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Novel Approaches to Selective Treatments of Human Solid Tumors: Laboratory and Clinical Correlation
ISBN: 9781461360605 / Angielski / Miękka / 319 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The therapeutic efficacy of FUra has been attributed to its incorporation into cellular RNA and, to its inhibition of thymidylate synthase, leading to potent inhibition of DNA synthesis and DNA damage. Studies of cell lines in vitro and model systems in vivo have demonstrated that although mechanisms of sensitivity and resistance to FUra are multifactorial, in the presence of citrovorum factor (LV, CF, 5-formyltetrahydrofolate) the site of action of FUr a becomes predominantly the pronounced and prolonged inhibition of thymidylate synthase. This action is the result of stabilization of the...
The therapeutic efficacy of FUra has been attributed to its incorporation into cellular RNA and, to its inhibition of thymidylate synthase, leading to...
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Modern Methods in Analytical Morphology
ISBN: 9781461360797 / Angielski / Miękka / 445 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. While advances in modem medicine largely parallel our understanding of morphology, discoveries in morphology are propelled by developments of new tools and means to visualize and measure tissue elements. The invention of dissecting, light, fluorescence and electron microscopes together with advances in labeling and staining techniques are among the stepping stones of morphological progress. Today, we are in an exciting new era when classical morphology is being combined with developments from other disciplines. The combination of morphology and immunology resulted in immunocytochemistry;...
While advances in modem medicine largely parallel our understanding of morphology, discoveries in morphology are propelled by developments of new tool...
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Endoplasmic Reticulum
ISBN: 9781461362630 / Angielski / Miękka / 358 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. In step with the surge of interest in the endoplasmic reticulum, the current volume takes an integrated look at this functionally diverse organelle. Coverage includes protein translocation and export, lipid metabolism, antigen presentation, and many other subjects, gleaned from such diverse fields as cell biology, enzymology and membrane biochemistry, immunology, and signal transduction.
In step with the surge of interest in the endoplasmic reticulum, the current volume takes an integrated look at this functionally diverse organelle. C...
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Modern Trends in Biothermokinetics
ISBN: 9781461362883 / Angielski / Miękka / 498 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book includes articles relating to presentations given in a variety of forms (lectures, posters, contributions to round tables, software presentations) at the 5th International Biothermokinetics Meeting held in Bordeaux-Bombannes, September 23-26, 1992. The fact that not just lectures were considered for these proceedings reflects the aims of BTK meetings to instigate discussion, promote scientific cooperation and confront as many different ideas as possible with each other (at best heretical ones). BTK conferences have expanded more and more; 130 participants came to the 1992 meeting...
This book includes articles relating to presentations given in a variety of forms (lectures, posters, contributions to round tables, software presenta...
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Mechanisms of Platelet Activation and Control
ISBN: 9781461363040 / Angielski / Miękka / 272 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Recent years have seen tremendous advances in our understanding of the molecular mechanism of platelet activation. All aspects of signal transduction in platelets from the identification of surface receptors, G proteins, phospholipases, protein kinases and phosphatases, intracellular receptors for inositol phosphates, the Ca2+ regulatory machinery, cytoskeletal constituents to the control mechanism employing cyclic nucleotides has seen an explosion of information regarding their importance and for each constituent in the family of molecules to which they belong. This information has been of...
Recent years have seen tremendous advances in our understanding of the molecular mechanism of platelet activation. All aspects of signal transduction ...
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Progress in Neutron Capture Therapy for Cancer
ISBN: 9781461364948 / Angielski / Miękka / 668 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Despite the many advances made in the diagnosis and therapy of cancer, the mortality rate is still about half that of the incidence rate. However, the odds are not evenly distributed. Prognosis for some cancers is good, but for others, few patients will survive 12 months. This latter group of cancers is characterised by a proclivity to disseminate malignant cells in the host organ. The degree of surgery possible may be limited by the critical nature of the organ, and chemotherapy and radiotherapy are of palliative value only. In some cases systemic metastases occur, but in other cases,...
Despite the many advances made in the diagnosis and therapy of cancer, the mortality rate is still about half that of the incidence rate. However, the...
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Transport and Receptor Proteins of Plant Membranes: Molecular Structure and Function
ISBN: 9781461365235 / Angielski / Miękka / 213 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This book presents the contributions of the main speakers to the 12th Long Ashton InternationalSymposium, heldat theUniversityofBristolfrom 17thto20thSeptember 1991. Manyofthe 160delegates who attended presented posters, the abstractsofwhich have been published separately and reflected thevigour, excitementand originalityofthepresentations. The identity and molecular structure of solute of membrane proteins are of interest in of themselves but may be seen as only a step towards broader questions about the regulation their activity and their integration into the lifeofcells and organisms. This...
This book presents the contributions of the main speakers to the 12th Long Ashton InternationalSymposium, heldat theUniversityofBristolfrom 17thto20th...
