Adverse drug reactions (ADRs) endanger patients' health and pose a challenge to drug development and medical care. Predicting ADRs still fails in many cases due to their idiosyncrasy and limited assay or cross-species translatability. Findings from diverse sources need to be contextualised with individual patient conditions, e.g., diseases, genotypes, or co-medications, to enable a systemic understanding and reliable predictions of ADRs. However, experiments mimicking realistic patient scenarios are often expensive, infeasible, and insufficient. Here, mechanistic in silico models have emerged...

Climate change represents a severe global issue also driven by the consumption of fossil fuels, which ultimately release greenhouse gases into the atmosphere. Simultaneously, the rising demand for food, energy, and chemicals requires a shift from fossil to sustainable raw materials. Utilizing renewable carbon sources (i.e., biomass, CO2, organic waste) ensures a fossil-free future. Over recent years, itaconate has gained increasing interest as a prospective bio-based platform chemical. To replace nowadays petroleum-derived substances like methacrylic acid in industrial applications, enhancing...

Methyl ketones with a hydrocarbon chain length of C4 to C17 are currently produced from petrochemical resources, and there is only limited research on sustainable production and purification of those in the scope of a circular bioeconomy. This work elucidates sustainable bioprocesses to produce methyl ketones. For this, microbial production of methyl ketones was integrated into the preceding and consecutive process steps and optimized beyond the isolated figures of merit.

Building a sustainable society requires moving beyond the linear produce-use-waste model reliant on fossil resources. A circular bioeconomy using CO2-derived one carbon (C1) molecules as feedstocks could be a potential alternative. This work explores the methylotrophic yeast Ogataea polymorpha as a production platform for the conversion of the C1 molecules methanol and formate into industrially relevant low molecular weight biochemicals.

Ginseng is a traditional plant in Chinese medicine because it includes pharmaceutical ginsenosides that have been used in Asia for thousands of years. Ginsenosides are triterpenoids, a class of natural products mainly present in Panax species (e.g., Panax ginseng, P. notoginseng, and P. quinquifolium). However, due to the shortcomings of chemical synthesis and extraction from plants, the synthesis of ginsenosides by microbial cell factories, which has the advantages of environmental friendliness, high efficiency, convenience, and potentially low cost, has received much attention in recent...