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wyszukanych pozycji: 14
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Development of Directly Compressible Co-processed Excipients
ISBN: 9783844398397 / Angielski / Miękka / 208 str. Termin realizacji zamówienia: ok. 10-14 dni roboczych. Direct compression method in tableting is widely used due to fewer processing steps, simplified validation, elimination of heat and moisture, economy and improved drug stability. Hence, the current trend in the pharmaceutical industry is to adopt direct compression technology. Most of the drugs do not possess direct compression characteristic. Hence, development of various functionality added excipients (FAEs) to achieve formulations with desired effects is equally important. Excipients with improved functionality can be obtained by developing new chemical excipients, new grades of existing...
Direct compression method in tableting is widely used due to fewer processing steps, simplified validation, elimination of heat and moisture, economy ...
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cena:
357,51 zł |
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Development of Compression Coated Colon Targeted 5-Fluorouracil Tablet
ISBN: 9783659221941 / Angielski / Miękka / 2012 / 112 str. Termin realizacji zamówienia: ok. 10-14 dni roboczych. The purpose of this study was to develop and evaluate a drug delivery system in vitro based on a compression coated tablet containing 5-fluorouracil (5-FU) in core and pectin Hydroxypropyl Methylcellulose (HPMC) mixture in coat layer. The main reason for selecting pectin was its biodegradation in colon by colonic flora. On other hand, high molecular weight HPMC increases mechanical strength of tablet coat around a drug core during its transportation in gastro-intestinal tract. Multiple regression analysis with two way ANOVA revealed that both factors had statistically significant influence...
The purpose of this study was to develop and evaluate a drug delivery system in vitro based on a compression coated tablet containing 5-fluorouracil (...
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cena:
221,75 zł |
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Developement and Standardisation of Anti-Diarrhoeal Herbal Capsule
ISBN: 9783659163500 / Angielski / Miękka / 2012 / 96 str. Termin realizacji zamówienia: ok. 10-14 dni roboczych. |
cena:
221,75 zł |
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Standardization & Evaluation of laxative activity of 'Dindayal Churna' : Standardization & Evaluation of laxative activity
ISBN: 9783659165214 / Angielski / Miękka / 2012 / 124 str. Termin realizacji zamówienia: ok. 10-14 dni roboczych. |
cena:
267,00 zł |
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Fast dissolving tablet of levocetrizine hydrochloride
ISBN: 9783659159008 / Angielski / Miękka / 2012 / 108 str. Termin realizacji zamówienia: ok. 10-14 dni roboczych. Levocetrizine hydrochloride is an oral antihistamine and antiallergic agent, which blocking histamine receptors. It does not prevent the actual release of histamine from mast cells, but prevents it binding to its receptors. This in turn prevents the release of other allergy chemicals and increased blood supply to the area, and provides relief from the typical symptoms of hey fever and rhinitus allergic condition. The dose of Levocetrizine hydrochloride ranges from 5 to 10 mg twice in a day and it undergoes extensive first pass metabolism. Hence it has only 66% bioavailability. The half life...
Levocetrizine hydrochloride is an oral antihistamine and antiallergic agent, which blocking histamine receptors. It does not prevent the actual releas...
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cena:
221,75 zł |
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Mouth Dissolving Tablet of Olanzapine by Solid Dispersion Technique
ISBN: 9783659133084 / Angielski / Miękka / 2012 / 136 str. Termin realizacji zamówienia: ok. 10-14 dni roboczych. In the present investigation, solid dispersion of olanzapine has been prepared to improve its solubility. Further, using solid dispersion, mouth dissolving tablet was prepared to overcome the problem of swallowing. A Simplex Lattice design was applied using three factors, i.e. superdisintegrants like croscarmellose sodium(X1) crospovidone(X2), and sodium starch glycolate(X3) in tablet formulation. Disintegration time, Wetting time, Water absorption, T50 (Time required to 50% drug release) and Q10 (percentage of drug released in 10 min.) taken as responses. Solid dispersion showed significant...
In the present investigation, solid dispersion of olanzapine has been prepared to improve its solubility. Further, using solid dispersion, mouth disso...
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cena:
267,00 zł |
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Sustained Release Tablet of Itopride Hydrochloride
ISBN: 9783659151507 / Angielski / Miękka / 2012 / 128 str. Termin realizacji zamówienia: ok. 10-14 dni roboczych. Itopride, a novel prokinetic agent is unique and different from the available prokinetics because of its dual mode of action and lack of significant drug interaction potential. Itopride is a newly developed prokinetic agent, which enhances gastric motility through both anti-dopaminergic and anti-acetylcholinesterage actions. It is best candidate for Gastro Esophageal Reflux Disease. Itopride 50mg can be given thrice in a day for Treatment of GERD. By developing the sustain release formulation of Itopride hydrochloride, the frequency of drug can be reduce to once only to obtain good...
Itopride, a novel prokinetic agent is unique and different from the available prokinetics because of its dual mode of action and lack of significant d...
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cena:
267,00 zł |
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Anti-Tussive Activity of In-House Designed and Marketed Formulation
ISBN: 9783659156168 / Angielski / Miękka / 2012 / 140 str. Termin realizacji zamówienia: ok. 10-14 dni roboczych. For evaluation of granules containing different herb parameters tested for raw material were organoleptic, physicochemical, physical, phytochemical etc. Parameters for finished product (granules) include pH, LOD, angle of repose, tapped density, bulk density, Carrs index, Hausners ratio. Marketed formulation consists of aqueous extract of G. glabra, Z. officinalis and A. vasica indicated for sore throat, cough, cold and flu. Results indicated that Raw material of Marketed formulation and Developed formulation were identical with respect to all organoleptic, physicochemical, physical, and...