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Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells
ISBN: 9781461366911 / Angielski / Miękka / 406 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The ability of neoplastic cells to survive exposure to various chemotherapeutic drugs represents the main obstacle to successful cancer chemotherapy. This book deals with a particular type of resistance in tumor cells that represents a single but especially important aspect of the multifaceted problem of cancer drug resistance. This type of resistance, known as multidrug or pleiotropic drug resistance, is characterized by cross-resistance of cells to several different classes of cytotoxic drugs, including some of the most commonly used anticancer agents. Over the last several years, there has...
The ability of neoplastic cells to survive exposure to various chemotherapeutic drugs represents the main obstacle to successful cancer chemotherapy. ...
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Genomic Instability and Immortality in Cancer
ISBN: 9781461374480 / Angielski / Miękka / 251 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The eighth Annual Pezcoller Symposium, entitled Genomic Instability and Immor- tality in Cancer, was held in Trento, Italy, June 17-19, 1996 and was focused on the clari- fication of the mechanisms of genetic instability, a characteristic of neoplastic cells which also determines tumor progression, and immortality consequent to the lack of susceptibil- ity to mechanisms of maturations, senescence and/or apoptosis. With presentations at the cutting edge of progress and stimulating discussions, this symposium addressed issues related to mutational lability, changes in DNA repair capa- bilities,...
The eighth Annual Pezcoller Symposium, entitled Genomic Instability and Immor- tality in Cancer, was held in Trento, Italy, June 17-19, 1996 and was f...
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Glycoimmunology 2
ISBN: 9781461374572 / Angielski / Miękka / 274 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The Jenner International Glycoimmunology Meetings have charted the rapid devel- opment of glycobiology within the field of inflammation. In less than a decade, the science has grown from basically being involved in carbohydrate analysis to the understanding of how sugars are associated with inflammation and how they have potential as anti- inflammatory therapeutics. The 4th Jenner International Glycoimmunology Meeting was re- cently held in Loutraki, Greece, and set the scene for what promises to be an exciting future for the speciality. Discussion reflected the rapid advances glycobiology is...
The Jenner International Glycoimmunology Meetings have charted the rapid devel- opment of glycobiology within the field of inflammation. In less than ...
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Chemistry and Biology of Serpins
ISBN: 9781461374619 / Angielski / Miękka / 358 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Serpins (serine protease inhibitors) are a superfamily of proteins whose physiologi- cal action is primarily targeted to inhibiting serine proteases. There are instances where serpins are not inhibitors (and can carry steroid hormones for instance), yet key structural and functional elements found in all serpins are maintained in these 'non-inhibitor' ser- pins. Many serpins have well-described biological properties which influence pathophysi- ological events, including: antithrombin (historically called antithrombin III), ai-protease inhibitor (historically called ai-antitrypsin), and...
Serpins (serine protease inhibitors) are a superfamily of proteins whose physiologi- cal action is primarily targeted to inhibiting serine proteases. ...
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Cancer Genes: Functional Aspects
ISBN: 9781461377047 / Angielski / Miękka / 286 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The seventh Annual Pezcoller Symposium entitled, Cancer Genes: Functional As- pects, was held in Trento, Italy, June 14-16, 1995 and was focused on oncogenes func- tion, tumor suppressor gene function, transcription regulation, cell cycle progression regulation and apoptosis, and the clinical implications of oncogene function and regula- tion for prevention and therapy of cancer. With presentations at the cutting edge of pro- gress and stimulating discussions, this Symposium addressed issues related to the mechanisms of control of cell growth and death by certain genes such as c-myc, src,...
The seventh Annual Pezcoller Symposium entitled, Cancer Genes: Functional As- pects, was held in Trento, Italy, June 14-16, 1995 and was focused on on...
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Theoretical and Computational Methods in Genome Research
ISBN: 9781461377085 / Angielski / Miękka / 330 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The application ofcomputational methods to solve scientific and practical problems in genome research created a new interdisciplinary area that transcends boundaries tradi- tionally separating genetics, biology, mathematics, physics, and computer science. Com- puters have, of course, been intensively used in the field of life sciences for many years, even before genome research started, to store and analyze DNA or protein sequences; to explore and model the three-dimensional structure, the dynamics, and the function of biopolymers; to compute genetic linkage or evolutionary processes; and...
The application ofcomputational methods to solve scientific and practical problems in genome research created a new interdisciplinary area that transc...
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Alpha and Gamma Motor Systems
ISBN: 9781461357933 / Angielski / Miękka / 656 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The Sherrington School of Physiology at St. Thomas' Hospital provided a natural venue for four days of enthusiastic debate on Sherrington's Final Common Path -the alpha motoneurone and related matters; Sherrington himself held a lecturership at St. Thomas' just over a century ago. The occasion was a happy one. Most participants already knew each other, the topics were familiar, the discussion was vigorous and critical but without personal rancor. The program had set out to encourage debate with 'critiques' both of the oral papers and the posters; their inclusion in the present volume helps to...
