Design & Developement of Floating Tablet of Tolperisone Hydrochloride

ISBN-13: 9783659136061 / Angielski / Miękka / 2012 / 160 str.

Ravi Soni; Mukesh Patel; Natvarlal Patel

Opis

Tolperisone hydrochloride has a short elimination half- life and rapidly absorbed from gastrointestinal tract.2 If it is formulated by conventional tablets, it will require multiple daily administrations (2-3 times daily) which ultimately results into in conveniency to the patients and possibility of reduced compliance with prescribed therapy. Tolperisone HCl is more stable in acidic medium (pH > 4.5),and in alkaline medium (pH 4 to 7) tolperisone breaks down into 4-MMPPO and piperidine. Thus, the patient is exposed to an uncontrollable quantity of 4-MMPPO[2methyl-1-(4methylphenyl)-propanone]. Proposed are floating tolperisone tablets with the controlled release of the active substance tolperisone in the stomach at pH 1 to 2.

O autorze

Ravikumar P. SoniShri B.M. Shah College of Pharmaceutical Education and Research. Education:I received my B. Pharm from Vidya bharti trust college of pharmacy in 2010 (with English), my M. Pharm from Gujarat Technological university in 2012 (with English).