Heat Shock Proteins and Immune Response

ISBN-13: 9783642758775 / Angielski / Miękka / 2011 / 214 str.

Stefan H.E. Kaufmann

Opis

Heat shock proteins are produced when a cell is stressed by various environmental insults. Their omnipresence and extraordinary conservation in function and structure have few, if any, precedence in biology. This volume, containing contributions by well-known experts in the field, summarizes recent progress concerned with the role of heat shock proteins in immunology. Eleven outstanding chapters include topics such as the chaperonin function of heat shock proteins, their role in immunoglobulin assembly and antigen processing, as well as their involvement in inflammation. Due to their widespread distribution and high conservation, heat shock proteins also represent interesting antigens. The T-cell population expressing a gamma/delta receptor may have a particular predilection for heat shock proteins which allows them to identify targets stressed by various assaults. Heat shock proteins may also be central to tumor immunity and to host-parasite interactions. Furthermore, heat shock proteins could provide a link between infection and autoimmunity.

Spis treści

List of Contents.- Basic Features of Heat Shock Proteins.- Heat Shock Proteins hsp60 and hsp70: Their Roles in Folding, Assembly, and Membrane Translocation of Proteins.- Response of Mammalian Cells to Metabolic Stress; Changes in Cell Physiology and Structure/Function of Stress Proteins.- Heat Shock Protein Genes and the Major Histocompatibility Complex.- Heat Shock Protein Functions Related to Immunity.- BiP—A Heat Shock Protein Involved in. Immunoglobulin Chain Assembly.- A Role for Heat Shock Proteins in Antigen Processing and Presentation.- Heat Shock Proteins and Inflammation.- Heat Shock Proteins as Antigens.- Stress-Induced Proteins in Immune Response to Cancer.- Heat Shock Proteins as Virulence Factors of Pathogens.- Heat Shock Proteins as Antigens of Bacterial and Parasitic Pathogens.- Stress Proteins, Autoimmunity, and Autoimmune Disease.- Gamma/Delta T Lymphocytes and Heat Shock Proteins.