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Development of a pharmaceutical product is essentially a technique where in physicochemical properties of an active ingredients, excipients and manufacturing process are manipulated to achieve desired qualities in pharmaceutical finished dosage form. Certain goals such as product specifications, ease of manufacturing cost etc are defined for a dosage form prior to initiating the development work. The traditional trial and error approach may be less dependable and more time consuming and often provides an approximately or marginally ...

The use of polymeric matrix devices to control the release of variety of therapeutic agents has become increasingly important in development of the modified release dosage forms. The device may be a swellable, hydrophilic monolithic systems, an erosion controlled monolithic system or a non erodible system. The initial burst release of 5-Fluoruracil from such matrix tablet surface can be controlled by compression coating technology. Appropriate combination of hydrophilic polymer in upper and lower layer of tablet can govern the release of 5-fluoruracil as well as lag time to deliver it in...

Various approaches have been paused to increase the duration of oral dosage form in the stomach, including floating systems, swelling and expanding system, modified shape system, high density systems and other delayed gastric emptying devices. (Magnetic systems, Super porous biodegradable hydrogel systems). Hydrodynamically balanced systems (HBS) incorporated buoyant materials enable the device to float. Raft systems incorporate alginate gels these have a carbonate component and, upon reaction with gastric acid, bubbles form in the gel, enabling floating. Swelling type of dosage form are such...