For evaluation of granules containing different herb parameters tested for raw material were organoleptic, physicochemical, physical, phytochemical et...
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cena:
267,00 zł |
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Design & Developement of Floating Tablet of Tolperisone Hydrochloride
ISBN: 9783659136061 / Angielski / Miękka / 2012 / 160 str. Termin realizacji zamówienia: ok. 10-14 dni roboczych. Tolperisone hydrochloride has a short elimination half- life and rapidly absorbed from gastrointestinal tract.2 If it is formulated by conventional tablets, it will require multiple daily administrations (2-3 times daily) which ultimately results into in conveniency to the patients and possibility of reduced compliance with prescribed therapy. Tolperisone HCl is more stable in acidic medium (pH > 4.5),and in alkaline medium (pH 4 to 7) tolperisone breaks down into 4-MMPPO and piperidine. Thus, the patient is exposed to an uncontrollable quantity of...
Tolperisone hydrochloride has a short elimination half- life and rapidly absorbed from gastrointestinal tract.2 If it is formulated by conventional ta...
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cena:
307,73 zł |
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Design and Development of Extended Release Tablet of Nicotinic acid
ISBN: 9783659151880 / Angielski / Miękka / 2012 / 120 str. Termin realizacji zamówienia: ok. 10-14 dni roboczych. Nicotinic acid (NA) as lipid lowering agent drug has not become a first-line treatment due to the strong side effect called flushing occurs when given in immediate release dosage form. The tablets were prepared by wet granulation method using HPMC K-15M, polymer as retardant and the prepared tablets of NA will remain intact up to 2 hrs in pH 1.2 due to Eudragit L 100-55 and its release is not only initiated but tact fully retarded up to 12 hrs and were found to be superior in physical properties,dissolution characteristics, and drug content uniformity. The drug release from the matrix tablet...
Nicotinic acid (NA) as lipid lowering agent drug has not become a first-line treatment due to the strong side effect called flushing occurs when given...
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cena:
267,00 zł |
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Fast Release Rabeprazole Sodium Tablet Using Acid-buffer Technology
ISBN: 9783848485291 / Angielski / Miękka / 2012 / 104 str. Termin realizacji zamówienia: ok. 10-14 dni roboczych. The present invention is aimed to formulate the non-enteric formulation of immediate release rabeprazole sodium tablet using acid-buffer technology. The formulation comprising the core tablet containing rabeprazole sodium compression coated with buffer containing super disintegrant. The coat formulation disintegrates fast which provide the higher pH environment then the core formulation gives drug release so degradation of rabeprazole sodium can prevent. From the above perception, the invention is aimed: 1.To study the pH stability of rabeprazole sodium in at different pH medium. 2.To select...
The present invention is aimed to formulate the non-enteric formulation of immediate release rabeprazole sodium tablet using acid-buffer technology. T...
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cena:
221,75 zł |
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Development of Colon Targeted Hydrogel Tablet of Methotrexate
ISBN: 9783846544969 / Angielski / Miękka / 2012 / 128 str. Termin realizacji zamówienia: ok. 10-14 dni roboczych. Colorectal cancer is second leading cause of deaths in the United States. Various approaches available for The poor site specificity of pH dependent systems, because of large variation in the pH of gastrointestinal tract, was well established. The timed-release systems release their load after a predetermined period of administration. These are designed to resist the release of the drug in stomach and small intestine and release of the drug takes place in colon. Methotrexate (MTX) is a used in the treatment of colon cancer and now a days rheumatic disease. MTX is a folate antimetabolite. MTX...
Colorectal cancer is second leading cause of deaths in the United States. Various approaches available for The poor site specificity of pH dependent s...
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cena:
267,00 zł |
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Formulation and Evaluation of Pulsatile Release Tablet of Lornoxicam
ISBN: 9783659151491 / Angielski / Miękka / 2012 / 132 str. Termin realizacji zamówienia: ok. 10-14 dni roboczych. The aim of present research work is to develop single pulse pulsatile release tablets that release Lornoxicam instantly after the lag time of about 5 hour which can be used for treatment of rheumatoid arthritis where symptoms are at their prime in the morning hours. Such a pulsatile release tablet of Lornoxicam taken at bed time and release the drug in early morning, thus enhance patient compliance. From various approaches erodible compression coating system is selected for the formulation of pulsatile release tablets, in which outer coating containing mixture of hydrophilic polymer (sodium...
The aim of present research work is to develop single pulse pulsatile release tablets that release Lornoxicam instantly after the lag time of about 5 ...
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cena:
267,00 zł |
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Innovatioon 5-Fluoruracil Sr Tablets for Colon Cancer Treatment
ISBN: 9783848499205 / Angielski / Miękka / 2012 / 80 str. Termin realizacji zamówienia: ok. 10-14 dni roboczych. The use of polymeric matrix devices to control the release of variety of therapeutic agents has become increasingly important in development of the modified release dosage forms. The device may be a swellable, hydrophilic monolithic systems, an erosion controlled monolithic system or a non erodible system. The initial burst release of 5-Fluoruracil from such matrix tablet surface can be controlled by compression coating technology. Appropriate combination of hydrophilic polymer in upper and lower layer of tablet can govern the release of 5-fluoruracil as well as lag time to deliver it in...
The use of polymeric matrix devices to control the release of variety of therapeutic agents has become increasingly important in development of the mo...
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cena:
221,75 zł |
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