This volume provides a novel insight to the evolutionary and comparative aspects of nitric oxide- nitric oxide synthase system as a central regulator of invertebrate and vertebrate homeostasis. By critically selecting and summarizing the ever-increasing number of original studies, these presentations review a variety of important signalling and modulatory roles played by nitric oxide at molecular, cell, organ and organ system levels. It addresses not only specialists and graduate students in the field, but also all biologists concerned with how this unique, gaseous, pleiotropic molecule has...

Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information.

This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a...