Methyl ketones with a hydrocarbon chain length of C4 to C17 are currently produced from petrochemical resources, and there is only limited research on sustainable production and purification of those in the scope of a circular bioeconomy. This work elucidates sustainable bioprocesses to produce methyl ketones. For this, microbial production of methyl ketones was integrated into the preceding and consecutive process steps and optimized beyond the isolated figures of merit.