The Role of Nitric Oxide in Physiology and Pathophysiology

ISBN-13: 9783642791321 / Angielski / Miękka / 2011 / 90 str.

Hilary Koprowski;Hiroshi Maeda

Opis

Nitric Oxide (NO) an endogenous free radical, has been shown recently to mediate several important biological effects. It plays a neuro-transmitter like role in vascular endothelium, a scond-messenger role in N-methyl-D-aspartate (NMDA) responsive neurons in the central nervous system (CNS), a neurotoxic role after its release from these neurons, and a cytotoxic role after its release by macrophages.
This volume reviews among other topics the basic chemistry and physical properties of S-nitrosothiols (RS-NO) and their biochemical mechanisms of action, NO synthase isozymes, NO synthase structure, mechanisms of NO synthesis, regulation of NOS expression and posttranslational modification, and mechanisms involving NO of CNS's damage in virus infections.

Recenzje

"In the past six years, the field of nitric oxide research has undergone explosive growth.... This volume can be taken as a short introduction to the field of nitric oxide research. For the advanced student or the scientist who wants a quick impression of major aspects of this field it may be a good introduction ...." Journal of Chemical Neuroanatomy

Spis treści

List of Contents.- Inducible Nitric Oxide Synthase: Regulation Subserves Function.- Diffusible Messengers and Intercellular Signaling: Locally Distributed Synaptic Potentiation in the Hippocampus.- Nitric Oxide Formation in the Vascular Wall: Regulation and Functional Implications.- S-Nitrosothiols and the Bioregulatory Actions of Nitrogen Oxides Through Reactions with Thiol Groups.- A New Nitric Oxide Scavenger, Imidazolineoxyl N-Oxide Derivative, and Its Effects in Pathophysiology and Microbiology.- The Role of Nitric Oxide in the Pathogenesis of Virus-Induced Encephalopathies.- The Role of Peroxynitrite in Nitric Oxide-Mediated Toxicity.- Regulation and Dysregulation of Constitutive Nitric Oxide Synthases Types I and III.