulin assembly and antigen processing, as well as their involvement in inflammation. Due to their...
Heat shock proteins are produced when a cell is stressed by various environmental insults. Their omnipresence and extraordinary conservation in functi...
The eighth workshop in this series on Mechanisms in B-Cell Neoplasia 1990 was held in Wilson Hall at the National Institutes of Health, Bethesda, Maryland on March 28-30. Five major topics formed the basis for the discussions: 1) progress in experimental models of B-cell tumorigenesis, 2) the role of IL-6 in plasma cell tumor formation with particular emphasis on human myeloma, 3) immortaliza- tion and regulation of mitosis in B-cells, 4) the mYQ gene in B-cell neoplasia, and 5) the role of EBV and other oncogenes in transforma- tion of human B-Iymphocytes. A meeting on the Epidemiology of...
The eighth workshop in this series on Mechanisms in B-Cell Neoplasia 1990 was held in Wilson Hall at the National Institutes of Health, Bethesda, Mary...
Pioneering work on hepatitis B virus and hepatitis delta virus, and the discovery of hepatitis B-like virus in animals during the 1970's has been followed, over the past ten years, by an explosion of interest in how these viruses replicate, maintain chronic infections, and cause liver disease and hepatocellular carcinoma. The purpose of this book is two-fold. First, the authors of each chapter provide a summary of their specialty that will not only serve as an introduction, but will also provide the newcomer to hepatitis B virology with up-to-date information and insights into the goals and...
Pioneering work on hepatitis B virus and hepatitis delta virus, and the discovery of hepatitis B-like virus in animals during the 1970's has been foll...
There has been no literature up to now treating the Bunyaviridae in general as a family. The book demonstrates how they are maintained in nature and how they replicate and sometimes cause disease.
There has been no literature up to now treating the Bunyaviridae in general as a family. The book demonstrates how they are maintained in nature and h...
Understanding the mechanisms involved in intracellular movement and localization of proteins is a central issue in cell biology. This volume is concerned with the events involved in the transport of membrane proteins, and the contents of vesicular compartments, to their ultimate destinations. In several chapters, particular attention is given to studies with viruses that are assembled by budding at specific membrane sites within the cell or at the cell surface; studies with such viral systems have provided significant insights into membrane biogenesis.
Understanding the mechanisms involved in intracellular movement and localization of proteins is a central issue in cell biology. This volume is concer...
Our current understanding of a/ T cell receptor (TCR) ex- pressing T cells advanced from function and specificity to the molecular organization ofthe TCR.We now know that the TCR a and chains together express specificity for (antigenic) peptides presented by the "responder" M H C allele, thus explain- ing the phenomenon of MHC restriction at a molecular level. Surprisingly even though our perception of the molecular organization of the y5 TCR is well advanced, current knowledge of function and specificity of the y5 T cell subset is poor. There- fore it appeared rather timely to bring together...
Our current understanding of a/ T cell receptor (TCR) ex- pressing T cells advanced from function and specificity to the molecular organization ofthe ...
An integrated retrovirus effectively becomes part of the cellular genome, but with the difference that the virus to a large extent retains control over its own expression through nontranslated sequences in the long terminal repeat (L TR). Some retroviruses also code for nonstructural proteins that further regulate proviral expression. Integration changes the cell genome; it adds viral genes, and in the case of transducing retroviruses also adds cell-derived oncogenes that have been incorporated into the viral genome. Integration can also have consequences for cellular genes. The...
An integrated retrovirus effectively becomes part of the cellular genome, but with the difference that the virus to a large extent retains control ove...
In spite of a long history of intense investigation the transmissible spongiform encephalopathies remain a poorly understood family of neurodegenerative diseases. This group of diseases has been described in a wide variety of animal species and includes kuru, Creutzfeldt-Jakob disease, and Gerstmann-Straussler syndrome in humans, and scrapie, bovine spongiform encephalopathy, and related syndromes in ruminants and rodents. In all cases spongiform degeneration and astrocytosis are seen in specimens of brain and a filterable transmissible agent is present in the brain and some other tissues of...
In spite of a long history of intense investigation the transmissible spongiform encephalopathies remain a poorly understood family of neurodegenerati...
Many RNA viruses have been known for decades to be genetically and biologically quite variable. Some well-known examples are influenza viruses, foot and mouth disease viruses, and Newcastle disease virus. During the past decade, it has become clear that most, it not all., RNA viruses (riboviruses and retroviruses) are much more mutable than was recognized previously, and that this great mutability generates extremely complex populations consisting of indeterminate mixtures of related variants (Le., "mutant swarms" or "quasispecies" populations). This is also true of DNA viruses (such as...
Many RNA viruses have been known for decades to be genetically and biologically quite variable. Some well-known examples are influenza viruses, foot a...
Nitric Oxide (NO) an endogenous free radical, has been shown recently to mediate several important biological effects. It plays a neuro-transmitter like role in vascular endothelium, a scond-messenger role in N-methyl-D-aspartate (NMDA) responsive neurons in the central nervous system (CNS), a neurotoxic role after its release from these neurons, and a cytotoxic role after its release by macrophages. This volume reviews among other topics the basic chemistry and physical properties of S-nitrosothiols (RS-NO) and their biochemical mechanisms of action, NO synthase isozymes, NO synthase...
Nitric Oxide (NO) an endogenous free radical, has been shown recently to mediate several important biological effects. It plays a neuro-transmitter li...