Use of Mechanistic Information in Risk Assessment: Proceedings of the 1993 Eurotox Congress Meeting Held in Uppsala, Sweden, June 30-July 3, 1993

ISBN-13: 9783642786426 / Angielski / Miękka / 2011 / 312 str.

Hermann M. Bolt; Bj Rn Hellman; Lennart Dencker

Opis

The book contains the invited papers held at the EUROTOX 1993 congress in Uppsala, Sweden. It provides up-to-date information on recent developments in toxicology. Special emphasis is put on the area of risk assessment where more mechanistic input from basic toxicology is needed. The book also includes a series of papers on the recent status of pollution of the Baltic Sea. Research on Baltic Sea ecotoxicology is an internationalt commitment ofthe countries of this area. Due to the political development of the pastfew years, combined efforts and programs in this field will be possible.

Spis treści

Baltic Sea Pollution.- Ecology of the Baltic — Introduction.- Presence and Sources of Pollutants in the Baltic Sea.- Interrelationship Between Eutrophication and Effects of Pollutants.- Effects of Toxic Metal Pollutants on the Ecology of the Baltic Sea.- Effects of Persistent Organic Pollutants on Biota in the Baltic Sea.- Human Health Risk Assessment and Risk Perception Related to the Baltic Sea.- Contact and Respiratory Sensitisation.- Immunoregulation of T Cell-Mediated Skin Hypersensitivity.- Test Methods for Contact Sensitisation.- Test Methods for Respiratory Sensitisation.- Newer Approaches to the Evaluation of Sensitisation Phenomena.- Risk Assessment of Sensitizing Agents.- Developmental Toxicity.- Nuclear Retinoic Acid Receptors and Regulation of Gene Expression.- The Role of Retinoids in Normal Development and Retinoid-Induced Malformations.- Retinoid Teratogenesis: Toxicokinetics and Structure-Specificity.- The Neurochemical Effects of PCB Exposure are Age-Dependent.- Risk Estimation and Primary Prevention of Birth Defects.- Role of Mechanistic Studies of Toxicity in Risk Assessment.- The Role of Mechanistic Studies in Understanding Target Organ Toxicity.- Rational Species Extrapolation of Toxic Effects.- Predicting the Toxic Dose or Concentration. Is there a Difference?.- The Role of Investigative Toxicology in Pharmaceutical Industry.- Mechanisms of Metal Toxicity.- Metal-Induced Autoimmunity.- Genotoxic Effects of Metal Compounds.- Toxicokinetics of Drugs.- The Importance of Exposure Measurements in Risk Assessment of Drugs.- The Impact of Genetic Polymorphisms in Risk Assessment of Drugs.- Kinetic Analysis Using Positron Emission Tomography.- The Application of Modelling in Toxicokinetics.- Alterations in Kinetic Parameters Resulting in Modification of Toxicity.- Mechanisms of Carcinogenicity and Risk Assessment.- Importance of Genetic Alterations in Tumour Development.- Transgenic Mouse Models in Chemical Carcinogenesis Studies.- Cell Proliferation and Cell Death in Rat Liver Carcinogenesis by Chemicals.- Use of Mechanistic and Other Data in Identifying Carcinogens: A Review Based on the IARC Monographs Programme.- Late Manuscripts.- Developmental Toxicity — Magnitude of the Problem.- Health Problems Related to Respiratory Sensitisation.- Young Scientists Poster Award.- Neonatal Exposure to the Organophosphate DFP Induces Changes in Behaviour and Muscarinic Receptor Density in the Adult Mous.