The Sherrington School of Physiology at St. Thomas' Hospital provided a natural venue for four days of enthusiastic debate on Sherrington's Final Comm...
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Methods in DNA Amplification
ISBN: 9781461360780 / Angielski / Miękka / 251 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. The polymerase chain reaction (PCR) - an in Vitro techniques for producing large amounts of a specific DNA fragment - has rapidly become established as one of the most important, impressive and fascinating methods of molecular biology as well as clinical diagnostics. In the seven years since'the technique was published, it has had a major impact on medical research. However, as there are still problems in instruments, standardized protocols for diagnostic applications and unsolved difficulties to avoid cross-contaminations on the one hand and on the other hand the even present question of how...
The polymerase chain reaction (PCR) - an in Vitro techniques for producing large amounts of a specific DNA fragment - has rapidly become established a...
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Cell Culture Engineering IV: Improvements of Human Health
ISBN: 9789401041140 / Angielski / Miękka / 376 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Cell Culture Engineering IV, Improvements of Human Health covers the latest approaches to improving the cell host through improved understanding of the molecular biology, the development of novel vaccines, approaches to bioreactor design and operation, monitoring techniques in process control and quality related topics. The work was carefully put together as one result of the Cell Culture Engineering IV Meeting held in San Diego, U.S.A. in 1994, however, the book may not be perceived as a proceedings volume - the criteria of the book series apply.
For cell biologists,... Cell Culture Engineering IV, Improvements of Human Health covers the latest approaches to improving the cell host through improved understand...
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Rotifera VIII: A Comparative Approach: Proceedings of the Viiith International Rotifer Symposium, Held in Collegeville, Minn., U.S.A., 22-27 June 1997
ISBN: 9789401060097 / Angielski / Miękka / 498 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Rotifera VIII: A Comparative Approach is a record of the proceedings of the VIIIth International Rotifer Symposium which was held in Collegeville, Minnesota, USA, on June 22-27, 1997. It contains review papers and reports of recent research findings along with the presentation of new methods in rotifer biology. The publications contained in this volume reflect the wide diversity of approaches, methods of analysis and conclusions that characterize research on the Rotifera. Some of the topics addressed are: rotifer distribution, responses to biotic and abiotic factors, genetic profile...
Rotifera VIII: A Comparative Approach is a record of the proceedings of the VIIIth International Rotifer Symposium which was held in Collegev...
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Insect Populations in Theory and in Practice: 19th Symposium of the Royal Entomological Society 10-11 September 1997 at the University of Newcastle
ISBN: 9789401060608 / Angielski / Miękka / 486 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. Insects are by far the largest group of animals on Earth, with over a million described species, and they occupy a wide range of ecological niches - they may be herbivores, predators, parasites or decomposers. Some are of particular economic importance as pests of agriculture and forestry, as vectors of animal and human disease, or as species of interest to wildlife conservation. Thus an understanding of the processes determining their numbers is of considerable practical value.
Entomologists have played a leading role in developing a theoretical basis to Population Ecology, but we... Insects are by far the largest group of animals on Earth, with over a million described species, and they occupy a wide range of ecological niches - t...
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Purine and Pyrimidine Metabolism in Man VIII
ISBN: 9781461361053 / Angielski / Miękka / 836 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. These volumes record the presentations made at the VIII International Symposium on Purine and Pyrimidine Metabolism in Manheld at Indiana University, Bloomington, USA from May 22- May 27, 1994. This was a continuation of meetings held every three years with the idea of bringing clinicians and basic scientists together, which we hope results in cross-fertilization of ideas. Some of the papers presented in this volume represent oral contributions and others are from posters, but we emphasize that both are considered of equal merit. As is obvious from a perusal of the titles of the papers there...
These volumes record the presentations made at the VIII International Symposium on Purine and Pyrimidine Metabolism in Manheld at Indiana University, ...
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Mechanism of Myofilament Sliding in Muscle Contraction
ISBN: 9781461362456 / Angielski / Miękka / 866 str. Termin realizacji zamówienia: ok. 5-8 dni roboczych. This volume presents the entire proceedings of the symposium organized by one of us (H. S. ) on November 11 to 15, 1991 at Hakone, Japan, under the title of "Mechanism of Myofllament Sliding in Muscle Contraction. " Among various kinds of energy transduction mechanisms in biological systems, the mechanism of muscle contraction has been studied most intensively and extensively over many years. Since the monumental discovery by the two Huxleys and coworkers that muscle contraction results from relative sliding between the thick and thin myofilaments, attention of muscle investigators has been...
This volume presents the entire proceedings of the symposium organized by one of us (H. S. ) on November 11 to 15, 1991 at Hakone, Japan, under the ti...
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