Comparative Toxicogenomics: Volume 2

ISBN-13: 9780444532749 / Angielski / Twarda / 2008 / 321 str.

Christer Hogstrand

Opis

Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information.

This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully applied to different research areas. This book transects biology from bacteria to human, from ecologically relevant sentinel organisms to well-characterized model species, and represents the full toxicogenomics arena from exploratory "blue sky" science to the prospects for incorporation into regulatory frameworks.

* Reviews some of the first really fruitful studies made in this area
* Covers different organisms ranging from humans to model species and environmental sentinels
* Provides a broad view of the area, increasing its attractiveness to researchers working in a variety of specialties

Spis treści

Daphnia Toxicogenomics
Joseph R. Shaw, Dartmouth College
Human Toxicogenomics
Professor Joseph Lunec and Dr. Eugene Halligan, King's College London
Metabolomics and Toxicogenomics
Jake Bundy and Jeremy Nicholson, Imperial College
Model Organisms of Environmental Toxicogenomics (Ecotoxicological model species - Daphnia, fathead minnow and zebrafish)
Chris Vulpe, University of California, Berkely
Non-model organism Toxicogenomics or Earthworm Toxicogenomics
David Spurgeon, CEH Monks Wood
Application of Toxicogenomics for study of endocrine disruption in fish
Charles Tyler, Exeter
Microbial Toxicogenomics
Jason Snape, Astra-Zeneca Brixham Enviornmental Laboratories
Comparative Toxicogenomics
Jonathan Freedman, NIEHS