The present medical sciences identify pathological hypoxia as etiological as well as causative in a wide range of diseases such as cancers and tumors, cardiovascular distress, high altitude diseases, pulmonary fibrosis, and pulmonary viral infections. Moreover, this component of hypoxia creates a molecular milieu which adds to robustness of the disease phenotype, limiting the efficacy of therapeutic interventions and at the same time triggering a cascade of pro-oxidant, pro-inflammatory mediators further exaggerating the disease. It has been noticed that the smart nanomaterials have...