Smart Nanomaterials Targeting Pathological Hypoxia

ISBN-13: 9789819917174 / Angielski

Sonam Chawla; Sachidanand Singh; Azamal Husen

Opis

The present medical sciences identify pathological hypoxia as etiological as well as causative in a wide range of diseases such as cancers and tumors, cardiovascular distress, high altitude diseases, pulmonary fibrosis, and pulmonary viral infections. Moreover, this component of hypoxia creates a molecular milieu which adds to robustness of the disease phenotype, limiting the efficacy of therapeutic interventions and at the same time triggering a cascade of pro-oxidant, pro-inflammatory mediators further exaggerating the disease. It has been noticed that the smart nanomaterials have revolutionized diagnostics, imaging, drug delivery, and therapeutic formulations with enhanced efficacy in disease management. This book showcases the versatility of hypoxia targeted smart nanoplatforms in disease management in diverse pathological settings, by various experts in the field. Overall, the themes in the book touch upon critical facets to address pathological hypoxia—nanomaterials enhancing oxygenation, hypoxia responsive nano-formulations which deliver the drug directly to the hypoxic site, limited toxicity and enhanced efficacy of smart nano-formulations to counter molecular consequences of hypoxia, theranostic combining hypoxia detection systems with drug delivery systems, etc. The book covers a wide range of concepts and new age advancements in the field of “intelligent” nanomaterials relevant to health care and is widely useful for the students, researchers, industry experts, and academia.

Spis treści

Bio-inspired nano systems interacting with the host environment: smart nano systems.- Recent progress in hypoxia-targeting: peptide-based nanomaterials.- New developments in nanotheranostics combined with intelligent bioresponsive systems.- Recent advancements in the field of stimuli-responsive nanopolymers for cancer treatment.- Novel Strategies to repress tumor hypoxia for the enhancement of cancer therapy.- Anopoxia: Antimonene-based nanoplatform for precision cancer therapy targeting cancer hypoxia.- Efficacy of diverse oxygen delivering nanoparticles in vitro and in animal models for treating hypoxia.- Anoproteomic: An approach for the identification of molecular targets associated with hypoxia.- Advances of nanomaterial with hypoxia inducible factor in periodontal inflammation.- ROS responsive silica nanoparticles for controlled and targeted drug delivery.- Tissue oxygenation and pH responsive fluorescent nano sensors in tumour diagnosis.- Hypoxia responsive nanomaterials for cerebral ischemia diagnosis.- Multifunctional hypoxia imaging nanoparticles.- Anaerobic bacteria mediated hypoxia-specific delivery of nanoparticles.- Reversible switch ON-OFF responsive nanoparticles in hypoxia management.

O autorze

Sonam Chawla is an Assistant Professor in Jaypee Institute of Information Technology, NOIDA since 2019. She has previously taught in Abdul Kalam Technical University, Uttar Pradesh, India; and also worked as Guest Lecturer in Lady Irwin College (DU), Delhi, India. Sonam completed her PhD from Defence Institute of Physiology and Allied Sciences (DIPAS), DRDO, Delhi as CSIR research fellow (CSIR JRF NET 2009). She is the recipient of the Vice-Chancellor's Medal in her graduation as well as post-graduation. Her area of work is hypoxia biology and ageing. She has guided 7 master’s students and 1 PhD student is working in the domain of anti-ageing phytomolecules. She has delivered several invited talks in national and international events and has >10 peer reviewed publications.

Sachidanand Singh is a Professor in the Department of Biotechnology, Sankalchand Patel University, Visnagar, Gujarat, India is B. Tech Biotechnology, M. Tech Bioinformatics and PhD in Bioinformatics. He has postdoctoral research experience from the College of Pharmacy, Ohio State University, USA. His specialization area includes Plant Biotechnology, metagenomics, Systems Biology and Drug design. He has more than 13 years of research and academic experience. He has served for a decade in the School of Biotechnology and Health Sciences, Karunya University, Coimbatore, Tamil Nadu, India. He also worked as consultant for college of pharmacy, Ohio State University as a Statistical Genetics during the year 2018. He has published more than 60 research articles in peer reviewed journals and completed one SERB, Govt of India funded project, two University research grant projects. He has received several awards in his area of research and for his teaching strategies. He has organized different conferences and workshops and received Govt. funds for the same. He has shared his area of expertise with different colleges and universities as invited speakers in different conferences and workshops. He has guided 36 B. Tech and 10 M. Tech projects. Presently 6 Ph. D students are enrolled under him and 2 Ph.D graduates are working in the field of herbal products, drug design and integrating with network biology. He has already edited around half-dozen of books for international publishing houses.

Azamal Husen served as Professor & Head, Department of Biology, University of Gondar, Ethiopia and is a Foreign Delegate at Wolaita Sodo University, Wolaita, Ethiopia. Earlier, he was a Visiting Faculty of the Forest Research Institute, and the Doon College of Agriculture and Forest at Dehra Dun, India. His research and teaching experience of 20 years involves studies of biogenic nanomaterial fabrication and application, plant responses to environmental stresses and nanomaterials at the physiological, biochemical and molecular levels, herbal medicine, and clonal propagation for improvement of tree species. He has conducted several research projects sponsored by various funding agencies, including the World Bank (FREEP), the National Agricultural Technology Project (NATP), the Indian Council of Agriculture Research (ICAR), the Indian Council of Forest Research Education (ICFRE); and the Japan Bank for International Cooperation (JBIC). He received four fellowships from India and a recognition award from the University of Gondar, Ethiopia, for excellent teaching, research, and community service. Husen has been on the Editorial board and the panel of reviewers of several reputed journals published by Elsevier, Frontiers Media, Taylor & Francis, Springer Nature, RSC, Oxford University Press, Sciendo, The Royal Society, CSIRO, PLOS, MDPI, John Wiley & Sons and UPM Journals. He is on the advisory board of Cambridge Scholars Publishing, UK. He is a Fellow of the Plantae group of the American Society of Plant Biologists, and a Member of the International Society of Root Research, Asian Council of Science Editors, and INPST. To his credit are over 200 publications; and he is Editor-in-Chief of the American Journal of Plant Physiology. He is also working as Series Editor of ‘Exploring Medicinal Plants’, published by Taylor & Francis Group, USA; ‘Plant Biology, Sustainability, and Climate Change’, published by Elsevier, USA; and ‘Smart Nanomaterials Technology’, published by Springer Nature Singapore Pte Ltd. Singapore.

Blurb

The book showcases the newest research on smart nanoplatforms responding to “hypoxia”; an omnipresent pathological feature of many modern-day diseases and its potential applications. The book demonstrates the versatility of hypoxia targeted smart nanoplatforms in disease management in diverse pathological settings presented in chapters contributed by various experts in the field. The themes in the book touch upon critical facets to address pathological hypoxia such as nanomaterials enhancing oxygenation, hypoxia responsive nanoformulations which deliver the drug directly to the hypoxic site, limited toxicity and enhanced efficacy of smart nanoformulations to counter molecular consequences of hypoxia, and theranostics combining hypoxia detection systems with drug delivery systems. This book disseminates the current implications of smart nanomaterials in disease management that can be exploited by scholars, researchers, and pharma industries to develop, manufacture, and commercialize hypoxia targeted diagnostics and therapeutics.